Results 41 to 50 of about 240,947 (277)

11. Objectively Funny Jokes: Comedy’s El Dorado or a Simple MacGuffin? [PDF]

open access: yes, 2020
Could there ever be an objectively funny joke or bit of humor? With the popularity of certain forms of humor, with the appearance of puns as consistent stages in the development of humor in children, this seems a reasonable query.
Cundall, Michael
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Sexism and Jokes: a Case Study [PDF]

open access: yes, 2017
The aim of this paper is to analyse how the interviewees reacted to sexist jokes and to compare it to how they reacted to sexist statements, in order to find out if there is a discrepancy between what people perceive as humour and a serious statement ...
Sambati, Giulia
core  

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

open access: yesFEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi   +6 more
wiley   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

open access: yesFEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

open access: yesFEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng   +2 more
wiley   +1 more source

Epistemic Vigilance, Cautious Optimism and Sophisticated Understanding [PDF]

open access: yes, 2012
Humans have developed a critical alertness to the believability and reliability of communication: epistemic vigilance (Sperber et al. 2010). It is responsible for trusting interlocutors and believing interpretations.
Padilla Cruz Manuel
core   +2 more sources

Joke construction and joke structure

open access: yes, 2020
This paper deals with the thorny but fascinating process of (re)constructing jokes, the dynamic process of retelling, which produces a joke structure that is often different from “canonical”. In order to study this, I have exposed a small group of native speakers of Polish and a few native speakers English of both genders to a doctor joke in the ...
openaire   +2 more sources

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

open access: yesAdvanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana   +2 more
wiley   +1 more source

The Apple-Sauce Chronicles [PDF]

open access: yes, 1984
In his excellent book on formula jokes, Jokes, Paul Dickson comments that What\u27s the Difference? jokes, a blend of conundrum and pun, can be found in very old joke books. Some of the examples below are homonymic in nature; others reverse the first and
Phillips, Louis
core   +2 more sources

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