Results 91 to 100 of about 1,904,641 (304)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Stability Analysis of the Rotor-Journal Bearing System Considering Shear and Gaseous Cavitation

Lubricants
Part of the gas phase within the bearing emanates from the gaseous lubricating medium generated by the phase transition of the liquid lubricant under low pressure, while the remaining portion originates from the expansion of gases, such as air, present ...
Lin Sun, Jianchao Shi, Tao Jiang, Zhen Li, Quntao Xie, Zhaozeng Liu, Weiwei Xu   +6 more
doaj   +1 more source

A new gaseous cavitation model in a tilting-pad journal bearing. [PDF]

Sci Prog, 2021
Ding A, Ren X, Li X, Gu C.
europepmc   +1 more source

Shallow grooves in journal improve air bearing performance [PDF]

, 1968
Bearing designs, which shape the surface to create artificial fluid-film wedges in the absence of any applied radial load, generate radial restoring forces to keep journals from whirling.
Anderson, W. J., Cunningham, R. E., Fleming, D. P.   +2 more
core   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that preces the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Nonlinear Dynamic Response of Compliant Journal Bearings

MATEC Web of Conferences, 2012
This paper investigates the dynamic response of the compliant tilting pad journal bearings subjected to synchronous excitation. Bearing compliance is affected by the properties of pad liner and pad support geometry. Different unbalance eccentricities are
Glavatskih S., Cha M.
doaj   +1 more source

Experimental and Numerical Investigation of Static and Dynamic Characteristics of Bio-Oils and SAE40 in Fluid Film Journal Bearing. [PDF]

Materials (Basel), 2022
Sadiq MI, Ghopa WAW, Nuawi MZ, Rasani MR, Mohd Sabri MA.   +4 more
europepmc   +1 more source

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

Advanced Science, EarlyView.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng, Shuang Cai, Chen Guo, Shaker Khan, Lefan Liu, Qiong Tian, Zhiyuan Ma, Jian Zhang, Lingyu Zhao   +8 more
wiley   +1 more source

Prediction on Flow and Thermal Characteristics of Ultrathin Lubricant Film of Hydrodynamic Journal Bearing. [PDF]

Micromachines (Basel), 2021
Jiang Y, Liang B, Huang Z, Chen Z, Xu B.
europepmc   +1 more source

Nanozymes for Liver Disease Therapy: Advances in Catalytic Activity, Targeting Strategies, and Clinical Translation

Advanced Science, EarlyView.
Nanozymes, as enzyme‐mimicking nanomaterials, exhibit unique catalytic properties for the treatment of liver diseases. By regulating redox homeostasis, modulating immune responses, and enabling targeted delivery, nanozymes overcome the limitations of natural enzymes.
Xiandi Meng, Ge Zhu, Siyu Sun, Wenbo Yao, Yuning Zhang, Yong‐Guang Yang, Tianmeng Sun   +6 more
wiley   +1 more source