Results 121 to 130 of about 250,731 (245)
T Cell O‐GlcNAcylation Increases in Patients With Allergic Rhinitis After the Natural Pollen Season
Clinical &Experimental Allergy, EarlyView.
Eduardo I. Cardenas +7 more
wiley +1 more source
Acta Crystallographica Section D, Volume 82, Issue 5, Page 550-570, May 2026.This study investigates the mycobacterial membrane protein MmpL3, a key target for new antituberculosis drugs, by combining high‐resolution crystallography and computational simulations. It reveals how the inhibitor UPAR‐1109 binds to MmpL3, providing detailed insights into the function and flexibility of the protein and supporting the rational design ...
Satoshi Murakami +9 more
wiley +1 more source
A cryo‐EM processing pipeline for microtubules using CryoSPARC
Acta Crystallographica Section D, Volume 82, Issue 5, Page 411-420, May 2026.Cryo‐EM reconstructions of microtubules are currently technically challenging and time‐consuming for average users. A cryo‐EM processing pipeline for microtubules using CryoSPARC has been developed that overcomes many of these current issues.Microtubules are cytoskeletal filaments that are typically characterized by a discontinuous helical lattice of α/
Daniel Zhang +7 more
wiley +1 more source
Journal of Cannabis ResearchBackground Minor cannabinoids, including cannabigerol (CBG), cannabinol (CBN), and cannabichromene (CBC), are gaining scientific attention for their distinct therapeutic potential beyond THC and CBD.
Hanane Abbou +2 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 9, Page 1901-1919, May 2026.Abstract Background and Purpose Extensive evidence indicates that lipid accumulation causes renal tubular injury, which further contributes to diabetic nephropathy (DN) progression. Short‐chain fatty acids (SCFAs) play an important role in the maintenance of cellular metabolic health.
Jiayin Tao +12 more
wiley +1 more source
Frontiers in OncologyBackgroundLiver cancer is highly prevalent worldwide. However, current medical treatments remain insufficient. Although herbal medicine has a long history and extensive expertise in treating liver cancer, the literature in this field has not been ...
Yusha Shi +6 more
doaj +1 more source
Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1
British Journal of Pharmacology, Volume 183, Issue 9, Page 1845-1859, May 2026.Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim +10 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 10, Page 2518-2532, May 2026.Background and Purpose Dopamine receptor agonists, particularly targeting the dopamine D2L receptor (D2LR), have been used to treat Parkinson's disease (PD). However, valvular heart disease and somnolence, mainly caused by activating the serotonin 5‐HT2B receptor (5‐HT2BR) and dopamine D3 receptor (D3R), respectively, currently challenge their clinical
Takayuki Suzuki +4 more
wiley +1 more source
World Journal of Traditional Chinese MedicineObjective: We undertook a knowledge map-based visual analysis of the literature concerning the use of Traditional Chinese Medicine (TCM) for treating lung cancer.
Fang-Fang Qin +4 more
doaj +1 more source
In vitro and in vivo evaluation of cephalosporins for the treatment of Lyme disease. [PDF]
, 2018 BackgroundLyme disease accounts for >90% of all vector-borne disease cases in the United States and affect ~300,000 persons annually in North America.
Ambati, Aditya +9 more
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