Results 71 to 80 of about 185,227,745 (225)

Molecular Docking in Drug Discovery: Techniques, Applications, and Advancements [PDF]

Objective: The primary objective of this study is to conduct a comprehensive review of the significance of molecular docking in the field of drug discovery.
Ihosvany, Camps, Cinthia, Aguiar
core   +1 more source

Docking-guided molecular mechanics and estimation of ligand binding energies of PTB-related drugs with CNN1 isoform 2.

, 2023
Docking-guided molecular mechanics and estimation of ligand binding energies of PTB-related drugs with CNN1 isoform 2.
Waqasuddin Khan (453320), M. Kamran Azim (683478), Muhammad Imran Nisar (10226212), Fyezah Jehan (571965), Muhammad Bilal Azmi (14519913)   +4 more
core   +1 more source

Research Trends and Mechanistic Insights Into Natural Medicines for Alzheimer's Disease: A Bibliometric Analysis and Narrative Review

Phytotherapy Research, EarlyView.
Research landscape and mechanistic insights into natural medicines for Alzheimer's disease. ABSTRACT Natural medicines have been widely investigated for Alzheimer's disease (AD), but the development of this field and the relationship between bibliometric themes and experimental evidence remain insufficiently characterized.
Maoning Wang, Xiaolian Zhang, Huaxian Yang, Jianhe Zhao, Wentao Wei, Qian Zhao, Wenjia Wang, Yunhui Hu, Jiansong Fang   +8 more
wiley   +1 more source

Notoginsenoside‐Fa mitigates vascular endothelial permeability via targeting SUGT1 to stabilize NLRP3 in a resting state

British Journal of Pharmacology, EarlyView.
Background and Purpose Notoginsenoside‐Fa (Noto‐Fa) is an emerging active compound derived from notoginseng with promise in treating cardiovascular diseases. The development of cardiovascular diseases is intricately linked to the damage of vascular endothelium and it is widely acknowledged that numerous chronic inflammation pathways, especially the ...
Xiao‐Ying Yu, Da‐Hao Mai, Xing‐Ming Zhong, Li‐Ting Huang, Lan‐Ting Fu, He‐Cai Wang, Ke Wang, Hai‐Yan Li, Qiu‐He Chen, Yang Chen   +9 more
wiley   +1 more source

Understanding and addressing the global impact: A systematic review and cross-sectional bibliometric analysis of Langya henipavirus and pre-existing severe henipaviruses

Journal of Infection and Public Health
In 2022, Langya henipavirus was identified in patients with fever in eastern China. This study provides an overview of the scientific landscape, highlights research focus areas, and outlines potential future investigations.
Jian-Di Li, Yu-Qing Liu, Rong-Quan He, Zhi-Guang Huang, Wan-Ying Huang, Hong Huang, Zhi-Hong Liu, Gang Chen   +7 more
doaj   +1 more source

Selective excitatory effects of γ‐glutamyl‐glycine, a glutathione metabolite, on GluN1 NMDA and mGlu5 receptors impacting synaptic plasticity

British Journal of Pharmacology, EarlyView.
Background and Purpose Gamma‐glutamyl dipeptides are essentially produced after glutathione (GSH) degradation. While several γ‐glutamyl dipeptides have been detected in different organs and body fluids, their biological activity remains elusive. This is the case for γ‐Glutamyl‐Glycine (γ‐Glu‐Gly) which has been found in different brain areas.
Sandro Andreu, Victoria Gizzi, Ugo Pasco, Fatiha Sebih, Yattou Zitouni, Pablo Jimenez, Valérie Rolland, Alain Chavanieu, Sébastien Estaran, Matthieu Rousset, Thierry Cens, Guillaume Cazals, Pierre Charnet, Janique Guiramand, Catherine Cohen‐Solal, Claudine Ménard, Marie‐Céleste de Jésus Ferreira, Nathalie Chevallier, Sonia Cantel, Michel Vignes, Julien Roussel   +20 more
wiley   +1 more source

Exploring the potent antimalarial properties of Drimys beccariana Gibbs through molecular docking analysis utilizing advanced structure-based drug design techniques

Journal of Advanced Pharmaceutical Technology & Research
Original Article Exploring the potent antimalarial properties of Drimys beccariana Gibbs through molecular docking analysis utilizing advanced structure-based drug design techniques Hermanto, Faizal; Ratih, Hestiary1; Alatas, Fikri1; Sutarna, Titta ...
Faizal Hermanto, Hestiary Ratih, Fikri Alatas, Titta Hartyana Sutarna   +3 more
doaj   +1 more source

Molecular docking, molecular modeling, and molecular dynamics studies of azaisoflavone as dual COX-2 inhibitors and TP receptor antagonists

, 2018
Designed multi-target ligand (DML) is an emerging strategy for the development of new drugs and involves the engagement of multiple targets with the same moiety. In the context of NSAIDs it has been suggested that targeting the thromboxane prostanoid (TP)
Mahapatra, Amarjyoti Das, Datta, Bhaskar, Bhaskar Datta, Yadav, Jitender K., Hadianawala, Murtuza, Murtuza Hadianawala, Amarjyoti Das Mahapatra, Jitender K. Yadav   +7 more
core   +1 more source

Repurposed catechol‐O‐methyltransferase inhibitors tolcapone and entacapone preferentially suppress aggregation and seeding of P301 mutant tau in human neuronal models

British Journal of Pharmacology, EarlyView.
Background and purpose Pathogenic aggregation and propagation of seed‐competent TAU assemblies drive tauopathies. MAPT P301 mutations accelerate aggregation and enhance seed competence, yet pharmacological strategies selectively targeting these pathogenic species remain limited.
Ihor Kozlov, Yu‐Sheng Hung, Sudeep Roy, Alladi Charanraj Goud, Roman Kouřil, Yu‐Hui Wong, Viswanath Das   +6 more
wiley   +1 more source

Docking and QSAR Studies of Camptothecin Derivatives as Inhibitor of DNA Topoisomerase-I [PDF]

, 2011
Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme Topoisomerase-I (Topo-I) and has shown remarkable anticancer activity in preliminary clinical trials. The major limitation is its low solubility and high adverse reaction.
Feroz Khan, Feroz Khan, Santosh Srivastava, Dharmendra K. Yadav, Santosh K. Srivastava, Dharmendra Yadav   +5 more
core   +1 more source