Results 81 to 90 of about 250,731 (245)

The Versatile Molecular Complex Component LC8 Promotes Several Distinct Steps of Flagellar Assembly [PDF]

, 2012
LC8 is present in various molecular complexes. However, its role in these complexes remains unclear. We discovered that although LC8 is a subunit of the radial spoke (RS) complex in Chlamydomonas flagella, it was undetectable in the RS precursor that is ...
Anjali Gupta, Barbar, Bergen, Bloch, Dennis R. Diener, DiBella, Diener, Diener, Dymek, Dymek, Espindola, Fejtova, Gaillard, Hall, Harris, Heuser, Huang, Jaffrey, Jivan, Joel L. Rosenbaum, Johnson, Kamiya, Kindle, King, LeDizet, Liang, Lightcap, Lin, Lo, Lo, Luo, Naisbitt, Navarro-Lérida, Nicastro, Patel-King, Pazour, Pazour, Pfister, Pigino, Pinfen Yang, Piperno, Piperno, Porter, Priyanka Sivadas, Puthalakath, Qin, Rodríguez-Crespo, Rompolas, Sakato, Segal, Stelter, Summers, Tan, Warner, Wei, Williams, Wirschell, Yang, Yang, Yang, Yang, Yang   +61 more
core   +2 more sources

Crystal structure of Plasmodium vivax macrophage migration inhibitory factor

Acta Crystallographica Section F, EarlyView.
The production, crystallization and 1.8 Å resolution crystal structure of macrophage migratory inhibitory factor from P. vivax are reported.Plasmodium vivax is a major cause of malaria globally and has recently been transmitted locally in the USA. P. vivax produces homologs of host proteins, including cytokines such as macrophage migration inhibitory ...
Aryana Nair, Matthew Lin, Arav Srivastava, Lijun Liu, Anne Cooper, Kevin Battaile, Elizabeth Harmon, Peter J. Myler, Bart L. Staker, Scott Lovell, Graham Chakafana, Oluwatoyin A. Asojo   +11 more
wiley   +1 more source

(E)-3-Heteroarylidenechroman-4-ones as potent and selective monoamine oxidase-B inhibitors [PDF]

, 2016
A series of (E)-3-heteroarylidenechroman-4-ones (1a-r) was designed, synthesized and investigated in vitro for their ability to inhibit the enzymatic activity of both human monoamine oxidase (hMAO) isoforms, hMAO-A and hMAO-B.
Alcaro, Stefano, BIAVA, Mariangela, DESIDERI, Nicoletta, FIORAVANTI, Rossella, Ortuso, Francesco, PROIETTI MONACO, LUCA, Yáñez, Matilde   +6 more
core   +1 more source

Second‐generation prokineticin PKR1 receptor agonists: Advancing cardioprotection against chemotherapy‐induced toxicity

British Journal of Pharmacology, EarlyView.
IS39, a novel non‐peptide PKR1 agonist, confers cardioprotection against doxorubicin‐induced toxicity. IS39 activates PKR1‐mediated pro‐survival signalling in cardiomyocytes, reducing reactive oxygen species (ROS), DNA damage and fibrosis markers. In vivo, IS39 preserves cardiac geometry and function in mice exposed to chronic doxorubicin challenge ...
Anais Audebrand, Simone Brogi, Mustafa Tezeren, Andrea Tafi, Omer H. Ocak, Hasan Koyuncu, Igor Tetko, Laurent Désaubry, Canan G. Nebigil   +8 more
wiley   +1 more source

Exploring Tenebrio molitor as a source of low‐molecular‐weight antimicrobial peptides using a n in silico approach: correlation of molecular features and molecular docking

The Journal of the Science of Food and Agriculture
BACKGROUND Yellow mealworm (Tenebrio molitor) larvae are increasingly recognized as a potential source of bioactive peptides due to their high protein content. Antimicrobial peptides from sustainable sources are a research topic of interest.
Teresa Gonzalez-de la Rosa, Elvira Marquez-Paradas, Maria J. Leon, Sergio Montserrat‐de la Paz, F. Rivero‐Pino   +4 more
semanticscholar   +1 more source

Notoginsenoside‐Fa mitigates vascular endothelial permeability via targeting SUGT1 to stabilize NLRP3 in a resting state

British Journal of Pharmacology, EarlyView.
Background and Purpose Notoginsenoside‐Fa (Noto‐Fa) is an emerging active compound derived from notoginseng with promise in treating cardiovascular diseases. The development of cardiovascular diseases is intricately linked to the damage of vascular endothelium and it is widely acknowledged that numerous chronic inflammation pathways, especially the ...
Xiao‐Ying Yu, Da‐Hao Mai, Xing‐Ming Zhong, Li‐Ting Huang, Lan‐Ting Fu, He‐Cai Wang, Ke Wang, Hai‐Yan Li, Qiu‐He Chen, Yang Chen   +9 more
wiley   +1 more source

Estudios de acoplamiento molecular de nuevos análogos de quinolonas a la ADN girasa de Escherichia coli [PDF]

, 2018
Indexación: Scopus.Chemicals and CAS Registry Numbers: amino acid, 65072-01-7; ciprofloxacin, 85721-33-1; DNA topoisomerase (ATP hydrolysing); gatifloxacin, 112811-59-3, 180200-66-2; levofloxacin, 100986-85-4, 138199-71-0; lomefloxacin, 98079-51-7 ...
Davila, C., Llach, L., Ramirez-Tagle, R., Salgado-Moran, G.   +3 more
core  

Predicted Structures and Dynamics for Agonists and Antagonists Bound to Serotonin 5-HT2B and 5-HT2C Receptors [PDF]

, 2011
Subtype 2 serotonin (5-hydroxytryptamine, 5-HT) receptors are major drug targets for schizophrenia, feeding disorders, perception, depression, migraines, hypertension, anxiety, hallucinogens, and gastrointestinal dysfunctions.' We report here ...
Abrol, Ravinder, Goddard, William A., III, Heo, Jiyoung, Kim, Soo-Kyung, Li, Youyong   +4 more
core   +2 more sources

Alchemical Grid Dock (AlGDock): Binding Free Energy Calculations between Flexible Ligands and Rigid Receptors

, 2019
Alchemical Grid Dock (AlGDock) is open-source software designed to compute the binding potential of mean force (BPMF) - the binding free energy between a flexible ligand and a rigid receptor - for a small organic ligand and a biological macromolecule ...
Minh, David D. L
core   +1 more source

Therapeutic potential of small molecules that block receptor‐induced Kv7/M‐current suppression in neuroprotection, seizures, and pain

British Journal of Pharmacology, EarlyView.
Receptor‐induced Kv7/M‐current suppression increases neuronal activity and contributes to pathology of several conditions. A new class of Kv7 modulators identified in this study attenuates M‐current suppression and shows therapeutic effects. Abstract Background and Purpose Neuronal Kv7 channels generate low voltage–gated potassium currents known as the
Young Woo Kim, Pavan Kumar Behara, Lamees Alhassen, Cindy Wong, Olivier Civelli, Naoto Hoshi   +5 more
wiley   +1 more source