Results 81 to 90 of about 185,227,745 (225)

Positive modulation of glucagon‐like peptide 1 (GLP‐1) receptor by endogenous haemorphins with implications in glucose metabolism and diabetes

British Journal of Pharmacology, EarlyView.
Haemorphins act on GLP‐1 receptor (GLP‐1R) activity and signalling in a positive allosteric manner. This leads to potentiated GLP‐1‐mediated activity and signalling, as well as insulin synthesis, which may have implications for glucose metabolism and, thereby, diabetes and obesity. (The graph was created in BioRender.com).
Farheen Badrealam Khan, Rwdah Mohamed Alameri, Yasir S. Raouf, Damien Maurel, Naiem Ahmad Wani, Anatoliy Shmygol, Irfa Anwar, Heng B. See, Elizabeth K. M. Johnstone, Elodie Dupuis, Eric Trinquet, Kevin D. G. Pfleger, Emilia Oueis, Mohammed Akli Ayoub   +13 more
wiley   +1 more source

Synergistic phytochemicals in multi-target drug discovery for complex diseases: A narrative review

Phytomedicine Plus
Background/problem statement: Single-target pharmaceutical treatments generally fail to address the complex pathophysiology of chronic illnesses such as cancer, cardiovascular disorders, diabetes, and neurodegeneration.
Okechukwu Paul-Chima Ugwu, Melvin Nnaemeka Ugwu, Fabian C. Ogenyi, Esther Ugo Alum, Val Hyginus Udoka Eze, Mariam Basajja, Jovita Nnenna Ugwu, Michael Ben Okon, Chinyere N. Ugwu, Chinyere Nkemjika Anyanwu, Joseph Obiezu Chukwujekwu Ezeonwumelu, Dominic Terkimbi Swase, Bulhan Samanya, Simeon Ikechukwu Egba, Daniel Ejim Uti, Hope Onohuean   +15 more
doaj   +1 more source

Dioscin Promotes Ferroptosis in Cervical Cancer Cells via the TIGAR‐ROS Axis

Cancer Science, EarlyView.
Dioscin suppresses cervical cancer progression by promoting ferroptosis. Mechanistically, Dioscin binds to TIGAR and inhibits TIGAR function, elevating ROS levels and inducing ferroptosis. ABSTRACT Cervical cancer seriously threatens women's life and health, highlighting the urgent need for targeted therapies.
Yameng Liu, Hongli Xi, Shaoju Min, Hanlin Yang, Li Hou, Hailong Zhang, Yujie Tan   +6 more
wiley   +1 more source

Balanites aegyptiaca (L.) Delile: a review of its traditional uses, phytochemistry and biological activities

Phytomedicine Plus
Background: Balanites aegyptiaca, a member of the Zygophyllaceae family, has been utilized in traditional Ayurvedic medicine for over 4000 years. Various parts of B. aegyptiaca have been employed to treat a wide range of ailments, including leprosy, worm
A.S. Shinde, V.V. Ingole, S.P. Rasale, S.R. Katade   +3 more
doaj   +1 more source

Interaction of ceftriaxone and rutin with human serum albumin. WaterLOGSY-NMR and molecular docking study

, 2020
© 2019 Elsevier B.V. The NMR WaterLOGSY and molecular docking methods were used to study the interaction of human serum albumin (HSA) with two drugs of different chemical structures and properties, ceftriaxone and rutin.
Khairutdinov B., Ermakova E., Danilova A.   +2 more
core  

Purpurin Alleviates Meniscal Senescence and Osteoarthritis by Blocking the Non‐Metabolic Function of Hexokinase 2

Cell Proliferation, EarlyView.
HK2 is upregulated in osteoarthritis and accelerates disease progression via a glycolysis‐independent non‐metabolic mechanism. It recruits PRKN to degrade MYH10, reducing COL1A1 mRNA stability and inducing senescence. Purpurin disrupts this pathogenic pathway with therapeutic potential.
Zhencan Lin, Ming Li, Wei Li, Tianfa Xu, Zongrui Jiang, Yanlin Zhong, Aishan He, Xiaoyi Zhao, Dianbo Long, Yan Kang   +9 more
wiley   +1 more source

The Felicitous Success of the Subsection Molecular Oncology of International Journal of Molecular Sciences

, 2021
The evolvement of the newly started subsection IJMS molecular oncology is discussed. The breadth and depth of the journal articles is alluded to.
Michael Welsh, Welsh, Michael, Welsh, Michael,   +2 more
core   +1 more source

Bakuchiol: From structural mimicry to systems‐level skin biology

International Journal of Cosmetic Science, EarlyView.
Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley   +1 more source

Natural medicines for radioprotection and radiosensitization: a bibliometric analysis of mechanisms and trends (2001–2025)

Frontiers in Oncology
BackgroundIonizing radiation (IR) poses a global health threat, inducing molecular damage and chronic issues. Despite its significance, there has been limited bibliometric analysis to systematically evaluate the status, hotspots, and trends in the field ...
Yupeng Di, Yupeng Di, Yupeng Di, Jiazhao Song, Yingjie Wang, Lingling Meng, Jing Li, Jing Li   +7 more
doaj   +1 more source

In silico exploration of Lycoris alkaloids as potential inhibitors of SARS-CoV-2 main protease (Mpro)

European Journal of Biological Research, 2022
Coronavirus disease 2019 (COVID-19) is a pandemic whose adverse effects have been felt all over the world. As of August 2022, reports indicated that over 500 million people in the world had been infected and the number of rising deaths from the disease ...
Fredrick Mutie Musila, Grace W Gitau, Magrate M. Kaigongi, Dickson B. Kinyanyi, Jeremiah M. Mulu, Joseph M. Nguta   +5 more
doaj