Results 51 to 60 of about 13,074 (114)
Pharmacokinetic studies of (+)-JQ1, SAHA, and 009P1 in mice.
, 2023 Pharmacokinetic studies of (+)-JQ1, SAHA, and 009P1 in mice.
Tran Phuc (3948350) +10 more
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Scalable syntheses of the BET bromodomain inhibitor JQ1
, 2015 We have developed methods involving the use of alternate, safer reagents for the scalable syntheses of the potent BET bromodomain inhibitor JQ1. A one-pot three step method, involving the conversion of a benzodiazepine to a thioamide using Lawesson’s ...
Georg, Gunda I. +2 more
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Bewertung der Kombinationsbehandlung Docetaxel und JQ1 in präklinischen 2D- und 3D-Modellen von Prostatakrebs [PDF]
, 2023 Prostate cancer (PCa) remains the most prevalent cancer in men globally, with an increasing burden worldwide. PCa is unique in its dependence on androgen-androgen receptor (AR) signaling for growth and progression, and hormonal therapies have greatly ...
Xu, Yipeng
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JQ1 enhances the effects of HDAC3 depletion.
, 2014 A significant increase in GFP protein expression from the HIV-1 promoter was observed in 2D10 cells that had been depleted of HDAC3 and had been treated with JQ1 (50 nM) for 24 hours over cells that were transduced with the scrambled shRNA control and ...
Kirston M. Barton (618002) +8 more
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, 2023 Among the mechanisms involved in the progression of kidney disease, mitochondrial dysfunction has special relevance. Epigenetic drugs such as inhibitors of extra-terminal domain proteins (iBET) have shown beneficial effects in experimental kidney disease,
Marta Ruiz-Ortega +7 more
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Modulation of Virulence-Associated Traits in Aspergillus fumigatus by BET Inhibitor JQ1 [PDF]
, 2022 Aspergillus fumigatus is a disease-causing, opportunistic fungus that can establish infection due to its capacity to respond to a wide range of environmental conditions.
Palamara, Anna Teresa +25 more
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(+)-JQ1 attenuated LPS-induced microglial inflammation via MAPK/NFκB signaling
, 2018 Background Microglia activation is a crucial event in neurodegenerative disease. The depression of microglial inflammatory response is considered a promising therapeutic strategy.
Wenhai Huang +12 more
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Treatment with JQ1, a BET bromodomain inhibitor, is selectively detrimental to R6/2 Huntington’s disease mice [PDF]
, 2020 Transcriptional and epigenetic alterations occur early in Huntington's disease (HD), and treatment with epigenetic modulators is beneficial in several HD animal models.
Wu, Jie +10 more
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JQ1 suppresses tumor growth through downregulating LDHA in ovarian cancer
, 2015 Amplification and overexpression of c-Myc is commonly seen in human ovarian cancers, and this could be a potentially novel therapeutic target for this disease.
Zhou, Chunxiao +7 more
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, 2023 Additional file 1: Figure S1. Pharmaceutical drug screening and Depmap sgRNA screening indicated that epigenetic inhibitor JQ1 and cell cycle inhibition are more likely to be associated with joint lethality. A) Bar plot of the average and maximum synergy
Mei Feng (281903) +3 more
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