Results 61 to 70 of about 13,074 (114)

AMPK-ULK1-Mediated Autophagy Confers Resistance to BET Inhibitor JQ1 in Acute Myeloid Leukemia Stem Cells

open access: yes, 2017
Purpose: Bromodomain and extraterminal domain (BET) inhibitors are promising epigenetic agents for the treatment of various subsets of acute myeloid leukemia (AML).
민유홍   +4 more
core   +1 more source

lBromodomain inhibitor JQ1 reversibly blocks IFN-gamma production

open access: yes, 2019
As a class, 'BET' inhibitors disrupt binding of bromodomain and extra-terminal motif (BET) proteins, BRD2, BRD3, BRD4 and BRDT, to acetylated histones preventing recruitment of RNA polymerase 2 to enhancers and promoters, especially super-enhancers, to ...
Mi, Deborah J.   +5 more
core   +1 more source

Front Matter JKAP (Jurnal Kebijakan dan Administrasi Publik)

open access: yesJKAP (Jurnal Kebijakan dan Administrasi Publik), 2016
Front Matter JKAP (Jurnal Kebijakan dan Administrasi Publik)
Andri Putra Kesmawan
doaj  

Modernisasi Aspek Relasional Pemerintah Daerah: Menengok Sejarah, Menatap Masa Depan

open access: yesJKAP (Jurnal Kebijakan dan Administrasi Publik), 2015
The history of Nusantara was since 1600s broken down by the Europeans, so that it has developed not in a "natural" way, in which the governmental style in the independence Indonesia was always in the tendency to centralism, and this has demolished the ...
Samodra Wibawa
doaj   +1 more source

JQ1 suppresses tumor growth via PTEN/PI3K/AKT pathway in endometrial cancer

open access: yes, 2016
Overexpression of c-Myc is associated with worse outcomes in endometrial cancer, indicating that c-Myc may be a promising target for endometrial cancer therapy.
Clark, Leslie H.   +9 more
core   +1 more source

Desain Terbaru Sistem Manajemen Pegawai Negeri Sipil Di Indonesia (Telaah Kritis: Paradigma Baru"The New Public Service")

open access: yesJKAP (Jurnal Kebijakan dan Administrasi Publik), 2015
This brief article represent the idea brainstorming and interesting offers on submiting various alternative about the new design of management system of civil servant that proposed by observer and bureaucrats but apparently it can not touch the problems ...
M Nur Budiyanto
doaj   +1 more source

Arsenic sulfide combined with JQ1, chemotherapy agents, or celecoxib inhibit gastric and colon cancer cell growth

open access: yes, 2015
Lian Zhang,1 Yingying Tong,1 Xiuli Zhang,1 Minggui Pan,2,3 Siyu Chen1 1Department of Oncology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Department of Oncology and ...
Zhang X, Zhang L, Tong Y, Chen S, Pan M
core  

JQ1 increases BRD4 complex interaction with viral gene promoters.

open access: yes, 2016
HeLa cell were infected with HSV-1 at 10 MOI in the absence or presence of 500 nM JQ1 for 6 hr. Protein association and their interaction with viral gene promoters were determined by immunoprecipitation, by immunostaining, and by ChIP assays ...
Ke Ren (34504)   +8 more
core   +1 more source

Effects of bromodomain and extra-terminal inhibitor JQ1 and interleukin-6 on breast cancer cells

open access: yes, 2023
Background: Bromodomain and extra-terminal (BET) proteins are recognized acetylated lysine of histone 4 and act as scaffolds to recruit many other proteins to promoters and enhancers of active genes, especially at the super-enhancers of key genes ...
Jami, Mohammad-Saeid   +17 more
core   +1 more source

Smart Community Governance Dalam Program Geopark Ngarai Sianok di Kota Bukitting

open access: yesJAKP (Jurnal Administrasi dan Kebijakan Publik), 2019
Smart community governance merupakan suatu konsep dimana masyarakat atau kelompok pintar membantu pemerintah dalam memecahkan masalah. Pariwisata merupakan salah satu keunggulan dari kota Bukittinggi.
Utary Salsabila
doaj   +1 more source

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