Results 161 to 170 of about 13,555 (204)

Mechanistic insights and in vivo HIV suppression by the BRD4-targeting small molecule ZL0580. [PDF]

PLoS Pathog
Kumar N, Ma Z, Long F, Bonam SR, Lai HT, Wu SY, Chen H, Hazell NC, Bei J, Liu X, Chen Y, Wei Z, Chiang CM, Zhou J, Hu H.   +14 more
europepmc   +1 more source

Recent Progress and Prospect in Studying Selective Inhibitors Toward Bromodomain Family Members. [PDF]

Molecules
Chen J, Huang Y, Wang J, Yang W.
europepmc   +1 more source

MBD3 increased expression by BRD4 and facilitated castration-resistant prostate cancer cell proliferation by inhibiting PTEN. [PDF]

Discov Oncol
Pan L, Shen J, Li Z, Xie G, Chen C, Chen X.   +5 more
europepmc   +1 more source

Targeting BRD4-A Promising Therapeutic Option for Glioblastoma? [PDF]

Int J Mol Sci
Lindner M, Lisińska D, Kędzierzyńska A, Majchrzak-Celińska A.   +3 more
europepmc   +1 more source

MYC-Mediated Functional Manifestation of IDH1 Mutations in Intrahepatic Cholangiocarcinoma Confers Sensitivity to (+)-JQ1. [PDF]

Int J Biol Sci
Wang F, Liu X, Zhang N, Kong R.
europepmc   +1 more source

A General Photoredox Platform for the Hydroarylation of Olefins. [PDF]

J Am Chem Soc
Li YL, Wang JZ, MacMillan DWC.
europepmc   +1 more source

Parasite-specific essential bromodomain protein TgBDP4 is a key epigenetic reader and a potential drug target for the parasite Toxoplasma gondii. [PDF]

J Biol Chem
Gurupwar R, Khandavalli CR, Deshmukh AS.
europepmc   +1 more source

Global protein-ligand binding affinity profiling via photocatalytic labeling. [PDF]

Nat Commun
Warren CD, Yardeny N, Peng S, Burdette CS, Geri JB.   +4 more
europepmc   +1 more source

The Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis

Tissue Engineering and Regenerative Medicine, 2021
Ferroptosis is an iron-dependent, non-apoptotic programmed cell death. Cellular senescence contributes to aging and various age-related diseases through the expression of a senescence-associated secretory phenotype (SASP). Senescent cells are often resistant to ferroptosis via increased ferritin and impaired ferritinophagy.
Byung-Soo Kim, Mungyo Jung, Mikyung Kang
exaly   +4 more sources

Protective effect of the BET protein inhibitor JQ1 in cisplatin-induced nephrotoxicity [PDF]

American Journal of Physiology - Renal Physiology, 2018
As a potent chemotherapy drug, cisplatin is also notorious for its side-effects including nephrotoxicity in kidneys, presenting a pressing need to identify renoprotective agents. Cisplatin nephrotoxicity involves epigenetic regulations, including changes in histone acetylation.
Liping Sun, Zheng Dong
exaly   +4 more sources