Results 161 to 170 of about 14,237 (205)

Modular Assembled Targeting Chimera Enables Multimodal Targeted Protein Degradation. [PDF]

JACS Au
Zhu W, Zhang W, Wang Y, Chen J, Xu F, Pang J.   +5 more
europepmc   +1 more source

Epigenetic profiling reveals key super-enhancer networks driving oncogenesis in HPV-positive HNSCC. [PDF]

iScience
Zamuner FT, Chan SS, Kessler MD, Vorontsov IE, Loginov A, Erbe R, Imada E, Xie DX, Guo T, Fertig EJ, Kulakovskiy IV, Danilova L, Favorov AV, Gaykalova DA.   +13 more
europepmc   +1 more source

Systematic Characterization of Cancer-Associated SPOP Mutants Reveals Novel and Reprogrammable Degradative Activities. [PDF]

Chembiochem
Caldwell AG, Parmar H, Jin X, Zhou C, Zhang X.   +4 more
europepmc   +1 more source

[Inhibition of BRD4 promotes migration of esophageal squamous cell carcinoma cells with low ACC1 expression]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Jia W, Huo S, Tang J, Liu Y, Zhao B.
europepmc   +1 more source

Correction: Jaksic Karisik et al. JQ1 Treatment and miR-21 Silencing Activate Apoptosis of CD44+ Oral Cancer Cells. <i>Int. J. Mol. Sci.</i> 2025, <i>26</i>, 1241. [PDF]

Int J Mol Sci
Jaksic Karisik M, Lazarevic M, Mitic D, Ajtic OM, Damante G, Milasin J.   +5 more
europepmc   +1 more source

CDK4/6 and BET inhibitors synergistically suppress pancreatic tumor growth and epithelial-to-mesenchymal transition by regulating the GSK3β-mediated Wnt/β-catenin pathway. [PDF]

Cancer Drug Resist
Gu J, Dai Z, Shen T, Chen X, Yang Z, Sun S, Chen D, Luo H, Wang X, Xu J.   +9 more
europepmc   +1 more source

The Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis

Tissue Engineering and Regenerative Medicine, 2021
Ferroptosis is an iron-dependent, non-apoptotic programmed cell death. Cellular senescence contributes to aging and various age-related diseases through the expression of a senescence-associated secretory phenotype (SASP). Senescent cells are often resistant to ferroptosis via increased ferritin and impaired ferritinophagy.
Mikyung Kang, Mungyo Jung, Ok Hee Jeon
exaly   +4 more sources

JQ1 attenuates psychostimulant- but not opioid-induced conditioned place preference

Behavioural Brain Research, 2022
Epigenetic mechanisms play important roles in the neurobiology of substance use disorder. In particular, bromodomain and extra-terminal domain (BET) proteins, a class of histone acetylation readers, have been found to regulate cocaine conditioned behaviors, but their role in the behavioral response to other drugs of abuse remains unclear.
C J, Babigian, H J, Wiedner, C, Wahlestedt, G C, Sartor   +3 more
openaire   +3 more sources