Results 141 to 150 of about 13,555 (204)

IL-26-driven epigenetic remodeling promotes immune evasion in colorectal cancer. [PDF]

Nat Commun
Itoh T, Hatano R, Hasegawa Y, Hosokawa N, Takeda K, Yamamoto A, Horimoto Y, Yu J, Nakamura H, Saeki H, Ehata S, Matsuoka S, Otsuka H, Ohtsu H, Tomura M, Dang NH, Kaneko Y, Ohnuma K, Morimoto C.   +18 more
europepmc   +1 more source

The DCBLD2 super-enhancer drives colorectal cancer progression through FOSL2/JUND-mediated activation of the CD146/AKT/TNFRSF6B pathway. [PDF]

Mol Biomed
Wu T, Shao L, Hu X, He H, Chen L, Feng M, Qi C, Wang Z, Yu H, Ji B, Cao Y, Zhang Y, Wu Q.   +12 more
europepmc   +1 more source

BRD4 Inhibition alleviates sepsis-associated acute kidney injury via suppression of NOX4-mediated oxidative stress and inflammation. [PDF]

Cell Death Discov
Jia J, Ji K, Zhou Y, Huang Y, Li A, Ye F, Huang W, Chen F, Lu G.   +8 more
europepmc   +1 more source

Meiotic prophase I disruption as a strategy for nonhormonal male contraception using small-molecule inhibitor JQ1. [PDF]

Proc Natl Acad Sci U S A
Tanis S, Simon LE, Alexander AK, Horan TS, Carro MLM, Bonnett SJ, Xie A, Ben-Shlomo R, Owens CE, Danko CG, Lujic J, Cohen PE.   +11 more
europepmc   +1 more source

BRD4 PROTAC degrader enhances fulvestrant sensitivity in ER+ breast cancer via super-enhancer associated GREB1. [PDF]

Front Oncol
Zhang X, Zheng P, Liu Z, Zhang Q, Duan W, Zhang T, Liu X.   +6 more
europepmc   +1 more source

NHWD-870, a Potent BET Inhibitor, Ameliorated Endotoxemia-Induced Hepatic Inflammation via Suppression of BRD4-STAT1 Signaling and Macrophage M1 Polarization. [PDF]

J Inflamm Res
Zhou N, Tan B, Jiang Y, Wang H, Peng W, Yin M, Fu L, Peng S.   +7 more
europepmc   +1 more source

BET inhibition disrupts the FOXM1-MYC axis to induce BRCAness and enhance PARP inhibitor response. [PDF]

NPJ Precis Oncol
Fang P, Saunders A, Minn K, Chua KJ, Brooks RA, Bakke D, Leiserowitz GS, Johnson N, Wang S, Chien J.   +9 more
europepmc   +1 more source

Multistage responsive microneedle delivery system loaded oncolytic virus for topical therapy of melanoma. [PDF]

Acta Pharm Sin B
Wang Z, Yan Z, Chen H, Wang Y, Shi Y, Jing Y, Ming R, Liu S, Jin P, Wu G, Huang L.   +10 more
europepmc   +1 more source

Harnessing MDM2-Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma. [PDF]

Adv Sci (Weinh)
Zhou J, Guan X, Li N, Zhang Y, Xie L, Huang X, Zhu Z, Ren Z, Yu X, Guo H, Wu Y, Ma L, Zheng S, Zhang J, Liu J, Lee VK, Chen W, Koeffler HP, Wang J, Han X, Chen Y, Xu L.   +21 more
europepmc   +1 more source

BromoCatch: a self-labelling tag platform for protein modification and live cell imaging. [PDF]

Nat Commun
Rodriguez-Rios M, Craigon C, Nakasone MA, Sathe G, Bond AG, Dorward M, Edmonds AK, Norley MC, Arnold RE, Wood PM, Reynolds SJ, Cresser-Brown JO, Marsh GP, Maple HJ, Ciulli A.   +14 more
europepmc   +1 more source