Results 121 to 130 of about 13,555 (204)

Supplementary Figures S1-S5 and Legends from AMPK–ULK1-Mediated Autophagy Confers Resistance to BET Inhibitor JQ1 in Acute Myeloid Leukemia Stem Cells

, 2017
Supplementary figure S1. Differential sensitivity of human AML LSCs to JQ1. Supplementary figure S2. Relative levels of the autophagy pathway effectors LC3-II, beclin-1, and pULK1 (S555). Supplementary figure S3. Autophagy induction in KG1 and KG1a cells
Ji Eun Jang (8135850), Ju-In Eom (519760), Yoo Hong Min (8717373), June-Won Cheong (519759), Jung Yeon Lee (12355078), Jin Seok Kim (8717370), Hoi-Kyung Jeung (519761)   +6 more
core   +1 more source

Chemical Catalysis Guides Structural Identification for the Major In Vivo Metabolite of the BET Inhibitor JQ1

The bromodomain inhibitor (+)-JQ1 is a highly validated chemical probe; however, it exhibits poor in vivo pharmacokinetics. To guide efforts toward improving its pharmacological properties, we identified the (+)-JQ1 primary metabolite using chemical ...
Feng Li (30515), Srinivas Chamakuri (1554262), Christian Cerda-Smith (17720062), Jade Williams (17720059), Damian W. Young (1271631), Secondra Holmes (17720053), Kevin R. MacKenzie (2368375), Diana Monsivais (187659), Zhifeng Yu (644059), Conrad Santini (1887550), James Campbell (81613), Kenneth Guzman Rodriguez (17720056), Errol L. G. Samuel (17720065), John Michael Hakenjos (17720068), Martin M. Matzuk (200210), Prashi Jain (1514275)   +15 more
core   +1 more source

SP048THE BET BROMODOMAIN INHIBITOR JQ1 DIMINISHED RENAL FIBROSIS [PDF]

Nephrology Dialysis Transplantation, 2016
Sandra Rayego-Mateos, José Luis Morgado-Pascual, Beatriz Suarez-Alvarez Suarez-Alvarez, Macarena Orejudo, Raúl R. Rodrigues-Díez, Laura Marquez-Exposito, Jesús Egido, Alberto Ortiz, Carlos Lopez-Larrea, Marta Ruiz-Ortega   +9 more
openaire   +1 more source

The MYC-independent effects of BET inhibitor JQ1 on super-enhancers in cancer

, 2019
MYC overexpression plays an important role in cancer progression and is a common feature of many cancer types. One reason is due to the invasion of super-enhancer regions by MYC upstream of oncogenes, often resulting in activation of oncogenic pathways ...
Chia, Boon Jun
core  

BRD4 inhibition mitigates acute and chronic corneal injury following topical nitrogen mustard exposure. [PDF]

Mol Ther
Lu Z, Shi S, Xia F, Krishna Chandran AM, Lin J, Iniguez DJ, Motamedi M, Liu H, Zhang W.   +8 more
europepmc   +1 more source

Cell type-selective targeting by heterobifunctional protein binders via in-cell enrichment. [PDF]

Nat Commun
Bulldan A, Zheng M, Meyners C, Purder PL, Krieger J, Dreizler JK, Geiger TM, Repity ML, Lein MH, Quist-Løkken I, Tewes N, Smith ER, Schwab K, Fischer M, Schwalm MP, Dey R, Aswathaman Sivashanmugam S, Schlesiger S, Moniot S, Knapp S, Hartung IV, Holien T, Loewer A, Hausch F.   +23 more
europepmc   +1 more source

Bromodomain Inhibitor JQ1 Modulates Collagen Processing and Ameliorates Bleomycin Induced Dermal Fibrosis in Mice

, 2014
Background/Purpose: Systemic sclerosis (SSc) is a complex pro-inflammatory scarring disease, characterised by elevated deposition of extracellular matrix (ECM) proteins, in particular collagen type I.
Holmes, A, Trinder, S, Shi-Wen, X, Abraham, D, Gilbane, A, Good, A, Tarriela, M   +6 more
core  

Plasticity of extrachromosomal DNA segregation during drug adaptation. [PDF]

Nat Commun
Shibata C, Miyata K, Akao M, Kumegawa K, Maruyama Y, Yang L, Nagamoto M, Nozawa RS, Hirota T, Iwami S, Iwanami S, Maruyama R.   +11 more
europepmc   +1 more source

Bridging BET bromodomain and immune checkpoint inhibitors through generative bioorganic frameworks for next-generation cancer immunotherapy. [PDF]

RSC Med Chem
Diab MK, Yassen ASA, Fahmy SA, Ashour HF, Nafie MS.   +4 more
europepmc   +1 more source

Phase separation of ecDNA condensates establishes in-trans contact domains that boost selective MYC regulatory interactions. [PDF]

Nat Commun
Conte M, Al Hasani L, Matteuzzi T, Esposito A, Kundu S, Chiariello AM, Bianco S, Vercellone F, Li W, Nicodemi M.   +9 more
europepmc   +1 more source