Results 111 to 120 of about 14,237 (205)
The bromodomain inhibitor (+)-JQ1 is a highly validated chemical probe; however, it exhibits poor in vivo pharmacokinetics. To guide efforts toward improving its pharmacological properties, we identified the (+)-JQ1 primary metabolite using chemical ...
Feng Li (30515) +15 more
core +1 more source
Effects of JQ1 on P-TEFb occupancy.
, 2014 BAL17 and Raji cells were either untreated or treated with 1 µM of JQ1 for 2 hours. Recruitment of P-TEFb was detected by ChIP assays. Each experiment was analyzed in triplicate via real-time PCR, performed twice, and is reported as the mean and standard
David H. Price (31011) +8 more
core +1 more source
BET bromodomain inhibitor (JQ1) and tumor angiogenesis
Oncoscience, 2016 Bid, Hemant Kumar, Kerk, Samuel
openaire +2 more sources
Releasing Brd4 from chromatin by JQ1(+) abolishes the E2-Brd4 interaction on mitotic chromosomes.
, 2013 (A) C33A cells were co-transfected with VN-Brd4 and VC-16E2 and treated with 500 nM JQ1(-) or JQ1(+) at 24h post transfection. Forty-eight hours post-transfection, cells were either fixed immediately (before wash) or washed several times and cultured ...
Ranran Wang (476935) +2 more
core +1 more source
, 2017 Supplementary figure S1. Differential sensitivity of human AML LSCs to JQ1. Supplementary figure S2. Relative levels of the autophagy pathway effectors LC3-II, beclin-1, and pULK1 (S555). Supplementary figure S3. Autophagy induction in KG1 and KG1a cells
Ji Eun Jang (8135850) +6 more
core +1 more source
Effects of JQ1 on H3K36me3 status.
, 2014 Cells were either untreated or treated with 1 µM of JQ1 for 2 hours. ChIP assays were performed in duplicate. Each experiment was analyzed in triplicate via real-time PCR, performed twice, and is reported as the mean and standard deviation of the two ...
David H. Price (31011) +8 more
core +1 more source
The MYC-independent effects of BET inhibitor JQ1 on super-enhancers in cancer
, 2019 MYC overexpression plays an important role in cancer progression and is a common feature of many cancer types. One reason is due to the invasion of super-enhancer regions by MYC upstream of oncogenes, often resulting in activation of oncogenic pathways ...
Chia, Boon Jun
core
Inhibidores BET. El singular compuesto (+)-JQ1
, 2015 The serendipitous discovery of (bromodomain extra-terminal) (BET) inhibitors, especially of the BRD4 bromodomain inhibitors, has allowed modulation of gene transcription with epigenetic drugs.
Avendaño, Carmen
core
, 2014 Background/Purpose: Systemic sclerosis (SSc) is a complex pro-inflammatory scarring disease, characterised by elevated deposition of extracellular matrix (ECM) proteins, in particular collagen type I.
Holmes, A +6 more
core