Results 101 to 110 of about 13,555 (204)

Combination BET Family Protein and HDAC Inhibition Synergistically Elicits Chondrosarcoma Cell Apoptosis Through RAD51-Related DNA Damage Repair

Cancer Management and Research, 2020
Songwei Huan,1,* Tao Gui,1,* Qiutong Xu,1,* Songkuan Zhuang,2 Zhenyan Li,1 Yuling Shi,3 Jiebin Lin,3 Bin Gong,1 Guiqiang Miao,1 Manseng Tam,4 Huan-Tian Zhang,1 Zhengang Zha,1 Chunfei Wu3 1Institute of Orthopedic Diseases and Department of Bone and Joint ...
Huan S, Gui T, Xu Q, Zhuang S, Li Z, Shi Y, Lin J, Gong B, Miao G, Tam M, Zhang HT, Zha Z, Wu C   +12 more
doaj  

BET-inhibition by JQ1 promotes proliferation and self-renewal capacity of hematopoietic stem cells

Haematologica, 2018
Although inhibitors of bromodomain and extra terminal domain (BET) proteins show promising clinical activity in different hematologic malignancies, a systematic analysis of the consequences of pharmacological BET inhibition on healthy hematopoietic (stem)
Mark Wroblewski, Marina Scheller-Wendorff, Florian Udonta, Raimund Bauer, Jara Schlichting, Lin Zhao, Isabel Ben Batalla, Victoria Gensch, Sarina Päsler, Lei Wu, Marek Wanior, Hanna Taipaleenmäki, Simona Bolamperti, Zeynab Najafova, Klaus Pantel, Carsten Bokemeyer, Jun Qi, Eric Hesse, Stefan Knapp, Steven Johnsen, Sonja Loges   +20 more
doaj   +1 more source

Reactive Oxygen Species in Breast Cancer: From Redox Dysregulation to ROS‐Responsive Therapeutics

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Breast cancer is the most frequently diagnosed malignancy among women worldwide, with 2.3 million new cases and approximately 670,000 deaths reported in 2022 alone. Despite advances in therapy, metastasis and acquired drug resistance remain major clinical challenges.
Marija Nikolovska, Radoslav Stojchevski, Aleksandar Eftimov, Mitko Mladenov, Dimiter Avtanski, Nikola Hadzi‐Petrushev   +5 more
wiley   +1 more source

JQ1 increases BRD4 complex interaction with viral gene promoters.

, 2016
HeLa cell were infected with HSV-1 at 10 MOI in the absence or presence of 500 nM JQ1 for 6 hr. Protein association and their interaction with viral gene promoters were determined by immunoprecipitation, by immunostaining, and by ChIP assays ...
Ke Ren (34504), Yayi Hou (139450), Erguang Li (367297), Xiaoqing Chen (89898), Wei Zhang (405), Yue Dai (287672), Ren Xiang Tan (1633183), Yingyu Ma (3229974), Yimei Fan (615439)   +8 more
core   +1 more source

Mitochondria‐targeted nanomedicine for cancer therapy: Targeting strategies, therapeutic mechanisms, and translational challenges

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
This review highlights recent advances in mitochondria‐targeted nanomedicine for cancer therapy. It summarizes key targeting strategies and delineates four principal therapeutic mechanisms: oxidative stress–induced mitochondrial dysfunction, disruption of energy metabolism, direct mitochondrial damage, and induction of immunogenic cell death.
Linfeng Xiao, Xiaowei Chang, Jun Zhang, Yinshan Hong, Wenhui Cao, Zhewu Zhao, Yu‐E. Wang, Yanling Yang   +7 more
wiley   +1 more source

Additional file 1 of The BRD4 inhibitor JQ1 augments the antitumor efficacy of abemaciclib in preclinical models of gastric carcinoma

, 2023
Additional file 1: Figure S1. Pharmaceutical drug screening and Depmap sgRNA screening indicated that epigenetic inhibitor JQ1 and cell cycle inhibition are more likely to be associated with joint lethality. A) Bar plot of the average and maximum synergy
Mei Feng (281903), Hao Xu (6530), Wenyuan Zhou (9733194), Yisheng Pan (15217730)   +3 more
core   +1 more source

Registered report: BET bromodomain inhibition as a therapeutic strategy to target c-Myc

eLife, 2015
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by replicating selected results from a substantial number of high-profile papers in the field of cancer biology published between ...
Irawati Kandela, Hyun Yong Jin, Katherine Owen, Reproducibility Project: Cancer Biology   +3 more
doaj   +1 more source

Prostate Cancer Development, Progression, and Therapy

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin, Zicheng Xiao, Zexian Ding, Wei Li, Ruijiang Zeng, Yujun Shuai, Weimin Ci, Dan Xia, Xu Zhang, Haojie Huang   +9 more
wiley   +1 more source

JQ1 alters epigenomic programming of KSHV latency control region.

, 2017
(A) Schematic of KSHV genome and primer positions a-h used for ChIP assays. (B-H) BCBL1 cells treated with 1% DMSO or 4uM JQ1 for 1 hr were assayed by ChIP for IgG or (B) BRD4, (C) BRD2, (D) CTCF (E) Rad21 (F) RNAPII, (G) H3AcK9, or (H) LANA.
Horng-Shen Chen (473322), Robert Hills (3685870), Paul M. Lieberman (56113), Zhuo Wang (18668), Alessandra De Leo (3685876), Andrew Kerekovic (3685873)   +5 more
core   +1 more source

A Physical Organic Odyssey: From the Ultrafast Dynamics of Carbenes and Nitrenes to Contemporary Chemical Biology and Drug Discovery

Journal of Physical Organic Chemistry, Volume 39, Issue 9, September 2026.
Physical organic chemistry transforms photoaffinity labeling from empirical photochemistry into rational probe design. By measuring reactive‐intermediate lifetimes, pathways, and selectivity, Platz's legacy connects carbene and nitrene mechanisms to modern chemoproteomics, enabling more precise protein labeling and drug‐discovery maps.
Bin Yang, Jin Wang
wiley   +1 more source