Results 91 to 100 of about 13,555 (204)

From biochemical time–resolved fluorescence resonance energy transfer assay to live cell nanobio-luminescence resonance energy transfer assay: A case study with the bromodomain-containing protein 4 protein

ASPET Discovery
Fluorescent probe–based time-resolved fluorescence resonance energy transfer (TR-FRET) biochemical assays are widely used in characterizing ligands’ binding activities, whereas fluorescent probe–based nanobio-luminescence resonance energy transfer ...
Wenwei Lin, Young-Hwan Jung, Yongtao Li, Lei Yang, Taosheng Chen   +4 more
doaj   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Bromodomain and extraterminal protein inhibitor JQ1 induces maturation arrest and disrupts the cytoplasmic organization in mouse oocytes under in vitro conditions

Scientific Reports
JQ1, a small cell-permeable molecule is known for its potent inhibitory action on bromodomain and extraterminal (BET) proteins. Although earlier studies have shown its inhibitory effect on male gametogenesis, limited information is available about its ...
Keerthana Karunakar Poojary, Jyolsna Ponnaratta Kunhiraman, Vanishree Vasave Madhvacharya, Sandhya Kumari, Navami Krishna, Suresh P S, Rajanikant G K, Srinivas Mutalik, Nadeem Khan Ghani, Shama Prasada Kabekkodu, Thottethodi Subrahmanya Keshava Prasad, Satish Kumar Adiga, Guruprasad Kalthur   +12 more
doaj   +1 more source

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface‐Condensate Trajectory

Advanced Science, Volume 13, Issue 49, 3 September 2026.
Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg, Irina Wachter, Agnieszka Pancholi, Matthias Akyel, Yomna Gohar, Priya Kumar, Ana Miguel Fernandes, Yuzhi Bao, Alica Schmidt‐Heydt, Marcel Piepers, Alicia Günthel, Marcel Sobucki, Elisa Kämmer, Süheyla Eroğlu‐Kayıkçı, Stephan Allgeier, Sylvia Erhardt, Vasily Zaburdaev, Carmelo Ferrai, Lennart Hilbert   +18 more
wiley   +1 more source

AMPK-ULK1-Mediated Autophagy Confers Resistance to BET Inhibitor JQ1 in Acute Myeloid Leukemia Stem Cells

, 2017
Purpose: Bromodomain and extraterminal domain (BET) inhibitors are promising epigenetic agents for the treatment of various subsets of acute myeloid leukemia (AML).
민유홍, 장지은, 이정연, 정준원, 김진석   +4 more
core   +1 more source

Enhanced efficacy of histone deacetylase inhibitor combined with bromodomain inhibitor in glioblastoma

Journal of Experimental & Clinical Cancer Research, 2018
Background Glioblastoma (GBM) is the most common and most malignant primary brain cancer in adults. Despite multimodality treatment, the prognosis is still poor.
Wei Meng, Baocheng Wang, Weiwei Mao, Jiajia Wang, Yang Zhao, Qifeng Li, Chenran Zhang, Yujie Tang, Jie Ma   +8 more
doaj   +1 more source

Arsenic sulfide amplifies JQ1 toxicity via mitochondrial pathway in gastric and colon cancer cells

, 2018
Zhen Tan,* Xiuli Zhang,* Ting Kang, Lian Zhang, Siyu Chen Department of Oncology, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China *These authors contributed equally to this work Purpose: Gastric and colon ...
Tan Z, Kang T, Zhang X, Zhang L, Chen S
core  

Treatment with JQ1, a BET bromodomain inhibitor, is selectively detrimental to R6/2 Huntington’s disease mice [PDF]

, 2020
Transcriptional and epigenetic alterations occur early in Huntington's disease (HD), and treatment with epigenetic modulators is beneficial in several HD animal models.
Wu, Jie, Thompson, Leslie M, Stocksdale, Jennifer T, Reidling, Jack C, Adam, Miriam, Fraenkel, Ernest, Lim, Ryan G, Wassie, Brook T., Casale, Malcolm S, Kedaigle, Amanda J, Wassie, Brook   +10 more
core   +1 more source

Histone Post‐Translational Modifications Regulating Ferroptosis: The Molecular Mechanisms and Disease Associations

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Ferroptosis is a form of programmed cell death characterized by iron‐dependent phospholipid peroxidation and is implicated in a wide range of human diseases. Emerging evidence highlights the critical role of epigenetic regulation in this process.
Xiaoqian Tang, Haodang Luo, Siqi Gao, Xiaocheng Liu, Qing Sun, Yanhua Zeng   +5 more
wiley   +1 more source

Effects of bromodomain and extra-terminal inhibitor JQ1 and interleukin-6 on breast cancer cells

, 2023
Background: Bromodomain and extra-terminal (BET) proteins are recognized acetylated lysine of histone 4 and act as scaffolds to recruit many other proteins to promoters and enhancers of active genes, especially at the super-enhancers of key genes ...
Jami, Mohammad-Saeid, Soltani, Amin, Heshmati, Masoud, Hedayatollah Shirzad, Atefeh Sharifhoseini, Shirzad, Hedayatollah, Babri A. Judd, Entezam, Mahshad, Judd, Babri A., Ghatrehsamani, Mahdi, Amin Soltani, Mahshad Entezam, Mahdi Ghatrehsamani, Mohammad-Saeid Jami, Masoud Heshmati, Morteza Sedehi, Sharifhoseini, Atefeh, Sedehi, Morteza   +17 more
core   +1 more source