Results 21 to 30 of about 619 (135)

Functional Enrichment Analysis of Regulatory Elements

Biomedicines, 2022
Statistical methods for enrichment analysis are important tools to extract biological information from omics experiments. Although these methods have been widely used for the analysis of gene and protein lists, the development of high-throughput ...
Adrian Garcia-Moreno, Raul López-Domínguez, Juan Antonio Villatoro-García, Alberto Ramirez-Mena, Ernesto Aparicio-Puerta, Michael Hackenberg, Alberto Pascual-Montano, Pedro Carmona-Saez   +7 more
doaj   +1 more source

Progressive Reduction in Mitochondrial Mass Is Triggered by Alterations in Mitochondrial Biogenesis and Dynamics in Chronic Kidney Disease Induced by 5/6 Nephrectomy

Biology, 2021
The five-sixth nephrectomy (5/6Nx) model is widely used to study the mechanisms involved in chronic kidney disease (CKD) progression. Mitochondrial impairment is a critical mechanism that favors CKD progression.
Rodrigo Prieto-Carrasco, Fernando E. García-Arroyo, Omar Emiliano Aparicio-Trejo, Pedro Rojas-Morales, Juan Carlos León-Contreras, Rogelio Hernández-Pando, Laura Gabriela Sánchez-Lozada, Edilia Tapia, José Pedraza-Chaverri   +8 more
doaj   +1 more source

Key concepts and a world-wide look at plant recruitment networks. [PDF]

Biol Rev Camb Philos Soc
ABSTRACT Plant–plant interactions are major determinants of the dynamics of terrestrial ecosystems. There is a long tradition in the study of these interactions, their mechanisms and their consequences using experimental, observational and theoretical approaches.
Alcántara JM, Verdú M, Garrido JL, Montesinos-Navarro A, Aizen MA, Alifriqui M, Allen D, Al-Namazi AA, Armas C, Bastida JM, Bellido T, Paterno GB, Briceño H, Camargo de Oliveira RA, Campoy JG, Chaieb G, Chu C, Constantinou E, Delalandre L, Duarte M, Faife-Cabrera M, Fazlioglu F, Fernando ES, Flores J, Flores-Olvera H, Fodor E, Ganade G, Garcia MB, García-Fayos P, Gavini SS, Goberna M, Gómez-Aparicio L, González-Pendás E, González-Robles A, İpekdal K, Kikvidze Z, Ledo A, Lendínez S, Liu H, Lloret F, López RP, López-García Á, Lortie CJ, Losapio G, Lutz JA, Máliš F, Manzaneda AJ, Marcilio-Silva V, Michalet R, Molina-Venegas R, Navarro-Cano JA, Novotny V, Olesen JM, Ortiz-Brunel JP, Pajares-Murgó M, Perea AJ, Pérez-Hernández V, Pérez-Navarro MÁ, Pistón N, Prieto I, Prieto-Rubio J, Pugnaire FI, Ramírez N, Retuerto R, Rey PJ, Rodriguez-Ginart DA, Sánchez-Martín R, Tavşanoğlu Ç, Tedoradze G, Tercero-Araque A, Tielbörger K, Touzard B, Tüfekcioğlu İ, Turkis S, Usero FM, Usta-Baykal N, Valiente-Banuet A, Vargas-Colin A, Vogiatzakis I, Zamora R.   +79 more
europepmc   +2 more sources

KRAS and BRAF somatic mutations in colonic polyps and the risk of metachronous neoplasia. [PDF]

PLoS ONE, 2017
High-risk features of colonic polyps are based on size, number, and pathologic characteristics. Surveillance colonoscopy is often recommended according to these findings. This study aimed to determine whether the molecular characteristics of polyps might
Miriam Juárez, Cecilia Egoavil, María Rodríguez-Soler, Eva Hernández-Illán, Carla Guarinos, Araceli García-Martínez, Cristina Alenda, Mar Giner-Calabuig, Oscar Murcia, Carolina Mangas, Artemio Payá, José R Aparicio, Francisco A Ruiz, Juan Martínez, Juan A Casellas, José L Soto, Pedro Zapater, Rodrigo Jover   +17 more
doaj   +1 more source

Therapeutic Effect of Curcumin on 5/6Nx Hypertriglyceridemia: Association with the Improvement of Renal Mitochondrial β-Oxidation and Lipid Metabolism in Kidney and Liver

Antioxidants, 2022
Chronic kidney disease (CKD) prevalence is constantly increasing, and dyslipidemia in this disease is characteristic, favoring cardiovascular events. However, the mechanisms of CKD dyslipidemia are not fully understood.
Zeltzin Alejandra Ceja-Galicia, Fernando Enrique García-Arroyo, Omar Emiliano Aparicio-Trejo, Mohammed El-Hafidi, Guillermo Gonzaga-Sánchez, Juan Carlos León-Contreras, Rogelio Hernández-Pando, Martha Guevara-Cruz, Armando R. Tovar, Pedro Rojas-Morales, Ana Karina Aranda-Rivera, Laura Gabriela Sánchez-Lozada, Edilia Tapia, José Pedraza-Chaverri   +13 more
doaj   +1 more source

Leaf d15N as a physiological indicator of the responsiveness of N2-fixing alfalfa plants to elevated [CO2], temperature and low water availability

Frontiers in Plant Science, 2015
The natural 15N/14N isotope composition (δ15N) of a tissue is a consequence of its N source and N physiological mechanisms in response to the environment.
Idoia eAriz, Cristina eCruz, Tome eNeves, Juan J. Irigoyen, Carmen eGarcía, Salvador eNogués, Pedro M Aparicio-Tejo, Iker eAranjuelo   +7 more
doaj   +1 more source

Assessment of NASA SMAP Soil Moisture Products for Agricultural Regions in Central Mexico: An Analysis Based on the THEXMEX Dataset

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2022
Accurate knowledge of soil moisture (SM) is crucial in hydrological, micrometeorological, and agricultural applications; however, the SM estimation is particularly challenging in agricultural regions due to high spatial variability and dynamic vegetation
Alejandro Monsivais-Huertero, Daniel Enrique Constantino-Recillas, Juan Carlos Hernandez-Sanchez, Hector Ernesto Huerta-Batiz, Jasmeet Judge, Pedro Alejandro Lopez-Estrada, Jose Carlos Jimenez-Escalona, Eduardo Arizmendi-Vasconcelos, Marco Antonio Garcia-Bernal, Cira Francisca Zambrano-Gallardo, Alejandra Aurelia Lopez-Caloca, Enrique Zempoaltecatl-Ramirez, Ivan Edmundo De la Rosa-Montero, Roberto Ivan Villalobos-Martinez, Ramon Sidonio Aparicio-Garcia, Carlos Rodolfo Sanchez-Villanueva, Leonardo Arizmendi-Vasconcelos, Roberto Cotero-Manzo, Jaime Hugo Puebla-Lomas, Victor Manuel Sauce-Rangel   +19 more
doaj   +1 more source

Cost-Effectiveness of Once-Daily Single-Inhaler COPD Triple Therapy in Spain: IMPACT Trial

International Journal of COPD, 2022
Victoria Federico Paly,1 Laura Amanda Vallejo-Aparicio,2 Alan Martin,3 José Luis Izquierdo,4 Juan Antonio Riesco,5 Juan José Soler-Cataluña,6 Catarina Abreu,7 Chandroday Biswas,8 Afisi S Ismaila9,10 1ICON plc, Philadelphia, PA, USA; 2GSK, Madrid, Spain ...
Paly VF, Vallejo-Aparicio LA, Martin A, Izquierdo JL, Riesco JA, Soler-Cataluña JJ, Abreu C, Biswas C, Ismaila AS   +8 more
doaj  

Transcriptional regulation by Poly(ADP-ribose) polymerase-1 during T cell activation

BMC Genomics, 2008
Background Accumulating evidence suggests an important role for the enzyme poly(ADP-ribose) polymerase-1 (PARP-1) as an integral part of the gene expression regulatory machinery during development and in response to specific cellular signals.
Parrilla Pascual, Ramirez Pablo, Baroja-Mazo Alberto, Valdor Rut, Lozano Juan J, Saenz Luis, Aparicio Pedro, Sumoy Lauro, Yélamos José   +8 more
doaj   +1 more source

Efficacy and safety of intramuscular administration of allogeneic adipose tissue derived and expanded mesenchymal stromal cells in diabetic patients with critical limb ischemia with no possibility of revascularization: study protocol for a randomized controlled double-blind phase II clinical trial (The NOMA Trial)

Trials, 2021
Background Chronic lower limb ischemia develops earlier and more frequently in patients with type 2 diabetes mellitus. Diabetes remains the main cause of lower-extremity non-traumatic amputations.
Barbara Soria-Juan, Mariano Garcia-Arranz, Lucía Llanos Jiménez, César Aparicio, Alejandro Gonzalez, Ignacio Mahillo Fernandez, Luis Riera del Moral, Lukasz Grochowicz, Enrique J. Andreu, Pedro Marin, Gregorio Castellanos, Jose Maria Moraleda, Ana Maria García-Hernández, Francisco S. Lozano, Fermin Sanchez-Guijo, Eva María Villarón, Miriam Lopez Parra, Rosa María Yañez, Antonio de la Cuesta Diaz, Juan Rigoberto Tejedo, Francisco J. Bedoya, Franz Martin, Manuel Miralles, Lourdes del Rio Sola, María Eugenia Fernández-Santos, José Manuel Ligero, Francisco Morant, Luis Hernández-Blasco, Etelvina Andreu, Abdelkrim Hmadcha, Damian Garcia-Olmo, Bernat Soria   +31 more
doaj   +1 more source