Results 141 to 150 of about 2,148,903 (315)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Cards Against Pulmonology. [PDF]

J Educ Teach Emerg Med
Lamparter L, Wray A.
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Evaluating Medical Text Summaries Using Automatic Evaluation Metrics and LLM-as-a-Judge Approach: A Pilot Study. [PDF]

Diagnostics (Basel)
Vasilev Y, Raznitsyna I, Pamova A, Burtsev T, Bobrovskaya T, Kosov P, Vladzymyrskyy A, Omelyanskaya O, Arzamasov K.   +8 more
europepmc   +1 more source

Farrell Sacks, Plaintiff, -against- Gandhi Engineering Inc., Defendant. [PDF]

, 2013
Freeman, Judge Debra
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Spontaneous Expulsion of a Sebaceous Cyst: A Case Report of a Rare Surgical Outcome. [PDF]

Cureus
Gill MS, Cheema P.
europepmc   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Automating expert-level medical reasoning evaluation of large language models. [PDF]

NPJ Digit Med
Zhou S, Xie W, Li J, Zhan Z, Song M, Yang H, Espinoza C, Welton L, Mai X, Jin Y, Xu Z, Chung YH, Xing Y, Tsai MH, Schaffer E, Shi Y, Liu N, Liu Z, Zhang R.   +18 more
europepmc   +1 more source

EEOC v. Sunrise Hospitality BC II, LLC d/b/a Microtel Inns & Suites [PDF]

, 2007
Hicks, Judge Maurice
core   +1 more source