Results 21 to 30 of about 801,780 (219)

Rapid detection of carbapenem-resistant Escherichia coli and carbapenem-resistant Klebsiella pneumoniae in positive blood cultures via MALDI-TOF MS and tree-based machine learning models

BMC Microbiology
Background Bloodstream infection (BSI) is a systemic infection that predisposes individuals to sepsis and multiple organ dysfunction syndrome. Early identification of infectious agents and determination of drug-resistant phenotypes can help patients with
Xiaobo Xu, Zhaofeng Wang, Erjie Lu, Tao Lin, Hengchao Du, Zhongfei Li, Jiahong Ma   +6 more
doaj   +1 more source

Prevalence, antibiotic resistance and molecular characterization of Staphylococcus aureus in ready-to-eat fruits and vegetables in Shanghai, China

Current Research in Food Science
Staphylococcus aureus (S. aureus) is one of the foodborne pathogens. This study aimed to investigate the prevalence of S. aureus in ready-to-eat (RTE) fruits and vegetables in Shanghai, China.
Kai Jia, Xiaojie Qin, Xiangfeng Bu, Huajian Zhu, Yangtai Liu, Xiang Wang, Zhuosi Li, Qingli Dong   +7 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Distribution of gut microbiota and prognostic value in elderly patients with coronary atherosclerosis: a preliminary culture-based study

BMC Cardiovascular Disorders
Objective This study aimed to characterize the distribution of specific cultivable gut microbiota in elderly patients with coronary artery disease (CAD) and evaluate their prognostic significance. Methods A cohort of 200 elderly CAD patients, categorized
Hengchao Du, Xiaobo Xu, Qunyan Lei, Chengsi Qian, Zhaofeng Wang, Xinyan Yu, Qunfang Lei   +6 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Tunable-Charge Optical Vortices Through Edge Diffraction of a High-Order Hermit-Gaussian Mode Laser

Photonics
An optical vortex is a typical structured light field characterized by a helical wavefront and a central phase singularity. With its expanding applications in modern information technology, the demand for generating vortex beams with diverse topological ...
Shuaichen Li, Yiyang Zhang, Ying Li, Linge Mao, Pengfan Zhao, Zhen Qiao   +5 more
doaj   +1 more source

Scene Classification from Synthetic Aperture Radar Images Using Generalized Compact Channel-Boosted High-Order Orderless Pooling Network

Remote Sensing, 2019
The convolutional neural network (CNN) has achieved great success in the field of scene classification. Nevertheless, strong spatial information in CNN and irregular repetitive patterns in synthetic aperture radar (SAR) images make the feature ...
Kang Ni, Yiquan Wu, Peng Wang
doaj   +1 more source

Targeting c-Jun in A549 Cancer Cells Exhibits Antiangiogenic Activity In Vitro and In Vivo Through Exosome/miRNA-494-3p/PTEN Signal Pathway

Frontiers in Oncology, 2021
The oncogene c-Jun is activated by Jun N-terminal kinase (JNK). Exosomes are nanometer-sized membrane vesicles released from a variety of cell types, and are essential for cell-to-cell communication.
Chen Shao, Yingying Huang, Bingjie Fu, Shunli Pan, Xiaoxia Zhao, Ning Zhang, Wei Wang, Zhe Zhang, Yuling Qiu, Ran Wang, Meihua Jin, Dexin Kong, Dexin Kong   +12 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

An Improved Column Generation Algorithm Based on Minimum-Norm Multipliers

Mathematics
Column generation is a fundamental technique for solving large-scale combinatorial optimization problems such as unit commitment and vehicle routing, yet its performance is often limited by dual oscillation.
Dingfang Su, Jie Tao, Jiaxu Huang, Erzhan Gao   +3 more
doaj   +1 more source