Results 31 to 40 of about 1,657,853 (308)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Rapid detection of carbapenem-resistant Escherichia coli and carbapenem-resistant Klebsiella pneumoniae in positive blood cultures via MALDI-TOF MS and tree-based machine learning models

BMC Microbiology
Background Bloodstream infection (BSI) is a systemic infection that predisposes individuals to sepsis and multiple organ dysfunction syndrome. Early identification of infectious agents and determination of drug-resistant phenotypes can help patients with
Xiaobo Xu, Zhaofeng Wang, Erjie Lu, Tao Lin, Hengchao Du, Zhongfei Li, Jiahong Ma   +6 more
doaj   +1 more source

Prevalence, antibiotic resistance and molecular characterization of Staphylococcus aureus in ready-to-eat fruits and vegetables in Shanghai, China

Current Research in Food Science
Staphylococcus aureus (S. aureus) is one of the foodborne pathogens. This study aimed to investigate the prevalence of S. aureus in ready-to-eat (RTE) fruits and vegetables in Shanghai, China.
Kai Jia, Xiaojie Qin, Xiangfeng Bu, Huajian Zhu, Yangtai Liu, Xiang Wang, Zhuosi Li, Qingli Dong   +7 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Distribution of gut microbiota and prognostic value in elderly patients with coronary atherosclerosis: a preliminary culture-based study

BMC Cardiovascular Disorders
Objective This study aimed to characterize the distribution of specific cultivable gut microbiota in elderly patients with coronary artery disease (CAD) and evaluate their prognostic significance. Methods A cohort of 200 elderly CAD patients, categorized
Hengchao Du, Xiaobo Xu, Qunyan Lei, Chengsi Qian, Zhaofeng Wang, Xinyan Yu, Qunfang Lei   +6 more
doaj   +1 more source

Scene Classification from Synthetic Aperture Radar Images Using Generalized Compact Channel-Boosted High-Order Orderless Pooling Network

Remote Sensing, 2019
The convolutional neural network (CNN) has achieved great success in the field of scene classification. Nevertheless, strong spatial information in CNN and irregular repetitive patterns in synthetic aperture radar (SAR) images make the feature ...
Kang Ni, Yiquan Wu, Peng Wang
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Tunable-Charge Optical Vortices Through Edge Diffraction of a High-Order Hermit-Gaussian Mode Laser

Photonics
An optical vortex is a typical structured light field characterized by a helical wavefront and a central phase singularity. With its expanding applications in modern information technology, the demand for generating vortex beams with diverse topological ...
Shuaichen Li, Yiyang Zhang, Ying Li, Linge Mao, Pengfan Zhao, Zhen Qiao   +5 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

An Improved Column Generation Algorithm Based on Minimum-Norm Multipliers

Mathematics
Column generation is a fundamental technique for solving large-scale combinatorial optimization problems such as unit commitment and vehicle routing, yet its performance is often limited by dual oscillation.
Dingfang Su, Jie Tao, Jiaxu Huang, Erzhan Gao   +3 more
doaj   +1 more source