Results 51 to 60 of about 3,727,812 (304)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

jan./jun. 2021

Tomo, 2020
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Expediente Expediente
doaj   +1 more source

Stimulation of c-Jun/AP-1-Activity by the Cell Cycle Inhibitor p57Kip2

Frontiers in Cell and Developmental Biology, 2021
p57 is a member of the Cip/Kip family of cell cycle inhibitors which restrict the eukaryotic cell cycle by binding to and inhibiting cyclin/CDK complexes.
Michael Keith Kullmann, Fragka Pegka, Christian Ploner, Ludger Hengst   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Exploring collaborative practice between conventional and Korean medicine: a qualitative study of Korean medicine doctors’ experienced barriers and strategies

BMC Complementary Medicine and Therapies
Background In South Korea, collaborative practice between conventional medicine (CM) and traditional Korean medicine (CPCK) is expanding under consumer demand and supportive national policies in line with global trend.
Dasol Park, Moon Joo Cheong, Hyungsun Jun, Jungah Uhm, Inae Youn, Jungtae Leem   +5 more
doaj   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Color Superconductivity: Symmetries and Effective Lagrangians

, 2001
I briefly review the symmetries and the associated low energy effective Lagrangian for two light flavor Color Superconductivity (2SC).Comment: 6 pages, AIP format.
Sannino, Francesco
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

The Proximal Alternating Direction Method of Multipliers for a Class of Nonlinear Constrained Optimization Problems

Mathematics
This paper presents a class of proximal alternating direction multiplier methods for solving nonconvex, nonsmooth optimization problems with nonlinear coupled constraints.
Ruiling Luo, Zhensheng Yu
doaj   +1 more source

Prognostic and clinicopathological significance of transcription factor c-Jun in hypopharyngeal squamous cell carcinoma: a 3-year follow-up retrospective study

BMC Cancer, 2022
Purpose To investigate the expression and prognostic value of c-Jun in hypopharyngeal squamous cell carcinoma (HPSCC). Methods A retrospective study was performed on a cohort of 99 HPSCC patients. The expression of c-Jun and phosphorylated-c-Jun (p-c-Jun)
Qiang Huang, Min Ye, Feiran Li, Lan Lin, Chunyan Hu   +4 more
doaj   +1 more source