Results 31 to 40 of about 7,154 (238)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Association of junk food consumption with overweight-obesity among preclinical medical students of Shahid Beheshti University of Medical Sciences

Social Determinants of Health, 2019
Background: The consumption of high energy and low nutritional content foods, which are known as junk foods, is considered as one of the main causes of obesity particularly in adolescents.
Mohammad Masih Mansouri-Tehrani, Seyedreza Hashemi-rad, Tiam Hajiha, Seyedalisina Mousavian, Arezoo Rezazadeh   +4 more
doaj   +1 more source

The differential effect of maternal dietary patterns on quantiles of Birthweight

BMC Public Health, 2020
Background Maternal dietary habits during pregnancy are considered essential for development and growth of the fetus as well as maternal health. It has an effect on the birthweight of infants. However, little is known about the effect of dietary patterns
Aweke A. Mitku, Temesgen Zewotir, Delia North, Prakash Jeena, Rajen N. Naidoo   +4 more
doaj   +1 more source

Psychosocial correlates in patterns of adolescent emotional eating and dietary consumption.

PLoS ONE, 2023
Unhealthy eating behaviors, such as consumption of unhealthy diet and emotional eating, are common in adolescence and tend to co-occur. However, how these behaviors are patterned may vary among adolescents.
Patrece L Joseph, Carolina Gonçalves, Sasha A Fleary   +2 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Junk Food Consumption among High School Students in Iran: The Role of Food Advertising

Journal of Holistic Nursing and Midwifery, 2020
Introduction: Adolescence is one of the most important periods of human development. Nutrition plays an important role in health and prevention of disease during this period.
Saeid Moradi Latreyi, Leila Mirhadyan, Afsaneh Pasha, Ehsan Kazemnezhad Leili   +3 more
doaj  

REVIEW ARTICLE: Fast Foods and their Impact on Health [PDF]

Journal of Krishna Institute of Medical Sciences University, 2012
Eat healthy and live healthy’ is one of the essential requirements for long life. Unfortunately, today’s world has been adapted to a system of consumption of foods which has several adverse effects on health.
Ashakiran, Deepthi R
doaj  

Junk Food Exposure Disrupts Selection of Food-Seeking Actions in Rats

Frontiers in Psychiatry, 2018
There is growing evidence that repeated consumption of highly palatable, nutritionally poor “junk food” diets can produce deficits in cognition and behavioral control.
Alisa R. Kosheleff, Jingwen Araki, Linda Tsan, Grace Chen, Niall P. Murphy, Nigel T. Maidment, Sean B. Ostlund, Sean B. Ostlund   +7 more
doaj   +1 more source

Junk Food in Schools and Childhood Obesity [PDF]

Journal of Policy Analysis and Management, 2012
AbstractDespite limited empirical evidence, there is growing concern that junk food availability in schools has contributed to the childhood obesity epidemic. In this paper, we estimate the effects of junk food availability on body mass index (BMI), obesity, and related outcomes among a national sample of fifth graders.
Ashlesha, Datar, Nancy, Nicosia
openaire   +2 more sources