Results 91 to 100 of about 43,474 (209)

Exogenous tetracosahexaenoic acid modifies the fatty acid composition of human primary T lymphocytes and Jurkat T cell leukemia cells contingent on cell type. [PDF]

Lipids, 2023
Irvine NA, West AL, Von Gerichten J, Miles EA, Lillycrop KA, Calder PC, Fielding BA, Burdge GC.   +7 more
europepmc   +1 more source

Detection and Inhalation Hazard Assessment of Wear Particles Arising From Abrasion of Market‐relevant Graphene Reinforced Composites

Small, EarlyView.
Abrasion of few‐layer graphene (FLG)–epoxy composites generated respirable particles in which FLG remained fully embedded, as confirmed by correlative HR‑TEM, Raman, and ToF‑SIMS analyses. Advanced lung cell models revealed no cytotoxic or inflammatory responses, and only high‑dose epoxy particles reduced mucociliary clearance.
Govind Gupta, Jimmy Vernaz, Antje Vennemann, Maike Stange, Asmus Meyer‐Plath, Servane Contal, Sarah Zehnder, Ziting Wang, Aline Chary, Stephanie Eitner, Philipp Mueller, Vera M. Kissling, Samuel Constant, Lucie Chupin, Daniel Breitenstein, Birgit Hagenhoff, Tommaso Serchi, Bernadett Boda, Martin Wiemann, Peter Wick, Tina Buerki‐Thurnherr   +20 more
wiley   +1 more source

Self-Assembled Nanoparticles Prepared from Low-Molecular-Weight PEI and Low-Generation PAMAM for EGFRvIII-Chimeric Antigen Receptor Gene Loading and T-Cell Transient Modification

International Journal of Nanomedicine, 2020
Qianru Yu,1,* Maxin Zhang,1,* Yuetan Chen,1,* Xiaolong Chen,2 Sanyuan Shi,1 Kang Sun,1 Ran Ye,1 Yuan Zheng,1 Yang Chen,1 Yuhong Xu,1,3 Jinliang Peng1 1School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, People’s Republic of China ...
Yu Q, Zhang M, Chen Y, Chen X, Shi S, Sun K, Ye R, Zheng Y, Chen Y, Xu Y, Peng J   +10 more
doaj  

Naegleria fowleri Induces Jurkat T Cell Death via O-deGlcNAcylation. [PDF]

Korean J Parasitol, 2021
Lee YA, Kim KA, Shin MH.
europepmc   +1 more source

Cytotoxic effect of potato aspartic proteases (StAPs) on Jurkat T cells

Fitoterapia, 2010
StAPs are potato aspartic proteases with cytotoxic activity against plant pathogens and spermatozoa. StAPs cytotoxic activity is selective, since these proteins do not exert toxic effect on plant cells and erythrocytes. In this work, we investigated the capacity of StAPs to exert cytotoxicity on human leukaemia cells.
MENDIETA J. R., FIMOGNARI, CARMELA, G. R. DALEO, HRELIA, PATRIZIA, M. G. GUEVARA   +4 more
openaire   +4 more sources

Design, synthesis and activity evaluation of tetrahydroisoquinoline‐based programmed cell death ligand 1 inhibitors

Smart Molecules, EarlyView.
Based on a 3D‐quantitative structure‐activity relationship pharmacophore model, structural optimization of Y6 yielded Y7f. Mechanistic studies revealed that Y7f acted as a programmed death receptor 1/programmed cell death ligand 1 (PD‐L1) interaction inhibitor by inducing PD‐L1 dimerization. Y7f restored T‐cell function.
Menglin Yu, Sen Cai, Yanyan Pan, Heshuang Wang, Fengwu Zhang, Aiyu Ma, Shixuan Lv, Xiuhan Guo, Shisheng Wang, Qiling Song, Chunyan Ma, Shuai Wang, Li Zhang, Jian Wang, Qingwei Meng, Yueqing Li   +15 more
wiley   +1 more source

HIV-1 tat expression and sulphamethoxazole hydroxylamine mediated oxidative stress alter the disulfide proteome in Jurkat T cells

Virology Journal, 2018
Background Adverse drug reactions (ADRs) are a significant problem for HIV patients, with the risk of developing ADRs increasing as the infection progresses to AIDS. However, the pathophysiology underlying ADRs remains unknown.
Kemi Adeyanju, John R. Bend, Michael J. Rieder, Gregory A. Dekaban   +3 more
doaj   +1 more source

S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca²⁺ signaling by Jurkat T cell receptors at the immune synapse. [PDF]

Elife, 2021
Carreras-Sureda A, Abrami L, Ji-Hee K, Wang WA, Henry C, Frieden M, Didier M, van der Goot FG, Demaurex N.   +8 more
europepmc   +1 more source

Microfluidic Molecular Diagnostic Chips: Functional Modules, Integration Strategies, and Emerging Applications

Small Methods, EarlyView.
This comprehensive review delivers an engineering‐centric analysis of microfluidic molecular diagnostic chips, breaking them down into foundational modules from fluid manipulation to bio‐sensing. Beyond chip design, it evaluates sample‐to‐answer integration strategies and commercial readiness levels.
Donghoon Koo, Egor Kokin, Sangyul Baik, Chanyong Park, Minji Kim, Jeongmin Kim, Ryungeun Song, Hosub Lim   +7 more
wiley   +1 more source

Development of chimeric antigen receptors targeting T-cell malignancies using two structurally different anti-CD5 antigen binding domains in NK and CRISPR-edited T cell lines

OncoImmunology, 2018
Relapsed T-cell malignancies have poor outcomes when treated with chemotherapy, but survival after allogeneic bone marrow transplantation (BMT) approaches 50%. A limitation to BMT is the difficulty of achieving remission prior to transplant.
Sunil S. Raikar, Lauren C. Fleischer, Robert Moot, Andrew Fedanov, Na Yoon Paik, Kristopher A. Knight, Christopher B. Doering, H. Trent Spencer   +7 more
doaj   +1 more source