Results 1 to 10 of about 62,486 (251)
A genome-wide survey of mutations in the Jurkat cell line [PDF]
BMC Genomics, 2018 Background The Jurkat cell line has an extensive history as a model of T cell signaling. But at the turn of the 21st century, some expression irregularities were observed, raising doubts about how closely the cell line paralleled normal human T cells ...
Louis Gioia +4 more
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Wellcome Open Research, 2021 Background: The leukaemia-derived Jurkat E6.1 cell line has been used as a model T cell in the study of many aspects of T cell biology, most notably activation in response to T cell receptor (TCR) engagement.
Suet Ling Felce +3 more
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Exosomes are unlikely involved in intercellular Nef transfer. [PDF]
PLoS ONE, 2015 HIV-1 Nef is an important pathogenic factor for HIV/AIDS pathogenesis. Several recent studies including ours have demonstrated that Nef can be transferred to neighboring cells and alters the function of these cells.
Xiaoyu Luo +3 more
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Calcium enhances polyplex-mediated transfection efficiency of plasmid DNA in Jurkat cells
Drug Delivery, 2020 Jurkat, an immortalized cell line derived from human leukemic T lymphocytes, has been employed as an excellent surrogate model of human primary T-cells for the advancement of T-cell biology and their applications in medicine.
V. S. S. Abhinav Ayyadevara +1 more
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Significance of nutrient media choice for the long-term cultures of leukemic T-lymphoblasts
Медицинская иммунология, 2021 Correct choice of nutrient media for culturing different types of cells in various applications is one of the most important aspects of modern biotechnology, since chemical composition of the culture media largely contains the necessary metabolites to ...
L. S. Litvinova +10 more
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Protective effects of pentoxifylline on T-cell viability under inflammatory conditions
European Journal of Inflammation, 2022 Introduction: Pentoxifylline (PTX) reduces the levels of pro-inflammatory cytokines; however, its effects on immune system is not well understood. The aim of this study was to investigate the effect of PTX on T cells under inflammatory conditions in co ...
Sung-Joon Park +6 more
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Journal of Experimental & Clinical Cancer Research, 2011 Objective To explore the potential role of CpG motif-containing oligonucleotides (CpG-ODN) in modulating the expression of FasL in HepG2 and Fas in Jurkat cells in vitro, and to examine the effect of CpG-ODN treatment on the HepG2 cells-mediated Jurkat ...
Li Jing +3 more
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Dual Effects of Resveratrol on the Expression and Secretion of Angiogenic Factors [PDF]
International Journal of Molecular and Cellular Medicine, 2022 Angiogenesis is an essential process in the growth, development and transition of tumors from dormancy to proliferating state. Resveratrol (RSV), as a natural polyphenolic compound, is claimed to be effective in angiogenesis regulation.
Pegah Kiyamehr +3 more
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Journal of Hematology & Oncology, 2018 Background Despite the high cure rate of T cell acute lymphoblastic leukemia (T-ALL), drug resistance to chemotherapy remains a significant clinical problem.
Jiancheng Wang +15 more
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Induction of cell death and modulation of Annexin A1 by phytoestrogens in human leukemic cell lines
Saudi Pharmaceutical Journal, 2021 Background: Phytoestrogens are polyphenolic plant compounds which are structurally similar to the endogenous mammalian estrogen, 17β-estradiol. Annexin A1 (ANXA1) is an endogenous protein which inhibits cyclo-oxygenase 2 (COX-2) and phospholipase A2 ...
Affidah Sabran +5 more
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