Results 41 to 50 of about 62,486 (251)

Modulation of inflammatory and adrenergic pathways in hypertension: effects of β-blockers on cytokine release in Jurkat T cells

Acta Biochimica Polonica
Research aimed to examine the effects of β-blockers on cytokine release in Jurkat cells under basal conditions and during oxidative stress. Oxidative stress was induced in Jurkat cells through the application of hydrogen peroxide (H2O2).
Nana Kajaia, Maia Enukidze, Marine Machavariani, Tinatin Maminaishvili, Tinatin Maminaishvili, Sophio Kalmakhelidze, George Ormotsadze, Tamar Sanikidze, Tamar Sanikidze   +8 more
doaj   +1 more source

Shutdown of HIV-1 Transcription in T Cells by Nullbasic, a Mutant Tat Protein

mBio, 2016
Nullbasic is a derivative of the HIV-1 transactivator of transcription (Tat) protein that strongly inhibits HIV-1 replication in lymphocytes. Here we show that lentiviral vectors that constitutively express a Nullbasic-ZsGreen1 (NB-ZSG1) fusion protein ...
Hongping Jin, Dongsheng Li, Haran Sivakumaran, Mary Lor, Lina Rustanti, Nicole Cloonan, Shivangi Wani, David Harrich   +7 more
doaj   +1 more source

Anticancer Activity of Lesbicoumestan in Jurkat Cells via Inhibition of Oxidative Stress-Mediated Apoptosis and MALT1 Protease

Molecules, 2021
This study explores the potential anticancer effects of lesbicoumestan from Lespedeza bicolor against human leukemia cancer cells. Flow cytometry and fluorescence microscopy were used to investigate antiproliferative effects.
Joo-Eun Lee, Fang Bo, Nguyen Thi Thanh Thuy, Jaewoo Hong, Ji Shin Lee, Namki Cho, Hee Min Yoo   +6 more
doaj   +1 more source

Biomass DNA: An Emerging Building Block for Advanced Materials

Advanced Materials, EarlyView.
Biomass DNA is rapidly emerging from its traditional role as a genetic blueprint to serve as a versatile abundant, highly programmable polymeric building block. This review highlights the transformation of macroscopic bulk biomass DNA into next generation of functional materials, spanning from dynamic hydrogels, sustainable bioplastics, and high ...
Yuwei Hu, Itamar Willner, Li Niu
wiley   +1 more source

Antiproliferative and proapoptotic effects of a pyrrole containing arylthioindole in human Jurkat leukemia cell line and multidrug-resistant Jurkat/A4 cells [PDF]

Cancer Biology & Therapy, 2015
Recently, a series of novel arylthioindole compounds, potent inhibitors of tubulin polymerization and cancer cell growth, were synthesized. In the present study the effects of 2-(1H-pyrrol-3-yl)-3-((3,4,5-trimethoxyphenyl)thio)-1H-indole (ATI5 compound) on cell proliferation, cell cycle progression, and induction of apoptosis in human T-cell acute ...
Philchenkov, Alex A., Zavelevich, Michael P., Tryndyak, Volodymyr P., Kuiava, Ludmila M., Blokhin, Dmitry Yu, Miura, Koh, SILVESTRI, Romano, Pogribny, Igor P.   +7 more
openaire   +2 more sources

Action of inhibitors Heat shock proteins 90 and 27 on dexamethasone-induced apoptosis of tumor cells

Бюллетень сибирской медицины, 2010
Programmed cell death of tumor cells of line Jurkat in conditions of cultivation with various concentration of dexamethasone, selective inhibitors of Hsp90 (Heat shock protein — Hsp) (17-AAG) and Hsp27 (KRIBB3) was investigated.
Ye. V. Kaigorodova, N. V. Ryazantseva, V. V. Novitsky, A. N. Maroshkina, M. V. Belkina, O. Ye. Chechina, A. P. Zima   +6 more
doaj   +1 more source

Effect of SATB1 expression on replication timing at TTR: suppression of SATB1 expression in Jurkat cells.

, 2012
A. The procedure for repression of SATB1 expression in Jurkat. B. Whole cell extracts were examined by western blotting using anti-SATB1 antibody. Lane 1, untransfected Jurkat; lane 2, Jurkat transfected with pRS vector; lane 3 and 4, Jurkat transfected ...
Hisao Masai (59105), Yoshihisa Watanabe (105832), Masako Oda (145964), Yutaka Kanoh (145965)   +3 more
core   +1 more source

Dual‐Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti‐Inflammatory and Anti‐Fibrotic Effects

Advanced Science, EarlyView.
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang, Jinwei Li, Shan Hua, Shengming Wu, Chenlong He, Yuan Zhu, Ming Yin, Han Zhou, Huawei Liu, Chika Hasegawa, Jun Lyu, Keyue Xiao, Hua Jiang, Yilong Wang, Yuxin Qian   +14 more
wiley   +1 more source

Ubiquitin and regulation of apoptosis in Jurkat cells

Bulletin of Siberian Medicine, 2018
Introduction.One of the crucial tasks in medicine is studying the molecular mechanisms of selective management of tumor cell apoptosis following conformational changes in protein molecules (ubiquitination).The purpose of the study. The aim of the project is to establish the role of ubiquitin and ubiquitinligase in dexamethasone-induced apoptosis in ...
O. L. Nosareva, E. A. Stepovaya, N. V. Ryazantseva, E. V. Shakhristova, D. S. Orlov, V. V. Novitsky   +5 more
openaire   +3 more sources

Involvement of calpain in the process of Jurkat T cell chemotaxis [PDF]

Journal of Neuroscience Research, 2008
AbstractMassive T cell infiltration into the central nervous system is a hallmark of multiple sclerosis (MS) and its rodent model experimental autoimmune encephalomyelitis (EAE), resulting in the induction of many of the pathophysiological events that lead to neuroinflammation and neurodegeneration.
Jonathan T, Butler, Supriti, Samantaray, Craig C, Beeson, Swapan K, Ray, Naren L, Banik   +4 more
openaire   +2 more sources