Results 11 to 20 of about 62,486 (251)

Opium Induces Apoptosis in Jurkat Cells [PDF]

Addiction and Health, 2013
Background: The direct effect of some opioids on immune cells has been demonstrated. The aim of this study was to assess the apoptotic effect of opium on Jurkat T lymphocyte cells. Methods: Different concentrations of opium (2.86 × 10-3 to 2.86 × 10-11 g/
Somayeh Igder, Gholam-Reza Asadikaram, Farzaneh Sheykholeslam, Ahmad-Reza Sayadi, Mehdi Mahmoodi, Mohammad Kazemi Arababadi, Mohammad Javad Rasaee   +6 more
doaj   +4 more sources

Morphine promotes apoptosis in Jurkat cells [PDF]

Journal of Leukocyte Biology, 1999
Abstract Patients with intravenous heroin addiction are prone to recurrent infections and at times these infections are fatal. We evaluated the effect of morphine on the apoptosis of Jurkat cells and freshly isolated human T lymphocytes. Morphine promoted apoptosis of both the Jurkat cells and the freshly isolated T lymphocytes in a dose-
P C, Singhal, A A, Kapasi, K, Reddy, N, Franki, N, Gibbons, G, Ding   +5 more
openaire   +3 more sources

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription. [PDF]

FEBS Open Bio
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Wang L, Deng M, He D, Lai D, Liu D, Zhu D, Zhang Z, Tang P, Zhou C, Yin M, Bao X.   +10 more
europepmc   +2 more sources

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo. [PDF]

Adv Sci (Weinh)
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Li M, Lyu J, Li K, Dravid A, Balasubramani D, K Ashkezari AH, Choi HK, Kwong GA, Singh A, Zhu C.   +9 more
europepmc   +2 more sources

Detaching Photosensitive Nanoparticles from Cells Prevents Them from Remaining in Cells after Photoporation. [PDF]

Adv Sci (Weinh)
Phenylboronic acid‐functionalized gold nanoparticles reversibly attach to cell‐surface glycans, enhancing photoporation‐mediated intracellular delivery. After irradiation, ATP competitively disrupts the boronic ester interactions and removes cell‐associated nanoparticles, markedly reducing residual gold.
Lu T, Nikolić M, Huang B, Punj D, De Keersmaecker H, Van Acker T, Xie W, Vanlauwe F, Blondeel P, De Graeve L, Sauvage F, Xiong R, Huang C, Vanhaecke F, Braeckmans K, De Smedt SC.   +15 more
europepmc   +2 more sources

Recruitment of dynein to the Jurkat immunological synapse [PDF]

Proceedings of the National Academy of Sciences, 2006
Binding of T cells to antigen-presenting cells leads to the formation of the immunological synapse, translocation of the microtubule-organizing center (MTOC) to the synapse, and focused secretion of effector molecules. Here, we show that upon activation of Jurkat cells microtubules project from the MTOC to a ring of the scaffolding protein ADAP ...
Jeffrey, Combs, Soo Jin, Kim, Sarah, Tan, Lee A, Ligon, Erika L F, Holzbaur, Jeffrey, Kuhn, Martin, Poenie   +6 more
openaire   +2 more sources

Modification of carboplatin by Jurkat cells

Journal of Inorganic Biochemistry, 2007
Using [(1)H,(15)N] heteronuclear single quantum coherance (HSQC) NMR and (15)N-labeled carboplatin, 1, we show that Jurkat cells affect the rate of disappearance of the HSQC NMR peak in culture medium for this Pt(2+) anticancer drug. The decay or disappearance rate constant for 1 in culture medium containing cells is k(1)=k(c)[CO(3)(2-)]+k(m)+k(u)N ...
Di Pasqua, Anthony J, Goodisman, Jerry, Kerwood, Deborah J., Dabrowiak, James C, Toms, Bonnie B   +4 more
openaire   +3 more sources

Identifikation der Wirkfaktoren und qualitative Evaluation des Praxiskurses „Stressbewältigung im Medizinstudium“ [PDF]

, 2020
Hintergrund: Im Zeitraum von 2008 bis 2019 wurde unter der Leitung von PD Dr. Jurkat am Fachbereich Medizin der JLU Gießen der durch dezentrale QSL-Mittel geförderte Praxiskurs „Stressbewältigung im Medizinstudium“ durchgeführt, welcher auf umfangreichen,
Steinbrecher, Katharina
core   +1 more source

Intracellular Ca2+ pools in Jurkat T-lymphocytes [PDF]

Biochemical Journal, 1993
Jurkat T-lymphocytes comprise at least four intracellular Ca2+ pools. Pool I was agonist-sensitive and contained 23 +/- 8% (n = 18) of the total Ca(2+)-storage capacity, as shown in intact cells in the presence of EGTA. The time courses of the agonist-induced formation of Ins(1,4,5)P3 and of the Ca2+ release from pool I were nearly superimposable ...
A H, Guse, E, Roth, F, Emmrich
openaire   +2 more sources

BITE-Jurkat Assay using direct electroporation in Jurkats.

, 2023
(A) Human Jurkat T cells were electroporated with CD19-targeted BITE or CAR plasmids as described in the methods section. Following recovery, electroporated Jurkat cells were then placed in co-culture with fluorescently labelled CD19-expressing target ...
Risini D. Weeratna (5771144), Darin Bloemberg (171157), Alex Shepherd (13135911), Robert A. Pon (13135923), Anne Marcil (275083), Bigitha Bennychen (16425868), Scott McComb (234597)   +6 more
core   +1 more source