Results 51 to 60 of about 274,200 (260)
Digital mental health care: five lessons from Act 1 and a preview of Acts 2–5
npj Digital Medicine, 2023 Digital tools are transforming mental health care. The promise of this transformation to improve outcomes has not yet been realized fully. While some have become skeptical, this article argues that we are just at the end of Act 1, with several ...
Thomas Insel
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
A framework for researching African food systems
Frontiers in Sustainable Food SystemsThe structure and functioning of current African food systems, together with unfavourable terms of trade and climate change impacts, pose significant challenges to achieving sustainability and more equitable outcomes.
Julian May +5 more
doaj +1 more source
DIGITAL TRANSFORMATION IN ROMANIA [PDF]
Fiabilitate şi Durabilitate, 2019 Digital transformation means bringing together people, data and processes. A digital transformation strategy that focuses on these three pillars will help us create value for our customers and maintain our competitive edge in a digitized world ...
Ştefan IOVAN, Ramona MARGE
doaj
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Unprecedented strength in pure iron via high-pressure induced nanotwinned martensite
Materials Research Letters, 2019 Martensitic transformation can easily induce a maximum hardness value of 800–900 HV (Vickers hardness) for steels with carbon contents of 0.6 wt.% and above.
Hongwang Zhang +7 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Earth's FutureHumans are now operating well outside the planetary conditions under which social and economic development has been possible. A precondition for securing equitable access to this prosperity is to safeguard the stability of the Earth system. The situation
Johan Rockström +52 more
doaj +1 more source