Results 61 to 70 of about 296,412 (302)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Transformation of traditional manufacturers towards servitized organisations [PDF]
, 2012 In response to competitive and economic pressures, an increasing number of manufacturing firms are adding services to their traditional product offerings.
Vladimirova, Doroteya Kamenova
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Digital mental health care: five lessons from Act 1 and a preview of Acts 2–5
npj Digital Medicine, 2023 Digital tools are transforming mental health care. The promise of this transformation to improve outcomes has not yet been realized fully. While some have become skeptical, this article argues that we are just at the end of Act 1, with several ...
Thomas Insel
doaj +1 more source
, 2022 The following report presents and illustrates a design proposal for a socially and environmentally sustainable transformation of the existing buildings at Frederiksberg Hospital - from hospital to a new open and welcoming neighborhood.
Dall, Lis +2 more
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A framework for researching African food systems
Frontiers in Sustainable Food SystemsThe structure and functioning of current African food systems, together with unfavourable terms of trade and climate change impacts, pose significant challenges to achieving sustainability and more equitable outcomes.
Julian May +5 more
doaj +1 more source
DIGITAL TRANSFORMATION IN ROMANIA [PDF]
Fiabilitate şi Durabilitate, 2019 Digital transformation means bringing together people, data and processes. A digital transformation strategy that focuses on these three pillars will help us create value for our customers and maintain our competitive edge in a digitized world ...
Ştefan IOVAN, Ramona MARGE
doaj
Environmental Research Letters, 2022 China’s power sector, as the major CO _2 emitter, has experienced significant restructuring that has had profound impacts on employment in both power and its upstream sectors.
Sili Zhou +6 more
doaj +1 more source
What role for CCS in delivering just transitions? An evaluation in the North Sea region. [PDF]
, 2020 This paper assesses the role of carbon dioxide capture and storage (CCS) in addressing challenges in the energy transition, in regions reliant on carbon-intensive industries for employment and as an economic base.
Flach, T.A. +6 more
core +1 more source