Results 71 to 80 of about 296,412 (302)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Unprecedented strength in pure iron via high-pressure induced nanotwinned martensite

Materials Research Letters, 2019
Martensitic transformation can easily induce a maximum hardness value of 800–900 HV (Vickers hardness) for steels with carbon contents of 0.6 wt.% and above.
Hongwang Zhang, Yuhui Wang, Yan Peng, Pinwen Zhu, Jianhua Liu, Zongqiang Feng, Guilin Wu, Xiaoxu Huang   +7 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Charting a Transformational Course Toward a Safe and Just Future: The Earth Commission's Contribution

Earth's Future
Humans are now operating well outside the planetary conditions under which social and economic development has been possible. A precondition for securing equitable access to this prosperity is to safeguard the stability of the Earth system. The situation
Johan Rockström, Fatima Denton, Albert V. Norström, Jesse F. Abrams, Lubna Alam, David I. Armstrong McKay, Xuemei Bai, Govindasamy Bala, Chris Boulton, Wendy J. Broadgate, Stuart E. Bunn, Joshua E. Buxton, Juan Camilo Cárdenas, Raimon C. Ylla‐Català, Fabrice DeClerck, Natalie Davis, Donovan P. Dennis, Miriam L. Diamond, Carl Folke, Charlotte Kendra Gotangco Gonzales, Georgia Graells, Joyeeta Gupta, Syezlin Hasan, Lisa Jacobson, Steven J. Lade, Timothy M. Lenton, Sina Loriani, Cornelia Ludwig, Pablo A. Marquet, Qondi Moyo, Aditi Mukherji, Nebojsa Nakicenovic, David Obura, Taikan Oki, Daniel Ospina, Maria Fernanda Peña, Laura Pereira, Alexander Popp, Keywan Riahi, Maria del Mar Rojas, Anindita Sarkar, Anna Shalin, Ben Stewart‐Koster, Bo Su, Rashid Sumaila, Thejna Tharammal, Luc vanVliet, Detlef vanVuuren, Peter Verburg, Zhanyun Wang, Ricarda Winkelmann, Cunde Xiao, Caroline Zimm   +52 more
doaj   +1 more source

Adaptation policy and community discourse : risk, vulnerability, and just transformation [PDF]

, 2017
How can public engagement assist in the development of just processes and outcomes in adaptation discourse and policymaking? A concern with justice is at the center of thinking about adaptation that is not only resilient, but also public, engaging, and ...
Niemeyer, Simon, Collins, Lisette B.,, Lisette B. Collins, David Schlosberg, Niemeyer, Simon,, Collins, Lisette B., Simon Niemeyer, Schlosberg, David,, Schlosberg, David, Niemeyer, Simon; id_orcid   +9 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

DERIVATION OF THE LORENTZ-EINSTEIN TRANSFORMATION VIA ONE OBSERVER

Journal of Engineering, 2010
Lorentz-Einstein transformation derived by Einstein in his theory of special relativity. Physical laws and principles are invariant in all Galilean reference frames under this transformation.
O.M. AL-Kazalchi, Faiz T. Omara
doaj   +1 more source