Results 71 to 80 of about 391,277 (261)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Energy transition: Connotations, mechanisms and effects

Energy Strategy Reviews
Currently, the research agenda of energy transition is gaining momentum. This paper conducts a comprehensive review of this body of research by presenting a framework that describes the connotations, mechanisms, and effects of energy transitions.
Yu Yang, Siyou Xia, Ping Huang, Junxi Qian   +3 more
doaj   +1 more source

Just transition in the northwest territories: Insights and values from indigenous and non-indigenous northerners. [PDF]

Heliyon, 2023
Amber C, Agrawal S, Zoe C.
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

How do past global experiences of coal phase-out inform China's domestic approach to a just transition? [PDF]

Sustain Sci, 2023
Sharma V, Loginova J, Zhang R, Kemp D, Shi G.   +4 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Just Transitions in a Public School Food System: The Case of Buffalo, New York

Journal of Agriculture, Food Systems, and Community Development, 2018
This article examines the public school food system in Buffalo, New York, for a just transition (Movement Generation, n. d.). School food programs built on just transition characteristics democratize engagement, decentralize decision-making, diversify ...
Jessica L. Gilbert, Alexandra E. Schindel, Sarah A. Robert   +2 more
doaj   +1 more source

Sustainability after COVID-19: pillars for a just transition. [PDF]

Environ Sustain (Singap), 2022
Morrissey J, Heidkamp P.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Just Transition on air quality governance: a case study of heavy-duty diesel truck protests in Taiwan. [PDF]

Sustain Sci, 2023
Walther D, Chou KT.
europepmc   +1 more source