Results 71 to 80 of about 2,720,288 (295)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Institutional determinants of investment in transition economies [PDF]

open access: yes, 2009
Investment has been found to be a significant determinant of growth. This paper analyses the effects of institutions and transition progress on investment rates of transition economies since the collapse of the Socialist Bloc. Political institution is
Dang, V
core  

Rules for transition rates in nonequilibrium steady states

open access: yes, 2004
Just as transition rates in a canonical ensemble must respect the principle of detailed balance, constraints exist on transition rates in driven steady states.
C. E. Shannon   +7 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Motion for a "Just Transition" in Response to Closure of the Mohave Generating Station [PDF]

open access: yes, 2006
Mohave Generating Station closed on December 31, 2005. The Grand Canyon Trust organized an innovative proposal to the California Public Utility Commission to direct the use of revenues from the sale of Mohave's sulfur credits to benefit tribal ...
Sara Steck Myers
core  

A Configurationally-Resolved-Super-Transition-Arrays method for calculation of the spectral absorption coefficient in hot plasmas

open access: yes, 2012
A new method, 'Configurationally-Resolved-Super-Transition-Arrays', for calculation of the spectral absorption coefficient in hot plasmas is presented. In the new method, the spectrum of each Super-Transition-Array is evaluated as the Fourier transform ...
Bar Shalom   +33 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Aspects of Gender Vulnerability in the Just Transition Process [PDF]

open access: yesOvidius University Annals: Economic Sciences Series, 2023
The just transition targets aspects with a strong social impact that influence the quality of life of communities on the front line of the energy transition. These communities are found in coal-bearing and heavily industrialized areas.
Diana Joita, Doru Claudiu Damean
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Une transition planétaire juste ? Comment la rendre inclusive et juste ?

open access: yesDéveloppement Durable et Territoires
Planetary justice (pj) requires a profound planetary just transition (pjt). Recognizing the essentially contested nature of just transition (jt) we propose an analytical scheme to better interpret and differentiate amongst the growing number of jt ...
Dimitris Stevis, Romain Felli
doaj   +1 more source

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