Results 91 to 100 of about 2,720,288 (295)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Impact of hydrostatic pressure on superconductivity of Sr0.5La0.5FBiS2

, 2014
We report the impact of hydrostatic pressure (0-1.97GPa) on superconductivity of recently discovered 2K superconductor Sr0.5La0.5FBiS2. Resistivity under pressure measurements are performed by using HPC-33 Piston type pressure cell with Quantum design DC
Awana, V. P. S., Jha, Rajveer, Tiwari, Brajesh   +2 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Observation of Fluctuation-Dissipation-Theorem Violations in a Structural Glass

, 1999
The fluctuation-dissipation theorem (FDT), connecting dielectric susceptibility and polarization noise was studied in glycerol below its glass transition temperature Tg.
A. Barrat, A. Einstein, A. Q. Tool, B. Schiener, B. Schiener, C. Donati, C. T. Moyniham, C. T. Moyniham, D. A. Stariolo, E. Marinari, G. H. Fredrickson, G. Parisi, G. Parisi, H. Barkhausen, H. Bouchiat, H. Nyquist, H. Yoshino, J.-L. Barrat, J.-L. Barrat, J.-P. Bouchaud, L. C. E. Struik, L. F. Cugliandolo, L. F. Cugliandolo, L. F. Cugliandolo, L. F. Cugliandolo, M. Ocio, N. E. Israeloff, N. E. Israeloff, N. E. Israeloff, N. O. Birge, N. O. Birge, O. S. Narayanaswamy, R. G. Palmer, R. Kubo, R. Kubo, R. L. Leheny, S. Franz, S. Franz, S. L. Simon, Tomás S. Grigera, W. R. Bennet, W. Reim   +41 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Instanton-noninstanton transition in nonintegrable tunneling processes: A renormalized perturbation approach

, 2014
The instanton-noninstanton (I-NI) transition in the tunneling process, which has been numerically observed in classically nonintegrable quantum maps, can be described by a perturbation theory based on an integrable Hamiltonian renormalized so as to ...
Hanada, Yasutaka, Ikeda, Kensuke S., Okushima, Teruaki, Shudo, Akira   +3 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The uneven foundations of a just transition for workers: a UK perspective

Frontiers in Climate
Assessments of the workforce impacts of net zero transitions have largely focussed on job losses, gains and net changes for a particular industry, sector or state.
Dave Reay
doaj   +1 more source

Finite temperature spin-dynamics and phase transitions in spin-orbital models

, 2009
We study finite temperature properties of a generic spin-orbital model relevant to transition metal compounds, having coupled quantum Heisenberg-spin and Ising-orbital degrees of freedom.
B. Moritz, C.-C. Chen, J. van den Brink, K. I. Kugel, R. R. P. Singh, T. P. Devereaux   +5 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source