Results 81 to 90 of about 391,277 (261)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
The uneven foundations of a just transition for workers: a UK perspective
Frontiers in ClimateAssessments of the workforce impacts of net zero transitions have largely focussed on job losses, gains and net changes for a particular industry, sector or state.
Dave Reay
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Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Religion, Extraction, and Just Transition in Appalachia
ReligionsThis paper employs approaches from religious studies and Appalachian studies to examine the history, influence, and future of a multifaceted ethos of extraction, particularly as it influences the coal industry, in the Appalachian region of the United ...
Joseph D. Witt
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Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Corrigendum to "Towards a theory of just transition: A neo-Gramscian understanding of how to shift development pathways to zero poverty and zero carbon" [Energy Res. Soc. Sci. 70 (2020) 101789]. [PDF]
Energy Res Soc Sci, 2023 Winkler H.
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Journal of SustainabilityAt the same time as the consequences of climate change are felt more acutely, the divide between positions in the climate debate grows deeper, making effective urban climate policies harder to realise than ever.
Hege Hofstad, Marianne Millstein
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