Results 111 to 120 of about 2,077,123 (300)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Brussels blog round up for 6 October – 12 October: Merkel inGreece, the Catalonia debate rages on, and EU wins the NobelPeace Prize. [PDF]
, 2012 Reaction to the EU’s 2012 Nobel Peace Prize award has been mixed. Open Europe draws a comparison with the “once celebrated actor who just got a lif etime achievement award”, arguing that while European integration did play a signif icant role in ensuring
Brown, Stuart A., Gilson, Chris
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Shakespearean Histories and Greek History: Henry V and Richard II at the Greek National Theatre (1941, 1947) [PDF]
, 2007 Henry V and Richard II made their first and only appearance on the Greek stage in the turbulent 1940s. The first was performed in March 1941, just before the arrival of the German nazis, and the second in November 1947, a year after the problematic ...
Krontiris, Tina
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
The End is Near: The Civil War in 1864
, 2015 In the minds of most Civil War lovers, the year 1864 marks the noticeable shift from a conciliatory war to a hard war. Most view it through the lens of Ulysses S. Grant’s Overland Campaign, through William Tecumseh Sherman’s March to the Sea, through the
Kirk, Brianna E.
core
Just War and the Indian Tradition: Arguments from the Battlefield [PDF]
, 2019 A famous Indian argument for jus ad bellum and jus in bello is presented in literary form in the Mahābhārata: it involves events and dynamics between moral conventionalists (who attempt to abide by ethical theories that give priority to the good) and ...
Ranganathan, Shyam
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source