Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
2. Toynbee and the Cyclical Pattern of History
There has been recently a return on the part of some writers to the Greek theory that the course of history follows a cyclical pattern. An important motivation for this return is the conviction that neither the theory of progress nor the classical ...
Bloom, Robert L. +6 more
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ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang +10 more
wiley +1 more source
The Chinese Meaning of Just War and Its Impact on the Foreign Policy of the People’s Republic of China [PDF]
The image of China’s peaceful rise, which the Chinese government is keen to enforce in the world, stands in contrast to the view of China’s ascent as a threat.
Nadine Godehardt
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Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi +19 more
wiley +1 more source
Еволюція феміністичного дискурсу війни: від антимілітаризму до етики піклування (The Evolution of Feminist Discourse of War From Antimilitarism to Ethics of Care) [PDF]
У статті проаналізовано феміністичний дискурс війни та його еволюція від антимілітаризму до етики піклування. Підкреслюється, що, спираючись на теорію справедливої війни та відходячи від суто гендерних ідентичностей, сучасні феміністки ...
Цимбал, Т. (T. Tsymbal)
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Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
From centralization to deconcentration: people and jobs spread out. [PDF]
During the first half of the 20th century, people and jobs in the United States moved from rural to urban areas. After World War II, the U.S. saw other important shifts, including deconcentration - the movement of people and jobs from large, dense MSAs ...
Gerald A. Carlino
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FDG‐PET Associations With Disease Severity and Outcomes in NMDA‐Receptor IgG Autoimmune Encephalitis
ABSTRACT Background Patients with N‐methyl‐D‐aspartate (NMDA) receptor‐immunoglobulin G (IgG) autoimmune encephalitis (NMDAR‐IgG AE) demonstrate occipital lobe hypometabolism on baseline brain fluorodeoxyglucose‐positron emission tomography (bFDG‐PET).
Jonathan K. Lee +7 more
wiley +1 more source
Whence Did German Propaganda Films Derive Their Power? [PDF]
In this essay, I review in great detail Ian Garden’s outstanding book, The Third Reich’s Celluloid War. Garden begins by discussing propaganda theory and then discusses not just Nazi feature films and documentaries, but television as well. (The Nazis had
Jason, Gary James
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