Results 41 to 50 of about 8,429,797 (274)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Killing and Dying for Public Relations
Conatus - Journal of Philosophy, 2023 My starting point is the first major American military action in World War II in Europe, “Operation Torch.” The action was controversial because the American military regarded it as militarily useless, if not counterproductive.
Cheyney Ryan
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
The 1948 war over Palestine and the just war theory
, 2018 Conferència a càrrec de Yitzhak Benbaji (Tel-Aviv University) sobre la teoria de la guerra justa en el cas de la Guerra de Palestina del 19485054.mp4 5054 ...
Benbaji, Yitzhak
core +2 more sources
Just Wars Theory as a Key Element of Germany’s New Sonderweg
Conatus - Journal of Philosophy, 2023 The article traces the evolution and key characteristics of the German Sonderweg – Germany’s special path starting from the end of the 19th – the middle of the 20th century. The article considers geopolitical, ideological, and historical reasons for its
Boris Kashnikov, Marina Glaser
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
, 2022 The fall of Kabul was and remains a big issue of concern that somewhat attracted various critical thoughts about wars. To some people, there is no better way to end the war because war is simply evil in all of its ramifications.
Omotoyinbo, Femi
core +3 more sources
ASSESSING MORAL TRAGEDY PACIFISM* [PDF]
KriterionPacifism and just war theory share the same binary approach to analyze the morality of war. According to binarism, any war is either morally justified or morally unjustified and when waging a war is morally unjustified, not waging that war is morally ...
Federico German Abal
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source