Results 61 to 70 of about 5,645,275 (159)
In Vivo Mapping of Catecholaminergic Loss and Iron Deposition in Huntington's Disease
Movement Disorders, Volume 41, Issue 5, Page 1257-1267, May 2026.Abstract Background The pathophysiology of Huntington's disease (HD) remains obscure. Magnetic resonance imaging (MRI) can reveal in vivo molecular changes related to disease pathology. Objectives To investigate catecholaminergic neuronal integrity and subcortical brain iron accumulation in HD employing neuromelanin‐sensitive MRI, and quantitative ...
Edoardo R. de Natale +11 more
wiley +1 more source
, 2017 "22 Years of predictive testing for Huntington’s disease: the experience of the UK Huntington’s Prediction Consortium" European Journal of Human Genetics (2016) 24, 1515; doi:10.1038/ejhg.2016.81 Corrigendum: 15 September 2016 European Journal of Human ...
Quarrell, Oliver W +1 more
core +1 more source
Neurobiology of Disease, 2009 The R6/2 mouse is the most common mouse model used for Huntington's disease (HD), a fatal, inherited neurodegenerative CAG disorder characterized by marked brain atrophy. We scanned 47 R6/2 transgenic and 42 wildtype (WT) ex vivo mouse brains at 18 weeks
S.J. Sawiak +4 more
doaj +1 more source
Brain and Behavior, Volume 16, Issue 4, April 2026.This study examined lifetime stressor exposure in adolescents at genetic risk for Huntington disease (HD) compared to community controls. At‐risk participants reported significantly greater lifetime stressor exposure than controls and were more likely to report externalizing problems such as rule‐breaking behavior when exposed to stress.
Katherine E. McDonell +7 more
wiley +1 more source
Juvenile-onset inflammatory arthritis: a study of adolescents' beliefs about underlying cause [PDF]
, 2012 Objective. Patients’ beliefs regarding the cause of illness may influence treatment adherence and long-term outcome. Little is known of adolescents’ beliefs regarding the cause of JIA. This study aims to identify adolescents’ beliefs about the underlying
Baildam, Eileen +19 more
core +1 more source
Juvenile idiopathic arthritis in two tertiary centres in the Western Cape, South Africa [PDF]
, 2011 Juvenile idiopathic arthritis (JIA) is defined as arthritis of unknown aetiology that begins before the 16th birthday and persists for at least 6 weeks, other conditions being excluded.
Weakley, Kate
core +1 more source
Huntington's disease: a clinical review
Orphanet Journal of Rare Diseases, 2010 Huntington disease (HD) is a rare neurodegenerative disorder of the central nervous system characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia.
Roos Raymund AC
doaj +1 more source
Biological Reviews, Volume 101, Issue 2, Page 911-925, April 2026.ABSTRACT Three categories of explanations exist for why we age: mechanistic theories, which omit reference to evolutionary forces; weakening force of selection theories, which posit that barriers exist that prevent evolutionary forces from optimising fitness in ageing; and optimisation theories, which posit that evolutionary forces actually select for ...
Michael S. Ringel
wiley +1 more source
The Clinical Manifestation of Homozygous Huntington's Disease
Clinical Case Reports, Volume 14, Issue 4, April 2026.ABSTRACT Huntington's disease is an incurable neurodegenerative disease with deficits in many areas including cognitive, psychiatric, and most notably, motor. It is autosomal dominant, meaning one affected allele is enough to express the condition.
Brishti Sengupta, Pritha Dasgupta
wiley +1 more source
Juvenile-onset Huntington’s disease: a challenging diagnosis
The clinical presentation of juvenile-onset Huntington’s disease differs from the adult-onset variant which adult neurologists are familiar. We report how we eventually arrived at this diagnosis in a patient whose clinical presentation was marked by ...
Toni Saad +3 more
core +1 more source