Results 131 to 140 of about 54,427 (263)

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, Volume 13, Issue 8, 9 February 2026.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Calprotectin in rheumatic diseases: a review

Rheumatology, 2016
Calprotectin also known as MRP8/14 or S100A8/A9 is a heterodimeric complex of two S100 calcium-binding proteins: myeloid-related protein 8 (MRP-8 or S100A8) and MRP-14 (or S100A9). At present, according to many authors, it is considered that calprotectin
Magdalena Kopeć-Mędrek, Małgorzata Widuchowska, Eugeniusz J. Kucharz   +2 more
doaj   +1 more source

Lymphocyte apoptosis and its association with the inflammatory markers and disease severity in juvenile-onset systemic lupus erythematosus patients

Pediatric Rheumatology Online Journal
The defective clearance of apoptotic bodies in juvenile-onset systemic lupus erythematosus (jSLE) potentially leads to the persistence of autoreactive lymphocytes and the perpetuation of the autoimmune response.
E. Eissa, Rania Kandil, D. Dorgham, Raghda M. Ghorab, N. Kholoussi   +4 more
semanticscholar   +1 more source

Tissue‐Resident Macrophage‐Derived E3 Ligase SMURF2 Restricts Autoimmune Inflammation by Mediating the Degradation of p‐TBK1

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Dysregulated Tissue resident macrophage (TRMs) link to autoimmune inflammation. SMURF2 mediates Lys‐27 (K27)‐linked ubiquitination of p‐TBK1 and its degradation, which inhibits CSF1R signaling‐triggered TRM proliferation, thereby restraining the autoimmune inflammation.
Xiang An, Jun Li, Lingling Wang, Chengyuan Li, Zhenpeng Jin, Yushi Yao, Minmin Jiang, Wenlong Lin, Xiaojian Wang   +8 more
wiley   +1 more source

Quality of life in patients with juvenile-onset systemic lupus erythematosus

Journal of V. N. Karazin Kharkiv National University: Series Medicine
Background. Childhood-onset systemic lupus erythematosus (cSLE) is a rare, multisystem, and potentially life-threatening autoimmune disease with significant comorbidities and the development of a chronic, debilitating condition for the patient.
L.F. Bohmat, N.S. Shevchenko, I.M. Bessonova, T.O. Holovko   +3 more
doaj   +1 more source

Neonate mortality in mountain caribou: Patterns of predation during onset of a wolf reduction program

The Journal of Wildlife Management, Volume 90, Issue 2, February 2026.
We used an individual‐based movement method, supported by camera trap data, to assess changes in neonate caribou mortality patterns before and after wolf reduction began in the Itcha‐Ilgachuz mountain caribou subpopulation range, British Columbia, Canada.
Tazarve Gharajehdaghipour, Marie Auger‐Méthé, A. Cole Burton   +2 more
wiley   +1 more source

IKAROS Associated Immunodeficiency and Thrombotic Thrombocytopenic Purpura

Pediatric Blood &Cancer, Volume 73, Issue 2, February 2026.
ABSTRACT Pathogenic variants in IKZF1 (IKAROS) are linked to immunodeficiency, malignancy, and immune dysregulation. We describe a family with a rare IKZF1 variant presenting with humoral immunodeficiency and thrombotic thrombocytopenic purpura (TTP). A non‐consanguineous family was clinically monitored; clinical, immunological, and genetic data (exome
Ilia Spivak, Daniella Magen, Karin Weiss, Tamar Paperna, Suhair Hanna, Amos Etzioni, Adi Miller‐Barmak, Yonatan Butbul Aviel   +7 more
wiley   +1 more source

OA08 Ocrelizumab in pregnancy in a patient with juvenile onset systemic lupus erythematosus

Rheumatology Advances in Practice
Introduction Juvenile-onset systemic lupus erythematosus (jSLE) is a multisystem autoimmune disease that results in increased disease activity compared to adult-onset SLE.
Yasir Suleman-Raza, Debajit Sen, Corinne Fisher, Maria Mouyis   +3 more
semanticscholar   +1 more source

Oral lesions in adult- and juvenile-onset systemic lupus erythematosus patients: A case series report.

Dental and Medical Problems
Systemic lupus erythematosus (SLE) is an autoimmune disease with various oral manifestations, including ulceration, white keratotic plaques, oral discoid lupus erythematosus, oral lichen planus (OLP)-like lesions, non-specific erythema, purpura ...
F. Hartanto, I. Sufiawati
semanticscholar   +1 more source

Belimumab in a Patient with Systemic Lupus Erythematosus with Juvenile Onset and Steroid-induced Diabetes: Clinical Case

Current Pediatrics
Background. The management of children with systemic lupus erythematosus (SLE) is usually associated with lifelong systemic glucocorticoids administration and, thereby, high risk of serious side effects, including steroid-induced diabetes. The belimumab (
M. Kaleda, I. Nikishina, Alesya V. Firsa
semanticscholar   +1 more source