Results 91 to 100 of about 3,652 (213)

CRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti‐tumoral compounds

Molecular Oncology, Volume 19, Issue 4, Page 1092-1116, April 2025.
FOXL2 c.402C>G mutation drives granulosa cell tumors. Using CRISPR technology, we selectively corrected this mutation, reducing malignancy and increasing sensitivity to dasatinib and ketoconazole. Transcriptomic changes revealed potential therapeutic targets, demonstrating CRISPR's promise for treating this rare ovarian cancer.
Sandra Amarilla‐Quintana, Paloma Navarro, Iván Hernández, Alejandra Ramos, Ana Montero‐Calle, Pablo Cabezas‐Sainz, Maria J Barrero, Diego Megías, Borja Vilaplana‐Martí, Carolina Epifano, Déborah Gómez‐Dominguez, Sara Monzón, Isabel Cuesta, Laura Sánchez, Rodrigo Barderas, Jesús García‐Donas, Alberto Martín, Ignacio Pérez de Castro   +17 more
wiley   +1 more source

Premature ovarian failure and ovarian autoimmunity [PDF]

, 1997
Premature ovarian failure (POF) is defined as a syndrome characterized by menopause before the age of 40 yr. The patients suffer from anovulation and hypoestrogenism.
A. Hoek, Aaltonen, Ahonen, Ahonen, Aiman, Allison, Allison, Alper, Alper, Alper, Anasti, Anasti, Atria, Austin, Austyn, Austyn, Austyn, Ayala, Baker, Bannatyne, Batchelor, Bateman, Baumann-Antczak, Behrman, Belvisi, Betterle, Betz, Biddison, Bierer, Biscotti, Blizzard, Block, Blumenfeld, Board, Bohmig, Borst, Bottazzo, Bottazzo, Bottazzo, Brenner, Brenner, Burton, Byrne, Cameron, Campbell, Caux, Chamberlin, Charlton, Chen, Chiauzzi, Colle, Collen, Collins, Cooper, Corenblum, Costoff, Coulam, Coulam, Coulam, Coulam, Coulam, Coulam, Coulam, Cowchock, Dahl, Damewood, Damjanovic, Damjanovic, Day, de Moraes-Ruehsen, de Moraes-Ruehsen, Dean, DeGroot, Dewhurst, Duignan, d’Andrea, Edmonds, Elder, Emperaire, Emperaire, Epplen, Escobar, Falk, Falk, Fitch, Fitzgerald, Flechner, Fraser, Fraser, Freudenthal, Friedman, Friedman Cl Gurgen-Varol, Furmaniak, Germain, Gloor, Golonka, Goodnow, Green, Greenberger, Greiner, Griffin Jr, H. A. Drexhage, Hanafusa, Harding, Hart, Hart, Hart, Heller, Hens, Herberman, Hill, Ho, Ho, Hoek, Hoek, Horning, Inaba, Irvine, Irvine, Ivanova, Iwatani, J. Schoemaker, Jackson, Jackson, Jankovic, Jansen, Jaroudi, Jaszmann, Jeppsson, Jia, Jin, Johnson, Jones, June, Kabel, Kamada, Kamperdijk, Kappler, Kaufman, Kiessling, Kim, Kimura, Kinch, Koninckx, Krailo, Krauss, Krawinkel, Kroemer, Krohn, Kuki, Labarbera, Lanier, Lanier, Le Floch, Leder, Leenen, Leibovich, Linsley, Lonsdale, Lou, Luborsky, Lundberg, Luo, Many, Marazuela, Marrack, Mathur, Mathur, Mattison, Maxson, McNatty, Meeker, Menon, Meuer, Mignot, Mignot, Milgrom, Miller, Miller, Miyake, Miyake, Mohler, Monaco, Moncayo, Moncayo, Moncayo-Naveda, Moore, Morahan, Morrison, Mosmann, Moss, Muechler, Mueller, Muir, Munoz, Munro Neville, Murphy, Myers, Nagler, Neefjes, Nelson, Nelson, Norton, Nossal, Oettgen, Panidis, Parker, Pekonen, Perussia, Philip, Pierce, Plunkett, Podack, Powrie, Prickett, Prinz, Pure, Quill, Rabinowe, Rabinowe, Rabinowe, Rebar, Rebar, Rhim, Rock, Romagnani, Royer, Rudensky AYu Preston-Hulburt, Russell, Sakaguchi, Sakaguchi, Sakaguchi, Sakaguchi, Schreiber, Schwartz, Scott, Seaman, Sedmak, Sele, Serreze, Shangold, Sharf, Shimizu, Singh, Skinner, Sluss, Smith, Smith, Smith, Smith, Song, Sotsiou, Starup, Starup, Steinman, Strominger, Suda, Taguchi, Taguchi, Taguchi, Tang, Tas, Teh, Teunissen, Theofilopoulos, Tilly, Todd, Tonegawa, Townsend, Trinchieri, Trunca, Tsirigotis, Tung, Turkington, Uibo, Uibo, Vakkila, Vallotton, van Dongen, van Ewijk, van Furth, van Voorhis, van Weissenbruch, Velloso, Villanueva, Volpe, Voorbij, Voorbij, Walfish, Walsh, Wardell, Warne Gl Fairley, Waxman, Weetman, Wheatcroft, Whitehead, Wick, Wick, Wick, Williamson, Winqvist, Winqvist, Winqvist, Witmer, Wolfe, Wolffenbuttel, Wood, Wright, Wulffraat, Yamakawa, Yen, Yoon, Yuan, Zarate, Zarate, Zourlas   +315 more
core   +3 more sources

Treatment of Peripheral Precocious Puberty [PDF]

, 2015
There are many etiologies of peripheral precocious puberty (PPP) with diverse manifestations resulting from exposure to androgens, estrogens, or both. The clinical presentation depends on the underlying process and may be acute or gradual.
Eugster, Erica A., Schoelwer, Melissa
core   +1 more source

An autocrine role for pituitary GABA: Activation of GABA-B receptors and regulation of growth hormone levels [PDF]

, 2002
There is increasing evidence suggesting that the neurotransmitter gamma-aminobutyric acid (GABA) is a local factor involved in the regulation of endocrine organs.
Corsi, C., Gamel-Didelon, Katia, Gratzl, M., Jung, H., Mayerhofer, Artur, Pepeu, G.   +5 more
core   +1 more source

Clinicopathological evaluation of ovarian juvenile granulosa cell tumor: Is fertility-sparing surgery safe?

Reproductive and Developmental Medicine, 2019
Objective: To retrospectively investigate the clinicopathological characteristics of ovarian juvenile granulosa cell tumors (JGCTs) and to evaluate the safety of fertility-sparing surgery.
Lu Guo, Xiao-Cheng Liu, Xiu-Ying Chen, Xi-Rong Xiao, Yu-Qing Qu, Bin Li   +5 more
doaj   +1 more source

Bilateral ovarian juvenile granulosa cell tumor in a neonate with Donohue syndrome: a case report and review of literature

Egyptian Pediatric Association Gazette
Background Hereditary severe insulin resistance syndrome (H-SIRS) is a group of disorders classified into four principal categories: primary insulin receptor defects, lipodystrophies, complex genetic syndromes, and obesity-related H-SIRS.
Amany Reda Elbahbity, Amr Abdelhamid AbouZeid, Mohammad Hassan Mohamed, Mohammad Hassan Elibiary, Soha M. khafagy, Amira Mostafa Rashad, Shaimaa Mahmoud Abdelraouf, Sohair Abdelbaset Zayed, Manal Fawzy Gadalla, Shaimaa Abdelsattar Mohammad   +9 more
doaj   +1 more source

Juvenile granulosa cell tumor in a teenager: a case report

Journal of Pediatric Surgery Case Reports
Introduction: Juvenile granulosa cell tumors (JGCTs) are rare ovarian sex cord–stromal neoplasms that primarily affect young females and are often detected early due to hyperestrogenic manifestations.
Ian Cummings-Ruiz, Nicole A. Martínez-Martínez, Kenneth Avilés-Fernández, Yaiel Rodríguez-Avilés, Victor Ortiz-Justiniano   +4 more
doaj   +1 more source

Granulosa cell tumor of the testis in a newborn

Autopsy and Case Reports, 2014
Testicular neoplasms are uncommon tumors of childhood. These tumors comprise the germ cell tumors, and other tumors that may originate from histological testicular components, which are unrelated to the germinal lineage. Among the latter are the sex cord-
Oliver Rojas Claros, Américo Toshiaki Sakai, Horácio Consolmagno, Marcos de Paula Nogueira, Leonardo Abreu Testagrossa, Oscar Eduardo Hidetoshi Fugita   +5 more
doaj   +1 more source

Juvenile granulosa cell tumor in a transgender male with Ollier disease: A case report. [PDF]

Gynecol Oncol Rep, 2023
Ing BI, Huepenbecker SP, Hameed N, Lu KH.   +3 more
europepmc   +1 more source

Case report of a 3-year-old girl with pleuropulmonary blastoma and family history of a tumor predisposition syndrome with c. 2830 gene mutation in DICER1

Journal of Pediatric Surgery Case Reports, 2015
Pleuropulmonary blastoma (PPB) is a childhood mesenchymal pleural-based tumor that is associated with a germline mutation in DICER1 gene in familial PPB. It occurs most commonly in children between the ages of 2 and 5.
Y. Puckett, J. Howe, D. Vane, A. Agarwal, J.R. Batanian, J. Greenspon   +5 more
doaj   +1 more source