Results 31 to 40 of about 3,713 (208)

Constitutively active transforming growth factor β receptor 1 in the mouse ovary promotes tumorigenesis [PDF]

, 2016
Despite the well-established tumor suppressive role of TGFβ proteins, depletion of key TGFβ signaling components in the mouse ovary does not induce a growth advantage.
Bartholin, Laurent, Davis, Anna Jane, Gao, Yang, Li, Qinglei, Sansom, Owen, Vincent, David   +5 more
core   +1 more source

Perspectives on testicular sex cord-stromal tumors and those composed of both germ cells and sex cord-stromal derivatives with a comparison to corresponding ovarian neoplasms [PDF]

, 2017
Sex cord-stromal tumors (SCSTs) are the second most frequent category of testicular neoplasms, accounting for approximately 2–5% of cases. Both genetic and epigenetic factors account for the differences in frequency and histologic composition between ...
Cheng, Liang, Lyu, Bingjian, Roth, Lawrence M.   +2 more
core   +1 more source

Granulosa Cell Tumour – A Rare Presentation at Age Twenty

Pakistan Journal of Medicine and Dentistry, 2020
Granulosa cell tumor is a rare type of ovarian tumor, which arises from sex cord stroma. Histologically this tumor has two types and is named according to the common age group they affect; adult granulosa cell tumor (AGCT) and juvenile granulosa cell ...
Munazza Ani, Shama Chaudhary, Rahima Rais, Rubina Hussain, Sayeda Naseer   +4 more
doaj   +1 more source

Nuclear localization of β-catenin in Sertoli cell tumors and other sex cord–stromal tumors of the testis: an immunohistochemical study of 87 cases [PDF]

, 2015
The diagnosis and subclassification of Sertoli cell tumors (SCT) of the testis are often challenging to general surgical pathologists because of the rarity of the tumors. Immunohistochemical study to date has limited diagnostic value.
Ulbright, Thomas M., Zhang, Chen
core   +1 more source

Juvenile granulosa cell tumour of the ovary presenting with hyperprolactinaemic amenorrhoea and galactorrhoea [PDF]

, 2016
Secondary amenorrhoea and galactorrhoea represent a common endocrine presentation. We report a case of an oestrogen-producing juvenile granulosa cell tumour (JGCT) of the ovary in a 16-year-old post-pubertal woman with hyperprolactinaemia amenorrhoea and
Iqbal, A., Kew, F.M., Lubina-Solomon, A., Novodvorsky, P., Webster, J.   +4 more
core   +1 more source

Testicular and ovarian Juvenile granulosa cell tumors in children and adolescents: Analysis of 113 patients registered to the German Registry for Rare Pediatric Tumors (STEP). [PDF]

Cancer
Abstract Background In juvenile granulosa cell tumors (juvGCTs), impaired survival was reported after preoperative tumor rupture, peritoneal metastases, or high mitotic rate (≥20 mitoses per 10 high‐power fields). Therefore, a risk stratification was developed to select patients for chemotherapy. Methods Between 2001 and 2019, 89 female patients and 24
Schneider DT, Witowski A, Abele M, Benesch M, Bernbeck B, Blessing T, Brummel B, Calaminus G, Göbel U, Graf N, Vokuhl C, Schultz KAP, Brecht IB.   +12 more
europepmc   +2 more sources

Juvenile Granulosa Cell Tumors of the Testis: A Clinicopathologic Study of 70 Cases with Emphasis on Its Wide Morphologic Spectrum [PDF]

, 2015
The clinical and pathologic features of 70 juvenile granulosa cell tumors (JGCTs) of the testis are presented. The patients were from 30 weeks gestational age to 10 years old; 60 of 67 (90%) whose ages are known to us were 6 months old or younger.
Cornejo, Kristine M., Kao, Chia-Sui, Ulbright, Thomas M., Young, Robert H.   +3 more
core   +1 more source

Adult-Type Granulosa Cell Tumor of the Testis: A Report of a Case and a Discussion of the Literature

Uro, 2023
Testicular granulosa cell tumors (TGCTs) are rare tumors of sex cord-stromal origin. TGCTs are classified into two main categories, the adult type and the juvenile type.
Georgios Zervopoulos, Nikolaos Mitsimponas, Filippos Venetsanos, Athanasios Papathanasis   +3 more
doaj   +1 more source

Tracing metastatic spread in pediatric solid tumors using copy number and targeted deep sequencing. [PDF]

J Pathol
Abstract The most common cause of death in pediatric cancer patients is a treatment‐resistant tumor, compounded by metastatic spread, making surgery, radiation therapy, and chemotherapy unfeasible as curative treatment options. However, the mechanisms behind metastatic spread in pediatric tumors remain largely unexplored. We conducted whole‐genome copy
Andersson N, Ferro M, Jansson C, Chattopadhyay S, Karlsson J, Gisselsson D.   +5 more
europepmc   +2 more sources

Regulation of ovarian function: the role of anti-Mullerian hormone [PDF]

, 2002
Anti-Mullerian hormone (AMH), also known as Mullerian inhibiting substance, is a member of the transforming growth factor beta superfamily of growth and differentiation factors.
Durlinger, A.L.L. (Alexandra), Themmen, A.P.N. (Axel), Visser, J.A. (Jenny)   +2 more
core   +2 more sources