Results 101 to 110 of about 430,506 (249)

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Maternal microbiota shapes brain and neuroendocrine development in piglets

iMeta, EarlyView.
Using germ‐free and maternal microbiota‐transplanted piglets, we constructed an integrated multi‐organ atlas combining snRNA‐seq, Stereo‐seq, intestinal transcriptomics, and metabolomics. Maternal microbiota transplantation was associated with neuronal and glial remodeling, altered neuron–glia communication involving NRG1/3–ERBB4 signaling, trends ...
Leli Wang, Chao Yan, Lei Li, Yuankun Deng, Hua Shao, Kuo Long, Cimin Long, Yuanyuan Zhu, Meiqing Chen, Jialu Huang, Jinghua Jiang, Ziyi Lin, Yunying Yao, Tao Yang, Wenbin Guo, Liangpeng Ge, Jing Sun, Yuchun Ding, Zuohua Liu, Mingzhu Yin, Yulong Yin   +20 more
wiley   +1 more source

District 6 Juvenile Justice Council Meeting Minutes

, 2021
Idaho Dept. of Juvenile Corrections, Juvenile Justice Council meeting minutes from Jan.
Juvenile Corrections, Idaho Dept. of, Juvenile Justice Council;
core   +1 more source

Cost Study of Youth Residential Centers for Juvenile Offenders Pursuant to Senate Substitute for House Bill 2588

, 2015
application/pdf; "January 15, 2015."; Includes bibliographical references."The Kansas Juvenile Justice System relies heavily upon Youth Residential Center II (YRCII) placements, spending in excess of $16 million in Fiscal Year 2014 (FY14 ...
Kansas. Department of Corrections. Division of Juvenile Services.
core   +1 more source

Influence of 17α-Methyltestosterone on Morphological Deformities and Pigmentation Development in Juvenile Japanese Eels, Anguilla japonica

Animals
17α-methyltestosterone (MT) is a synthetic steroid used to induce masculinization when administered during the larval stage of fish. However, the side effects of MT on eel are still poorly understood and, in this study, we examined the various effects of
Ju-Ae Hwang, Jun Seong Park, Hae Seung Jeong, Seong Don Hwang   +3 more
doaj   +1 more source

Dose‐Dependent Efficacy of Radioiodine Therapy in Pediatric Graves’ Disease: A Retrospective Study of Hypothyroidism Risk and the Predictive Role of Thyroid Hormone Parameters

iRADIOLOGY, EarlyView.
RAI therapy demonstrated time‐dependent efficacy in pediatric Graves' disease, with gradually increasing treatment success and hypothyroidism incidence during follow‐up. Higher planned activity (≥ 0.15 mCi/g) was associated with a higher successful rate than lower planned activity (< 0.15 mCi/g), and LASSO analysis identified FT3 and TSH as candidate ...
Xiaoxue Tian, Dan Zhang, Yihui Wang, Lujie Cao, Junpu Jian, Jiangyan Liu, Changping Liang, Yinzhong Wang, Yonghui Chen   +8 more
wiley   +1 more source

Juvenile hormone regulates the maturation of sexually dimorphic naive ethanol olfactory preference in Drosophila melanogaster

Royal Society Open Science
The molecular mechanisms underlying the maturation of innate reward behaviours remain poorly understood. We have identified a sexually dimorphic innate reward behaviour in Drosophila melanogaster that varies depending on the age, sex and mating status in
Antonio Marini-Davis, Ryan Oliver, Bailey Godwin, Sera Chase, Ziam Khan, Fernando J. Vonhoff   +5 more
doaj   +1 more source

Effects of Glyphosate and Glyphosate‐Based Herbicides on the Mammalian Gut Microbiome: A Critical Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Glyphosate has long been considered to pose negligible direct risk to mammals on the grounds that its molecular target, 5‐enolpyruvylshikimate‐3‐phosphate synthase (EPSPS), of the shikimate pathway, is absent from animal cells. This rationale is inaccurate as a complete toxicological argument, because the shikimate pathway is present in some ...
Robin Mesnage
wiley   +1 more source

Annual report (Arizona Juvenile Justice Commission) [PDF]

, 2003
The Arizona Juvenile Justice Commission, in conjunction with the Governor's Office for Children, Youth and Families, works to create conditions in Arizona's communities that promote juvenile justice and the positive development of youth, reduce youth ...

core  

Offspring Global DNA Methylation is not Affected by Parental Developmental Stress Experience in a Passerine Species

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Rapid phenotypic change may be mediated by intergenerational transmission of early developmental experiences. In birds, exposure to glucocorticoids during early development can alter global DNA methylation and gene expression. However, DNA methylation is labile, and it is currently unclear whether the impacts of stress suffered during juvenile
Anna Miltiadous, Harrison J. F. Eyck, Ondi L. Crino, Lee A. Rollins, Damien Callahan, Katherine L. Buchanan   +5 more
wiley   +1 more source