Results 171 to 180 of about 430,506 (249)

Evidence That the Protein Phosphatase Activity of PTEN Contributes to Embryonic Development and Tumor Suppression

Cancer Science, EarlyView.
Mice expressing only mutant PTEN Y138L, a protein which shows normal suppression of cellular AKT yet lacks protein phosphatase activity, die in utero, and heterozygous mice display a range of tumors. This indicates both the lipid and protein phosphatase activities of PTEN work together for normal tumor suppression and embryonic development.
Priyanka Tibarewal, Laura Spinelli, Nisha Kriplani, Helen Wise, Nadege Poncet, Giulia Marzano, Karen E. Anderson, Katarzyna M. Grzes, Zofia Varyova, Mahreen Adil, C. Peter Downes, Phillip T. Hawkins, Len R. Stephens, Kate G. Storey, Doreen A. Cantrell, Bart Vanhaesebroeck, Nicholas R. Leslie   +16 more
wiley   +1 more source

Larval character evolution in Holometabola (Insecta)

Cladistics, EarlyView.
Abstract Larvae, a novel type of immature stage, are a crucial innovation of the Holometabola. Larval features therefore provide key evidence for reconstructing evolutionary transformations in this megadiverse group. Here we present the first formal reconstruction of larval character evolution, using maximum parsimony and Bayesian ancestral‐state ...
Rolf Georg Beutel, Jakub Goczał, Di Li
wiley   +1 more source

Fibrillar‐Type Dermatitis Herpetiformis: An Underrecognized Variant That Is Rarely Associated With Celiac Disease and Lacking Epidermal Transglutaminase Deposition: A Report of Two Cases

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Dermatitis herpetiformis (DH) is a rare, intensely pruritic cutaneous manifestation of celiac disease (CD), typically presenting with excoriated papulovesicular lesions on extensor surfaces. DH is associated with IgA autoantibodies against epidermal transglutaminase (eTG), which form granular immune deposits in the papillary dermis and induce ...
Jeffrey Damman, Elodie Mendels, Sven van der Woude, Sharon Veenbergen, Gilles F. H. Diercks, Martijn B. van Doorn   +5 more
wiley   +1 more source

Disseminated Xanthogranuloma Harboring a GAB2::BRAF Fusion and MITF Pathogenic Variant Successfully Treated With Cobimetinib: A Rare Case Report

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Several activating mutations and gene fusions involving the mitogen‐activated protein kinase (MAPK) pathway have appeared in the literature regarding histiocytic neoplasms. We identified a GAB2::BRAF fusion in a cutaneous lesion of a 36‐year‐old male who developed central diabetes insipidus and reddish‐pink grouped papules on the bilateral ...
Pauline C. Xu, Allison M. Cushman‐Vokoun, Christopher R. D’Angelo, Dinesh Pradhan   +3 more
wiley   +1 more source

International consensus recommendations for identifying malnutrition in children with neurological impairment

Developmental Medicine &Child Neurology, EarlyView.
Abstract Children with neurological impairment (CNI) are at increased risk of malnutrition because of functional, medical, and socioeconomic challenges. However, difficulties in obtaining reliable anthropometric measurements and differences in body composition limit the usefulness of conventional nutritional indicators.
Sarah Vermilyea, Jodi Wolff, Gina Rempel, Jessie M. Hulst, Koen Huysentruyt, Mandy Neudecker, Denise Kennedy, Valérie Marchand, Erika Ochoa‐Ortiz, Richard D. Stevenson, Promoting International Collaboration for Nutrition in Neurological Impairment in Children (PICNNIC) Working Group, Lucinda Lourens, Mark Conaway, Tejas S. Desai, Mercedes Ruiz Brunner, Nathalia Sanchez Vargas, Valeria Martinez Tenorio, Kristie L. Bell, Claudio Romano, Richard Grossberg   +19 more
wiley   +1 more source

New insights into β‐cell vulnerability in type 1 diabetes—Lessons from nature

Diabetic Medicine, EarlyView.
Abstract Type 1 diabetes results from an autoimmune‐mediated destruction of pancreatic β‐cells, yet considerable heterogeneity exists regarding disease onset, progression and severity. Emerging evidence suggests that this variability reflects not only differences in immune responses, but also differences in the architecture and immune landscape of the ...
Kathryn Murrall, Teifion Luckett, Christiana Lekka, Stephanie L. Hunter, Sylvie Agnello, Peter Ferris, Emma Haxton, Christine S. Flaxman, Abirami Kannan, Xinpeng Dun, Sarah J. Richardson   +10 more
wiley   +1 more source

Assessing Predator Activity on Clay Models in Response to Common Insecticides in Turfgrass

Entomologia Experimentalis et Applicata, EarlyView.
Insecticides exhibited clear but time‐dependent effects on predatory activity, as reflected by impression types and density on clay models in turfgrass. Certain insecticides (bifenthrin, and in some cases acephate + imidacloprid, imidacloprid, chlorantraniliprole, and tetraniliprole) reduced total impressions shortly after application and again later ...
Mahesh Ghimire, Shimat V. Joseph
wiley   +1 more source

Corpses as Repositories of Information and Funerals as Information Centres: Why Natural Selection Favours the Bereaved

Ethology, EarlyView.
Corpses are repositories of information about the cause of death. The distress of the bereaved acts as an honest signal drawing conspecifics to the body, enabling them to learn quickly about the death, adapt their behaviour, and spread knowledge of threats across multiple social levels.
Jacob Dembitzer, Dror Ben‐Ami
wiley   +1 more source

The Company We Keep: Effects of Different Social Environments on Male Guinea Pig Behaviour and Hormones Over the Course of the Ontogeny

Ethology, EarlyView.
To examine how their behaviour and hormones change over different life phases, male guinea pigs experienced two different social environments from juvenility to adulthood. Only one environment contained social stimulation by unfamiliar conspecifics. Although no differences in testosterone and cortisol concentrations were found, it was interesting that ...
Maximilian Baldy, Sylvia Kaiser
wiley   +1 more source

From Social Experience to Social Behaviour: Hormonal and Behavioural Phenotypes During Adolescence in Male Guinea Pigs

Ethology, EarlyView.
To investigate how different social environments during adolescence influence hormones and behaviour, adolescent male guinea pigs were pair‐housed with a female either with or without additional social stimulation through repeated brief encounters with unfamiliar conspecifics.
Melanie Gleske, Carolin Mundinger, S. Helene Richter, Sylvia Kaiser   +3 more
wiley   +1 more source