Results 71 to 80 of about 5,067,029 (185)

Sex‐specific reproductive investment and survival of Atlantic salmon kelts across multiple dams

Ecosphere, Volume 17, Issue 8, August 2026.
Abstract In adult Atlantic salmon, individual variation in migration and movement within rivers during spawning (i.e., reproductive movement, RM) is an important component of overall reproductive investment that may influence subsequent survival and repeat spawning.
Kurt C. Heim, Jonah L. Withers, Aaron Heisey, William R. Ardren, Laurie A. Earley, Theodore Castro‐Santos   +5 more
wiley   +1 more source

Targeting the cholinergic system to develop a novel therapy for Huntington's disease

, 2016
In this review, we outline the role of the cholinergic system in Huntington's disease, and briefly describe the dysfunction of cholinergic transmission, cholinergic neurons, cholinergic receptors and cholinergic survival factors observed in post-mortem ...
D'Souza, GX, Waldvogel, Henry
core   +1 more source

From Synapses to Circuits, the Role of KIBRA and the WWC Family in Adaptive Brain Function

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
KIBRA (WWC1) has been the subject of scientific interest since its initial association with nonpathological variation in human memory performance. This review discusses subsequent work in animal models demonstrating that KIBRA supports memory function.
Lenora J. Volk
wiley   +1 more source

Brain structure in juvenile-onset Huntington disease [PDF]

Neurology, 2019
To assess brain morphometry in a sample of patients with juvenile-onset Huntington disease (JOHD) and several mouse models of Huntington disease (HD) that likely represent the human JOHD phenotype.Despite sharing the mutation in the Huntingtin gene, adult-onset HD characteristically presents as a hyperkinetic motor disorder, while JOHD typically ...
Alexander Tereshchenko, Vincent Magnotta, Eric Epping, Katherine Mathews, Patricia Espe-Pfeifer, Erin Martin, Jeffrey Dawson, Wenzhen Duan, Peg Nopoulos   +8 more
openaire   +2 more sources

Three Generations of Huntington’s Disease in a Family-Diagnosed after Juvenile Presentation in an Adolescent: A Case Report

Indian Pediatrics Case Reports
Background: Huntington’s disease (HD) is a neurodegenerative disorder characterized by dominant inheritance, choreoathetosis, cognitive decline, and psychiatric disturbances.
Keerthana Muralidhar, Muganagowda Patil
doaj   +1 more source

The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington’s disease patients

Scientific Reports, 2017
We have previously shown that exon 1 of the huntingtin gene does not always splice to exon 2 resulting in the production of a small polyadenylated mRNA (HTTexon1) that encodes the highly pathogenic exon 1 HTT protein.
Andreas Neueder, Christian Landles, Rhia Ghosh, David Howland, Richard H. Myers, Richard L. M. Faull, Sarah J. Tabrizi, Gillian P. Bates   +7 more
doaj   +1 more source

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, Volume 13, Issue 6, Page 1206-1221, June 2026.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

The psychological experience of living at risk of an autosomal dominant neurological condition: A scoping review

Alzheimer's &Dementia: Behavior &Socioeconomics of Aging, Volume 2, Issue 2, June 2026.
Abstract As our understanding of genetic risk and the availability of genetic testing increases, consideration of the psychological impact of living at risk for an autosomal dominant neurological condition (ADNC) becomes more pertinent. A systematic search of PsycINFO, MEDLINE, and Web of Science was run to identify studies exploring the psychological ...
Rhianna Brien, Simon Mead, Marc Tibber, Edgar Chan   +3 more
wiley   +1 more source

Corticostriatal maldevelopment in the R6/2 mouse model of juvenile Huntington's disease

Neurobiology of Disease
There is a growing consensus that brain development in Huntington's disease (HD) is abnormal, leading to the idea that HD is not only a neurodegenerative but also a neurodevelopmental disorder.
Carlos Cepeda, Sandra M. Holley, Joshua Barry, Katerina D. Oikonomou, Vannah-Wila Yazon, Allison Peng, Deneen Argueta, Michael S. Levine   +7 more
doaj   +1 more source

Neutral theory: applicability and neutrality of clinical study endpoints where a disease-specific instrument is available

BMC Medical Research Methodology, 2023
Background There is a pressing need to improve the accuracy of rare disease clinical study endpoints. Neutral theory, first described here, can be used to assess the accuracy of endpoints and improve their selection in rare disease clinical studies ...
Ravi Jandhyala
doaj   +1 more source