Results 91 to 100 of about 83,768 (184)
British Journal of Pharmacology, Volume 183, Issue 2, Page 280-295, January 2026.Background and purpose Patients with amyotrophic lateral sclerosis (ALS) are prescribed many medications for symptomatic relief. However, how potential alterations to the blood–brain barrier (BBB) affect the brain exposure of drugs in ALS remains under‐investigated. Experimental approach We used high‐dimensional proteomic analysis, cellular metabolism,
Yijun Pan +10 more
wiley +1 more source
Brazilian Journal of Medical and Biological Research, 2006 Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that affects the striatum most severely. However, except for juvenile forms, relative preservation of the cerebellum has been reported.
H.H. Ruocco +4 more
doaj +1 more source
Dysbiosis and Therapeutic Modulation of the Gut Microbiota in Multiple Sclerosis: A Narrative Review
Health Science Reports, Volume 8, Issue 12, December 2025.ABSTRACT Background and Aims Multiple sclerosis (MS) is a persistent autoimmune disease that affects the central nervous system. The etiology of MS is complex, involving a variety of genetic and environmental factors. Mounting evidence suggests that dysbiosis significantly impacts the progression of MS mainly through its direct effects upon the immune ...
Mojtaba Memariani, Hamed Memariani
wiley +1 more source
4472 Plasma Neurofilament Light as a Biomarker for Pediatric Patients with Huntington’s Disease
Journal of Clinical and Translational Science, 2020 OBJECTIVES/GOALS: The goal of this study is to compare plasma neurofilament light (NfL) concentrations in asymptomatic children and young adults that carry the gene expansion (GE group) that causes Huntington’s Disease to similar subjects that do not ...
Jordan L Schultz
doaj +1 more source
Volume Estimation of the Thalamus Using Freesurfer and Stereology: Consistency between Methods [PDF]
, 2012 Freely available automated MR image analysis techniques are being increasingly used to investigate neuroanatomical abnormalities in patients with neurological disorders.
Christoph Kellinghaus +9 more
core +1 more source
MedComm, Volume 6, Issue 12, December 2025.Protein arginine methyltransferase 1 (PRMT1) is a pivotal enzyme that catalyzes the asymmetric dimethylation of arginine residues, thereby functioning as a critical epigenetic regulator of diverse biological processes such as gene expression, RNA splicing, and DNA repair.
Yanqun Luo +4 more
wiley +1 more source
Neurobiology of Disease, 2009 The R6/2 mouse is the most common mouse model used for Huntington's disease (HD), a fatal, inherited neurodegenerative CAG disorder characterized by marked brain atrophy. We scanned 47 R6/2 transgenic and 42 wildtype (WT) ex vivo mouse brains at 18 weeks
S.J. Sawiak +4 more
doaj +1 more source
Physical exercise-induced adult neurogenesis: A good strategy to prevent cognitive decline in neurodegenerative diseases? [PDF]
, 2014 published_or_final_versio
Christie, BR +3 more
core +4 more sources
A Zebra in Horse's Clothing: Rethinking the Diagnosis of Rare Diseases
Molecular Genetics &Genomic Medicine, Volume 13, Issue 12, December 2025.We analyze rare diseases with common presentations to reexamine genetic testing principles. In proposing criteria that emphasize patient capacity, test utility, and proportional invasiveness, we highlight gaps between guidelines and current practice. Coordinated, patient‐centered approaches are critical to maximize benefits, minimize harms, and inform ...
Rajeev Dutta +3 more
wiley +1 more source
Regulation of hippocampal synaptic function by the metabolic hormone, leptin:Implications for health and neurodegenerative disease [PDF]
, 2018 The role of the endocrine hormone leptin in controlling energy homeostasis in the hypothalamus are well documented. However the CNS targets for leptin are not restricted to the hypothalamus as a high density of leptin receptors are also expressed in ...
Harvey, Jenni, Mcgregor, Gemma
core +3 more sources