Results 111 to 120 of about 91,965 (229)

El trabajo interdisciplinar en la enfermedad de Huntington [PDF]

, 2014
Se argumenta la importancia del trabajo en equipo en la atención de las personas afectadas por la Enfermedad de Huntington y de sus familias, y se describen las principales funciones de los distintos profesionales que han de cubrir sus necesidades en ...
Fernández Hawrylak, María, Fernández Sastre, Beatriz, Grau Rubio, Claudia, Hernández Lozano, David   +3 more
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Volume Estimation of the Thalamus Using Freesurfer and Stereology: Consistency between Methods [PDF]

, 2012
Freely available automated MR image analysis techniques are being increasingly used to investigate neuroanatomical abnormalities in patients with neurological disorders.
Christoph Kellinghaus, E. Bernd Ringelstein, Harald Kugel, Jan S. Gerdes, Katja Deppe, Michael Deppe, Siawoosh Mohammadi, Simon S. Keller, Stefan Evers, Wolfram Schwindt   +9 more
core   +1 more source

Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases. [PDF]

, 2014
Using expression profiles from postmortem prefrontal cortex samples of 624 dementia patients and non-demented controls, we investigated global disruptions in the co-regulation of genes in two neurodegenerative diseases, late-onset Alzheimer's disease (AD)
Casaccia, Patrizia, Emilsson, Valur, Fan, Guoping, Huynh, Jimmy L, Johnson, Andrew D, Lamb, John R, McElwee, Joshua, Melquist, Stacey, Molony, Cliona, Narayanan, Manikandan, Schadt, Eric E, Stone, David J, Suver, Christine, Wang, Kai, Xie, Tao, Yang, Xia, Yoo, Seungyeul, Zhang, Bin, Zhang, Chunsheng, Zhu, Jun   +19 more
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Enfermedad de Huntington: estado del arte [PDF]

, 2014
La enfermedad de Huntington es un desorden monogenético autosómico dominante, que genera un trastorno neurodegenerativo caracterizado por la pérdida de neuronas en diferentes partes del cerebro.
Rodas Sepúlveda, Carlos Daniel, Sierra García, Natalia   +1 more
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T1DBase: integration and presentation of complex data for type 1 diabetes research [PDF]

, 2007
T1DBase (http://T1DBase.org) [Smink et al. (2005) Nucleic Acids Res., 33, D544-D549; Burren et al. (2004) Hum. Genomics, 1, 98-109] is a public website and database that supports the type 1 diabetes (T1D) research community.
Hulbert, Erin M, Smink, Luc J, Adlem, Ellen C, Allen, James E, Burdick, David B, Burren, Oliver S, Cassen, Victor M, Cavnor, Christopher C, Dolman, Geoffrey E, Flamez, Daisy, Friery, Karen F, Healy, Barry C, Killcoyne, Sarah A, Kutlu, Burak, Schuilenburg, Helen, Walker, Neil M, Mychaleckyj, Josyf, Eizirik, Décio L, Wicker, Linda S, Todd, John A, Goodman, Nathan   +20 more
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Adeno-Associated Viral Vector Serotype DJ-Mediated Overexpression of N171-82Q-Mutant Huntingtin in the Striatum of Juvenile Mice Is a New Model for Huntington’s Disease

Frontiers in Cellular Neuroscience, 2018
Huntington’s disease (HD) is an autosomal-dominant inherited neurodegenerative disorder characterized by motor, psychiatric and cognitive symptoms. HD is caused by an expansion of CAG repeats in the huntingtin (HTT) gene in various areas of the brain ...
Minhee Jang, Seung Eun Lee, Ik-Hyun Cho, Ik-Hyun Cho   +3 more
doaj   +1 more source

Altered Balance of Activity in the Striatal Direct and Indirect Pathways in Mouse Models of Huntington's Disease [PDF]

, 2011
Imbalance in the activity of striatal direct and indirect pathway neurons contributes to motor disturbances in several neurodegenerative diseases. In Huntington’s disease (HD), indirect pathway [dopamine (DA) D2 receptor-expressing)] medium-sized spiny ...
Véronique M. André, Yvette E. Fisher, Michael S. Levine   +2 more
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Search for SCA2 blood RNA biomarkers highlights Ataxin-2 as strong modifier of the mitochondrial factor PINK1 levels

Neurobiology of Disease, 2016
Ataxin-2 (ATXN2) polyglutamine domain expansions of large size result in an autosomal dominantly inherited multi-system-atrophy of the nervous system named spinocerebellar ataxia type 2 (SCA2), while expansions of intermediate size act as polygenic risk ...
Nesli Ece Sen, Jessica Drost, Suzana Gispert, Sylvia Torres-Odio, Ewa Damrath, Michael Klinkenberg, Hamid Hamzeiy, Gülden Akdal, Halil Güllüoğlu, A. Nazlı Başak, Georg Auburger   +10 more
doaj   +1 more source

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage [PDF]

, 2017
To test the hypotheses that mutant huntingtin protein length and wild-type huntingtin dosage have important effects on disease-related transcriptional dysfunction, we compared the changes in mRNA in seven genetic mouse models of Huntington's disease (HD)
Albin, Roger, Augood, Sarah J., Bates, Gillian P., Becanovic, Kristina, Cha, Jang-Ho J., Delorenzi, Mauro, Dunnett, Stephen B., Faull, Richard L.M., Ferrante, Robert J., Goldstein, Darlene R., Hannan, Anthony J., Hayden, Michael R., Hodges, Angela, Jones, Lesley, Kooperberg, Charles, Kuhn, Alexandre, Leavitt, Blair R., Luthi-Carter, Ruth, Olson, James M., Pouladi, Mahmoud A., Sathasivam, Kirupa, Sengstag, Thierry, Shelbourne, Peggy, Strand, Andrew D.   +23 more
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Juvenile onset Huntington's disease in an Omani child with asymptomatic, at risk parents. [PDF]

, 1997
Euan M. Scrimgeour, Roshan Koul, Prem Chand, John Tharakan, C A Frew   +4 more
openalex   +1 more source