Results 81 to 90 of about 80,831 (209)

Role of mitochondria in Parkinson disease [PDF]

, 1999
The cause of the selective degeneration of nigrostriatal neurons in Parkinson disease (PD) has remained largely unknown. Exceptions include rare missense mutations in the alpha-synuclein gene on chromosome 4, a potentially pathogenic mutation affecting ...
Graeber, M. B., Hofhaus, G., Kösel, S., Maassen, A., Vieregge, P.   +4 more
core   +1 more source

Microglial Depletion, a New Tool in Neuroinflammatory Disorders: Comparison of Pharmacological Inhibitors of the CSF‐1R

Glia, Volume 73, Issue 4, Page 686-700, April 2025.
Main Points Microglial survival relies on CSF‐1R signaling, which can be inhibited pharmacologically. CSF‐1R inhibitors deplete microglia and reduce neuroinflammation in neurodegenerative models. Effects on other CNS during neurodevelopment are unclear.
David Guenoun, Nathan Blaise, Alexandre Sellam, Julie Roupret‐Serzec, Alice Jacquens, Juliette Van Steenwinckel, Pierre Gressens, Cindy Bokobza   +7 more
wiley   +1 more source

Prey Remains From Stomachs of Killer Whales (Orcinus orca) Stranded in Alaska, 2005–2021

Marine Mammal Science, EarlyView.
Anna L. Bryan, Lori Quakenbush, Sadie Wright, Kelly Robertson, Emma R. Horton, Kim M. Parsons, Aren Gunderson   +6 more
wiley   +1 more source

STAT3 Signaling Pathway in Health and Disease

MedComm, Volume 6, Issue 4, April 2025.
An image depicting the role of STAT3 in various human diseases ABSTRACT Signal transducer and activator of transcription 3 (STAT3) is a critical transcription factor involved in multiple physiological and pathological processes. While STAT3 plays an essential role in homeostasis, its persistent activation has been implicated in the pathogenesis of ...
Md Abdus Samad, Iftikhar Ahmad, Aakifah Hasan, Mohammad Hassan Alhashmi, Arusha Ayub, Fahad A. Al‐Abbasi, Ajoy Kumer, Shams Tabrez   +7 more
wiley   +1 more source

The latent stem cell population is retained in the hippocampus of transgenic Huntington's disease mice but not wild-type mice [PDF]

, 2010
The demonstration of the brain's ability to initiate repair in response to disease or injury has sparked considerable interest in therapeutic strategies to stimulate adult neurogenesis.
A van Dellen, Anthony J. Hannan, AS Tattersfield, CMC Batista, DJ Jhaveri, Eirinn W. Mackay, Geoff W. Turnbull, HE Grote, HG Kuhn, Jialin Zheng, L Mangiarini, M Turmaine, MA Curtis, MA Curtis, ND Bull, NK Mazarakis, Perry F. Bartlett, RJ Felling, SE Lazic, SE Lazic, T Seki, Tara L. Walker, TL Spires, TL Walker, TL Walker, TY Pang, W Phillips   +26 more
core   +5 more sources

Targeting Frequent Efferocytosis in Tumor Microenvironment is a New Direction for Cancer Treatment

Small Science, Volume 5, Issue 4, April 2025.
Phagocytosis of “apoptotic tumor cells”, known as efferocytosis, accelerates the formation of an immunosuppressive microenvironment, leading to the detriment of tumor therapy. Blocking this process represents one of the novel approaches for treating tumors.
Gangxing Zhu, Xinliang Wan, Wanyin Wu, Luyu Jia, Xiaoyan Yu, Handan Mo, Xi Wang, Qichun Zhou, Qing Tang, Sumei Wang   +9 more
wiley   +1 more source

Patterns of Neural Activity and Clinical Outcomes in a Juvenile Huntington's Disease Patient Undergoing Deep Brain Stimulation of the Subthalamic Nucleus

Deep Brain Stimulation, 2023
A. Kaymak, M. Vissani, M. Lenge, F. Melani, Edoardo Fino, P. Cappelletto, G. Tuccinardi, M. Cavallo, Flavio Giordano, A. Mazzoni   +9 more
semanticscholar   +1 more source

Biallelic mutations in huntington disease: A new case with just one affected parent, review of the literature and terminology [PDF]

, 2015
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111167/1/ajmga37009 ...
Alonso, American College of Medical Genetics/American Society of Human Genetics Huntington Disease Genetic Testing Working Group, Aziz, Aziz, Brocklebank, Costa, Cottrell, Ding, Djousse, Durr, Elli, Engel, Evans, Fisher, Goldberg, Goldberg, Huntington's Disease Collaborative Research Group, Kotzot, Kremer, Kremer, Kuchinka, Laccone, Laccone, Lee, Lindor, Maat-Kievit, Maat-Kievit, Middleton, Myers, Potter, Raskin, Sanchez, Sanchez, Scionti, Semaka, Semaka, Semaka, Semaka, Semaka, Semeka, Sequeiros, Shi, Snell, Spena, Squitieri, Squitieri, Squitieri, Tassiker, Wexler, Wexler, Yamazawa, Yao, Young   +52 more
core   +1 more source

The CAG repeat at the Huntington disease gene in the Portuguese population : insights into its dynamics and to the origin of the mutation [PDF]

, 2006
Huntington disease (HD) is caused by an expansion of a CAG repeat. This repeat is a dynamic mutation that tends to undergo intergenerational instability.
Alda Sousa, AM Andrés, B Kremer, DC Rubinsztein, EW Almqvist, F Squitieri, HL Paulson, I Vuillaume, JB Martin, Jorge Sequeiros, Laura Guimarães, M Cossée, M Duyao, M Raymond, Maria do Carmo Costa, MC Costa, N Masuda, Patrícia Maciel, Paula Magalhães, S Pramanik, SE Andrew, SE Andrew, SW Guo, The, The, WS Watkins, YP Goldberg, YP Goldberg   +27 more
core   +1 more source

El trabajo interdisciplinar en la enfermedad de Huntington [PDF]

, 2014
Se argumenta la importancia del trabajo en equipo en la atención de las personas afectadas por la Enfermedad de Huntington y de sus familias, y se describen las principales funciones de los distintos profesionales que han de cubrir sus necesidades en ...
Fernández Hawrylak, María, Fernández Sastre, Beatriz, Grau Rubio, Claudia, Hernández Lozano, David   +3 more
core