Results 81 to 90 of about 83,768 (184)

Ginsenoside Rg1 as a Multifunctional Therapeutic Agent: Pharmacological Properties, Molecular Mechanisms and Clinical Perspectives in Complementary Medicine

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Ginsenoside Rg1 (Rg1) from Panax ginseng shows multifunctional health effects. Although oral bioavailability is low and blood–brain barrier (BBB) penetration is limited, delivery systems such as liposomes and nanoparticles may improve exposure. Rg1 reduces inflammation/oxidative stress by inhibiting nuclear factor‐κB (NF‐κB) signaling and reactive ...
Hernán Cortés, Enrique Lima, Lorena Duarte‐Peña, Sheila I. Peña‐Corona, Zainab M. Almarhoon, Rajesh Kaverikana, Shivaprasad Shetty Mangalpady, Vinayaka Babu Shet, Nikshitha Manjeshwar, Javad Sharifi‐Rad, Jen‐Tsung Chen, Gerardo Leyva‐Gómez, William N. Setzer, Daniela Calina   +13 more
wiley   +1 more source

Childhood-onset (Juvenile) Huntington's disease: A rare case report

Journal of Pediatric Neurosciences, 2015
Huntington′s disease (HD) is a rare dominantly inherited neurodegenerative disorder characterized clinically by a combination of abnormal involuntary (choreic) movements, neuropsychiatric manifestations, and dementia.
K. Patra, M. Shirolkar
semanticscholar   +1 more source

A Scoping Review of the Lived Experiences of Individuals With Huntington's Disease, Their Informal Caregivers and Offspring

Journal of Advanced Nursing, Volume 82, Issue 2, Page 1105-1123, February 2026.
ABSTRACT Background Huntington's disease has a disruptive effect on entire families. While previous reviews have examined lived experiences of individuals with Huntington's Disease, their informal caregivers, or their offspring, none have provided a comprehensive overview that integrates these three perspectives. Design A scoping review. Aims Providing
Cathelijn Van Baar, Kristel Kalkers, Sascha Bolt, Raymund Roos, Robbert Gobbens   +4 more
wiley   +1 more source

The CAG repeat at the Huntington disease gene in the Portuguese population : insights into its dynamics and to the origin of the mutation [PDF]

, 2006
Huntington disease (HD) is caused by an expansion of a CAG repeat. This repeat is a dynamic mutation that tends to undergo intergenerational instability.
Alda Sousa, AM Andrés, B Kremer, DC Rubinsztein, EW Almqvist, F Squitieri, HL Paulson, I Vuillaume, JB Martin, Jorge Sequeiros, Laura Guimarães, M Cossée, M Duyao, M Raymond, Maria do Carmo Costa, MC Costa, N Masuda, Patrícia Maciel, Paula Magalhães, S Pramanik, SE Andrew, SE Andrew, SW Guo, The, The, WS Watkins, YP Goldberg, YP Goldberg   +27 more
core   +1 more source

Modulators of Diacylglycerol Kinase Activity: A Review of Advances and Challenges

Medicinal Research Reviews, Volume 46, Issue 1, Page 149-175, January 2026.
ABSTRACT Catalyzing the conversion of diacylglycerol (DAG) in phosphatidic acid (PA), diacylglycerol kinases (DGKs) play a pivotal role in all the physiological processes modulated by these two bioactive lipids, such as lipid metabolism and immune regulation.
Luisa Racca, Gianluca Baldanzi, Alberto Massarotti   +2 more
wiley   +1 more source

Juvenile‐onset Huntington's disease – Spectrum and evolution of presenting movement disorders

Annals of Clinical and Translational Neurology
Juvenile‐onset Huntington's disease (HD) is a rare subset of HD with symptom‐onset before the age of 18. In contrast to the adult population, children present early‐on with behavioral, psychiatric, and cognitive symptoms, in addition to a diverse ...
Kathryn Yang, Vicente Quiroz, Amy Tam, Rasha Srouji, Ximena Villanueva, Claudia Amarales, Darius Ebrahimi‐Fakhari   +6 more
doaj   +1 more source

Juvenile Huntington's disease confirmed by genetic examination in twins Doença de Huntington juvenil confirmada por exame genético em gêmeas

Arquivos de Neuro-Psiquiatria, 1999
Early-onset Huntington's disease (HD) occurs in approximately 10% of HD's cases. We report juvenile HD in phenotypically identical twins, evaluated by history, clinical and neurologic examination, mini-mental state examination, blood laboratory exams ...
GILBERTO LEVY, MARIA EDUARDA NOBRE, VINICIUS T. CIMINI, SALMO RASKIN, ELIASZ ENGELHARDT   +4 more
doaj   +1 more source

Neutral theory: applicability and neutrality of clinical study endpoints where a disease-specific instrument is available

BMC Medical Research Methodology, 2023
Background There is a pressing need to improve the accuracy of rare disease clinical study endpoints. Neutral theory, first described here, can be used to assess the accuracy of endpoints and improve their selection in rare disease clinical studies ...
Ravi Jandhyala
doaj   +1 more source

El trabajo interdisciplinar en la enfermedad de Huntington [PDF]

, 2014
Se argumenta la importancia del trabajo en equipo en la atención de las personas afectadas por la Enfermedad de Huntington y de sus familias, y se describen las principales funciones de los distintos profesionales que han de cubrir sus necesidades en ...
Fernández Hawrylak, María, Fernández Sastre, Beatriz, Grau Rubio, Claudia, Hernández Lozano, David   +3 more
core  

Molecular diagnosis of Huntington disease in Portugal : implications for genetic counselling and clinical practice [PDF]

, 2003
Huntington disease (HD) is a eurodegenerative, autosomal dominant disorder of late-onset, caused by the expansion of a CAG repeat in the coding region of the gene. Ours is the reference laboratory for genetic testing in HD, in Portugal, since 1998; 90.1%
A Durr, Alda Sousa, B Kremer, Carolina Garrett, CM James, Cristina Januário, D Craufurd, D Falush, DGR Evans, EW Almqvist, Fernando Regateiro, Fátima Ferreirinha, Isabel Gaspar, J Sambrook, JB Martin, Jorge Sequeiros, José Vale, Laura Guimarães, Leal Loureiro, M Guida, M Losekoot, Maria do Carmo Costa, Marina Magalhães, MR Hayden, Patrícia Maciel, Paula Magalhães, PS Harper, PS Harper, RC Moore, RG Snell, RH Myers, S Siesling, SA Simpson, SE Andrew, SE Andrew, SE Andrew, SE Andrew, SE Holmes, YP Goldberg, YP Goldberg   +39 more
core   +1 more source