Long-term methotrexate efficacy in juvenile localized scleroderma [PDF]
Pediatric Rheumatology Online Journal, 2011 Methods We prospectively followed a cohort of patients with JLS who were enrolled in a double-blind, randomized controlled trial. Oral MTX was used at a dose of 15 mg/m once a week (max 20 mg) for at lest 24 months; prednisone (1 mg/Kg/day, max 50 mg), in a single morning dose for 3 months was added.
Giuliotto S +5 more
doaj +13 more sources
Juvenile localized scleroderma with autoimmune thyroid disorder
Indian Journal of Dermatology, 2010 Hiremath N +5 more
doaj +6 more sources
Efficacy and safety of methotrexate treatment of juvenile localized scleroderma [PDF]
Pediatric Rheumatology Online Journal, 2008 Our goal is to study the efficacy and safety of MTX in juvenile localized scleroderma (JLS). Retrospective study of 59 chlidren with JLS from 3 to 17 y (M = 10.3) treated with MTX was performed. Group 1 (n = 18) – received prednisone 0.5 mg\kg for 6 weeks, taped to 0.1 mg\kg for 12 months + MTX 10 mg\body sq. weekly for 13.7 mo.
Osminina MK +4 more
doaj +7 more sources
Juvenile localized scleroderma: A disease with significant morbidity [PDF]
Journal of the European Academy of Dermatology and Venereology, 2023 Localized scleroderma (Syn: Morphoea) is an autoimmune disorder manifesting as sclerosis, atrophy of skin, subcutaneous tissue and may extend into underlying muscle and bone. Although juvenile localized scleroderma is a rare disorder, 20– 30% of patients
Shital Poojary
semanticscholar +4 more sources
Reliability of using an ultrasound scoring measure for juvenile localized scleroderma (jLS) [PDF]
Pediatric Rheumatology Online Journal, 2012 Purpose Although ultrasound shows great potential for aiding assessment of LS disease activity, its use has been limited because both image acquisition and interpretation are operator dependent. To facilitate evaluating and to standardize interpretation of jLS ultrasound scans, we generated a scoring measure for evaluating echogenicity and vascularity ...
Li Suzanne C +13 more
doaj +7 more sources
Durometry as an outcome measure in juvenile localized scleroderma. [PDF]
Br J Dermatol, 2016 Poff S +4 more
europepmc +6 more sources
Systematic Review of
Arthritis care & research, 2023 The prevalence and types of psychosocial complications of juvenile localized scleroderma (JLS), also known as morphea, an inflammatory and sclerosing disease involving the skin, fascia, muscle, and bone, are poorly understood.
Luis Fernando Sánchez‐Espino +5 more
openalex +2 more sources
Predictors of Longitudinal Quality of Life in Juvenile Localized Scleroderma. [PDF]
Arthritis Care Res (Hoboken), 2017 ObjectiveLocalized scleroderma can negatively affect children's quality of life (QoL), but predictors of impact have not been well described. We sought to identify predictors of QoL impact in juvenile localized scleroderma patients.MethodsWe analyzed longitudinal data from a single‐center cohort of juvenile localized scleroderma patients, using ...
Ardalan K, Zigler CK, Torok KS.
europepmc +7 more sources
A Scoping Review of the Efficacy and Safety of Methotrexate Compared to Mycophenolate Mofetil in the Treatment of Juvenile Localized Scleroderma in Children and Young Adults [PDF]
SN Comprehensive Clinical Medicine, 2023 Juvenile localised scleroderma (JLS) is a condition that results in inflammation and fibrosis of the skin in children and young people. Systemic treatment with immunomodulation is most commonly with Methotrexate (MTX) or Mycophenolate Mofetil (MMF ...
Shabnam Singhal +4 more
openalex +2 more sources
Development of consensus treatment plans for juvenile localized scleroderma: a roadmap toward comparative effectiveness studies in juvenile localized scleroderma. [PDF]
Arthritis Care Res (Hoboken), 2012 AbstractObjectiveJuvenile localized scleroderma (LS) is a chronic inflammatory skin disorder associated with substantial morbidity and disability. Although a wide range of therapeutic strategies has been reported in the literature, a lack of agreement on treatment specifics and accepted methods for clinical assessment has made it difficult to compare ...
Li SC +24 more
europepmc +6 more sources