Results 91 to 100 of about 15,299 (212)

Single‐Cell RNA Sequencing Informs Precision Targeting of Monogenic Lupus Associated With IKZF1 Haploinsufficiency

Arthritis &Rheumatology, Volume 78, Issue 6, Page 1231-1244, June 2026.
Objective This study aimed to investigate the mechanisms of immune dysregulation in a pediatric patient with monogenic lupus driven by IKZF1 haploinsufficiency. Methods Peripheral immune cells from a patient with IKZF1 haploinsufficiency, patients with lupus with no currently known genetic mutations, and healthy controls were analyzed using single‐cell
Qi Zheng, Yejun Tan, Zhaoling Wang, Yanjie Qian, Qian Ma, Danping Shen, Meiping Lu   +6 more
wiley   +1 more source

Comparison of bone mass and quality determinants in adolescents and young adults with juvenile systemic lupus erythematosus (JSLE) and juvenile idiopathic arthritis (JIA) [PDF]

, 2014
Comparison of bone mass and quality determinants in adolescents and young adults with juvenile systemic lupus erythematosus (JSLE) and juvenile idiopathic arthritis ...
Matucci Cerinic, Marco, De Martino, Maurizio, Stagi, Stefano, Cavalli, Loredana, Brandi, Maria Luisa, Bertini, Federico, Falcini, Fernanda   +6 more
core   +1 more source

Nonclinical Considerations for Support of Pregnancy and Lactation in Clinical Trials

Birth Defects Research, Volume 118, Issue 6, June 2026.
ABSTRACT Background Pregnant and breastfeeding individuals remain underrepresented in clinical drug development, leaving health care providers and patients with limited data to inform treatment decisions. Current practice relies heavily on nonclinical developmental and reproductive toxicity (DART) studies in animals, while clinical trials typically ...
Dinesh Stanislaus, Christopher J. Bowman, Kimberly C. Brannen, Sarah N. Campion, Laura M. Carlson, Stephan Chalon, Anthony M. DeLise, Claudia Demarta‐Gatsi, Brian P. Enright, Wendy Halpern, Shermaine Mitchell‐Ryan, Vicki Sutherland, Karen Thacker, Kary Thompson, Belen Tornesi, Steven Van Cruchten, Ronald L. Wange, Tacey White, Connie L. Chen   +18 more
wiley   +1 more source

Acquired angioedema in juvenile systemic lupus erythematosus: case-based review

, 2018
An acquired form of angioedema that is clinically similar but scarcer than the hereditary form may be caused, even more rarely, by the presence of an underlying autoimmune disease.
Selçuk Yüksel, Yüksel, Selçuk, Gülçin Otar Yener, Zahide Ekici Tekin, Yener, Gülçin Otar, Tekin, Zahide Ekici   +5 more
core   +1 more source

The Effects of Jungian Sandplay Therapy on the Psychological Health of Children and Adolescents: A Systematic Review of Quantitative Studies

Counselling and Psychotherapy Research, Volume 26, Issue 2, June 2026.
ABSTRACT Introduction Sandplay therapy is a globally utilised depth‐oriented psychotherapy method that has expanded substantially over the past 15 years, reaching beyond Western contexts into Asia and Latin America. Grounded in a non‐verbal and non‐directive approach, sandplay is particularly valuable in therapeutic work with children, as well as ...
Juliette Ttofa, B. Les Lancaster, Peter Blundell, Olivia Pike, Marie Claire Van Hout, Sergio A. Silverio   +5 more
wiley   +1 more source

CLINICAL SIGNIFICANCE OF ANTIPHOSPHOLIPID ANTIBODIES AND GENE MUTATIONS IN HEMOSTASIS OF CHILDREN WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND JUVENILE DERMATOMYOSITIS

Педиатрическая фармакология, 2006
Thrombophilia in children with diffuse connective tissue disorders as systemic lupus erythematosus (SLE) and juvenile dermatomyositis (JDM) could arise from various causes including peripherial blood circulation of antiphospholipid antibodies (APH) and ...
O.A. Solntseva
doaj   +2 more sources

Heart rate variability in juvenile systemic lupus erythematosus patients

The Turkish Journal of Pediatrics, 2019
Although neurological involvement has been well recognized in patients with systemic lupus erythematosus (SLE), autonomic nervous system (ANS) involvement has rarely been studied, and has shown conflicting results.
Özge Başaran, İbrahim İlker Çetin, Fatma Aydın, Nermin Uncu, Nilgün Çakar, Filiz Ekici, Banu Çelikel Acar   +6 more
doaj   +1 more source

Mesenteric vasculitis in a juvenile systemic lupus erythematosus patient

Revista Brasileira de Reumatologia (English Edition), 2013
Lupus mesenteric vasculitis (LMV) is a rare cause of acute abdominal pain. Few cases of LMV have been reported in adults, children and adolescents. However, to our knowledge, the prevalence of that severe vasculitis in a pediatric population with lupus is yet to be studied.
Albuquerque-Netto, Adão F., Cavalcante, Erica G., Sallum, Adriana M.E., Aikawa, Nádia E., Tannuri, Uenis, Almeida da Silva, Clovis Artur   +5 more
openaire   +2 more sources

Tacrolimus as Single‐Agent Immunotherapy for Adult‐Onset Myasthenia Gravis: Remission, Relapse, and Safety

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Tacrolimus monotherapy yields high remission in adult‐onset MG, especially in new‐onset or younger patients. Relapse is linked to low tacrolimus concentration and rapid tapering. Hyperglycemia was the most common ADR. Long‐term use may increase cancer risk.
Zhangyan Geng, Yuting Jiang, Nairong Xie, Wenjia Zhu, Hai Chen, Yaye Wang, Haoran Liu, Qinyao Liu, Congwen Lv, Yu Qian, Yan Lu, Li Di, Min Wang, Min Xu, Xinmei Wen, Bingchuan Xie, Yuwei Da   +16 more
wiley   +1 more source

Systemic lupus erythematosus with Jaccoud's arthropathy mimicking juvenile rheumatoid arthritis.

, 1987
We describe a girl who presented at age 5 with objective signs of arthritis and was initially diagnosed as having juvenile rheumatoid arthritis. Over the following years, she developed slowly progressive joint deformities indicative of Jaccoud's ...
S. Viola, R. G. Burgio, MARTINI, ALBERTO, RAVELLI, ANGELO   +3 more
core