Results 101 to 110 of about 73,773 (231)

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux   +26 more
wiley   +1 more source

Køn, seksualitet, intersektionalitet

open access: yes, 2019
Kapitlet introducerer til forskning og teoriudvikling om køn og seksualitet med særligt fokus på teoretiske nybrud inden for de seneste 30-40 år, herunder introduktion til køn som social konstruktion/doing gender-perspektivet samt kønsoverskridende ...
Faber, Stine Thidemann; id_orcid
core  

Rozwój turystyki konnej w województwie podlaskim w świetle badań

open access: yesWieś i Rolnictwo, 2011
W opracowaniu dokonano analizy rozwoju turystyki konnej w województwie podlaskim. Województwo to szczególnie nadaje się do organizacji tego rodzaju turystyki i przeprowadzania badań z uwagi na liczne występowanie tej grupy zwierząt.
Mikołaj Jalinik
doaj   +1 more source

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

open access: yesCell, 2012
SUMMARY Brown adipose tissue (BAT) can disperse stored energy as heat. Promoting BAT-like features in white adipose (WAT) is an attractive, if elusive therapeutic approach to staunch the current obesity epidemic.
L. Qiang   +10 more
semanticscholar   +1 more source

Splicing Factor Mutations in Clonal Hematopoiesis and Progression to Myeloid Neoplasms

open access: yesCancer Science, EarlyView.
Splicing factor (SF)‐mutant CH is characterized by relatively late emergence and accelerated clonal expansion in older individuals. This review summarizes its clonal dynamics, disease‐associated consequences of SF mutations in myeloid neoplasms, and candidate mechanisms that may contribute to age‐dependent selection.
Yang Lyu, Yutong Zhang, Ayana Kon
wiley   +1 more source

Køn i pædagogisk praksis

open access: yes, 2014
Med den nye bekendtgørelse for pædagoguddannelsen skærpes fokus på de studerendes viden om køn. Dette kapitel giver en indføring i en række teoretiske perspektiver på køn og introducerer til forskningen på området.
Valente, Ana Lisa   +1 more
core  

Otonom Diyabetik Nöropati ile Glisemik Kontrol Arasındaki İlişki

open access: yesAnkara Medical Journal, 2017
Amaç: Tip 2 diabetes mellituslu (DM) hastalarda gastrointestinal ve kardiyovasküler diyabetik otonomik nöropatinin değerlendirilmesi amaçlanmaktadır. Materyal ve Metot: DM hastalarından oluşan çalışma grubu Mart-Eylül 2012 tarihleri arasında incelendi ...
Gülşah Şahin   +5 more
doaj   +1 more source

Tumor suppression in the absence of p53-mediated cell cycle arrest, apoptosis, and senescence

open access: yesCell, 2012
Summary Cell-cycle arrest, apoptosis, and senescence are widely accepted as major mechanisms by which p53 inhibits tumor formation. Nevertheless, it remains unclear whether they are rate-limiting steps in tumor suppression.
Tongyuan Li   +7 more
semanticscholar   +1 more source

Unraveling the active site cover of coproheme decarboxylase from Listeria monocytogenes

open access: yesThe FEBS Journal, EarlyView.
During heme biosynthesis in Gram‐positive bacteria, coproheme decarboxylase (ChdC) catalyzes the conversion of four‐propionate substrate coproheme to the two propionate product heme b. Its active site is universally covered by a flexible linking loop. This study identifies an important histidine residue, which stabilizes the loop in a ChdC homolog.
Nikolaus Falb   +4 more
wiley   +1 more source

Køn i Seksualundervisningen - en diskursanalyse af køn, krop og seksualitet

open access: yes, 2008
Resumé af projektrapport Køn i Seksualundervisningen – en diskursanalyse af køn, krop og seksualitet Seksualundervisning har siden 1970 været et obligatorisk fag i den danske folkeskole.
Lundfos Thuesen, Sille   +1 more
core  

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