Results 81 to 90 of about 28,197 (148)

Do Brain Extracellular Fluid Concentrations Predict PET‐Inferred Receptor Occupancy in Human CNS? A Mechanistic Model‐Based Analysis of Dopamine D2 Receptor Ligands

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1389-1401, November 2026.
A mechanistic CNS PBPK model framework was applied to eight antipsychotic D2 receptor ligands, comparing brain extracellular fluid (brainECF) and brain cell membrane (brainM) as biophase for predicting human receptor occupancy compared against PET neuroimaging data. BrainM concentrations showed improved agreement with PET‐derived receptor occupancy for
Divakar Budda, J.G. Coen van Hasselt, Elizabeth C.M. de Lange   +2 more
wiley   +1 more source

Distribution of Arboreal Acarofauna in Two Species of Tropical Trees

Biotropica, Volume 58, Issue 6, November 2026.
Mite assemblages on tropical trees were structured primarily by vertical microhabitat rather than tree species, forming three distinct clusters from the forest floor to the canopy. Mesostigmata and Prostigmata were more abundant on Haldina cordifolia. Combining substrate washing and Tullgren–Berlese extraction captured complementary species assemblages
Maria A. Minor, Vladimir M. Salavatulin, Sergey G. Ermilov, Alexander A. Khaustov, Olga L. Makarova, Vladimir A. Khaustov, Alexey A. Kudrin, Duc Nguyen Trung   +7 more
wiley   +1 more source

Chemical Strategies for Multistimuli Responsive Dynamic Covalent Materials in Regenerative Medicine

Advanced Healthcare Materials, Volume 15, Issue 38, 16 October 2026.
Multistimuli responsive dynamic covalent materials integrate reversible chemistry with the complex chemical, mechanical, and biochemical cues of regenerative environments. This review highlights chemical strategies based on orthogonal dynamic bonds, multicomponent networks, and hierarchical architectures to regulate mechanics, degradation, and ...
Saurabh Joshi, Matthew B. Baker, Dominik Schauenburg   +2 more
wiley   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, Volume 13, Issue 57, 14 October 2026.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

At blive rektor i gymnasiet

Tidsskrift for Professionsstudier
To become the principal of a high school has traditionally been something highly honorable. An appointment filled with pride, significance, and, like so much else in high school, professionalism.
Lars Frode Frederiksen, Jakob Ditlev Bøje   +1 more
doaj  

Patterns of Proliferation in the Pacific Hagfish (Eptatretus stoutii) Retina Suggest an Ancient Origin for Adult Neurogenesis

Journal of Comparative Neurology, Volume 534, Issue 10, October 2026.
The hagfish, a jawless early‐branching vertebrate, has very rudimentary eyes that are diminutive and oddly devoid of melanin pigment. Yet, the degenerate hagfish eye grows throughout life and expresses canonical genes of vertebrate retinal development. ABSTRACT Comparative morphology has revealed fascinating structural and organizational differences in
Sarah N. Bradshaw, William T. Allison
wiley   +1 more source

Pharmacokinetics of Intravenous Melatonin in Preschool‐Aged Pediatric Surgical Patients

Pediatric Anesthesia, Volume 36, Issue 10, Page 1308-1315, October 2026.
ABSTRACT Background Melatonin may have several beneficial clinical effects in the perioperative setting. In children, it has been studied for preoperative anxiety, postoperative pain, and emergence delirium. Melatonin's pharmacokinetic profile is well‐known in adults, but data in young children are sparse.
Anne Louise de Barros Garioud, Arash Afshari, Lau Romlund Halgreen, Kristian Østergaard Nielsen, Lars Peter Kloster Andersen   +4 more
wiley   +1 more source

Best practices for cryo‐trapping time‐resolved crystallography with the Spitrobot crystal plunger

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Capturing meta‐stable conformations of enzymes and ligand complexes demands structural snapshots beyond static crystal structures. While time‐resolved serial crystallography at room temperature offers a time‐resolution down to the femto‐second domain, it requires large amounts of micro crystals, specialized beamlines, and considerable ...
Robert Bosman, Caitlin E. Hatton, Andreas Prester, Maria Spiliopoulou, Virginia Apostolopoulou, Friedjof Tellkamp, Pedram Mehrabi, Eike C. Schulz   +7 more
wiley   +1 more source

Strategy for modular assembly of tetravalent, multispecific antibodies

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Multispecific, multivalent antibodies (Abs) are a burgeoning class of drugs that dramatically expand the pharmacological repertoire beyond traditional therapeutic Abs. Here, we present a simple, modular approach to developing multispecific, multivalent Abs based on a Fab‐phage library with a single light chain.
Evan Mallette, Levi L. Blazer, Craig A. Hokanson, Chao Chen, Julia Garcia Perez, Alevtina Pavlenco, Lynda Ploder, Alexander U. Singer, Michael D. L. Suits, Sunil Bhakta, Jagath R. Junutula, Jarrett J. Adams, Sachdev S. Sidhu   +12 more
wiley   +1 more source

The lower γ region supports forward rotation in the latter half of the 80° substep of F1‐ATPase

Protein Science, Volume 35, Issue 10, October 2026.
Abstract F1‐ATPase achieves unidirectional rotation of its γ shaft through coordinated conformational cycling of the α3β3 ring, yet how shaft–ring interactions contribute to the directionality of rotation remains unclear. Here we analyzed an axle‐less TF1, in which the lower γ region is truncated, by combining single‐molecule rotation assays with cryo ...
Tomo Uchiyama, Hiroshi Ueno, Meghna Sobti, Emily J. Furlong, Simon H. J. Brown, Alastair G. Stewart, Hiroyuki Noji   +6 more
wiley   +1 more source