Results 41 to 50 of about 41,602 (189)

Post‐LECA Origin and Diversification of an Axonemal Outer Arm Dynein Motor

Cytoskeleton, EarlyView.
ABSTRACT Dyneins were present in the last eukaryotic common ancestor (LECA) and play key roles in eukaryotic biology. Axonemal dyneins form the inner and outer arms that power ciliary beating, and it has long been recognized that outer arms in some organisms contain two different heavy chain motors, whereas those from other species contain a third unit
Stephen M. King
wiley   +1 more source

Køn som infrastruktur

Kvinder, Køn & Forskning, 2011
Gender as infrastructure. Based on the theoretical conception of ‘infrastructure' the article explores how gender can be understood in the context of the Danish information infrastructure CPR, which registers all Danish citizens.
Beate Sløk-Andersen
doaj   +1 more source

Køn i cyberspace

Kvinder, Køn & Forskning, 1998
The article suggests that questions of sex/gender and advanced information technologies can be addressed through the concept it encircles prevaling discourses about sex/gender and technology and analyses the mertaphor of cyberspece within the context of ...
Randi Markussen
doaj   +1 more source

Construction of a clickable probe‐based protein chip platform for discovering covalent mIDH1 inhibitors from natural medicinal extracts

iMeta, EarlyView.
In this study, we develop a flexible Ccc‐Chip (protein microarray + bioorthogonal click chemistry) for high‐throughput screening of natural covalent active molecules from medicinal plant extracts, identifying flavokawain C from Piper methysticum Forst as a novel covalent mIDH1 inhibitor.
Zhao Cui, Jiameng Li, Caifeng Li, Mo Sun, Wei Liu, Xuxia Cao, Shiwen Deng, Junxian Cao, Hongjun Yang, Peng Chen   +9 more
wiley   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Gender Mainstreaming in Transport Policy in Sweden

Kvinder, Køn & Forskning, 2004
Hvorfor har integrationen af køn i svensk transportpolitik fulgt en konservativ kurs og ikke en mere progressiv vej? Det skyldes blandt andet en uafklaret forståelse af køn som analytisk kategori.
Merritt Polk
doaj   +1 more source

Rehabilitation and return to activity after platelet‐rich plasma injections in chronic tendinopathies: Consensus from international experts

PM&R, EarlyView.
Abstract Background The effectiveness of platelet‐rich plasma (PRP) injections in chronic tendinopathies remains debated. Although the product's characteristics play a role, the impact of postinjection recommendations remains poorly investigated. Objective To establish principles and guidelines for post‐PRP injection rehabilitation and return to ...
Vincent Gremeaux, Martin Lamontagne, Valérie Bélanger, Etienne Dalmais, Eric Noël, Alain Frey, Paul Ornetti, Fadoua Allali, Jimmy Gross, F. Michel, Hervé Bard, Jean‐François Kaux, the GRIIP (Groupe de Recherche International sur les Injections de Plaquettes; International Research Group on Platelet Injections)   +12 more
wiley   +1 more source

"Min mormor er ikke vild med fodbold"

Kvinder, Køn & Forskning, 2001
Køn hverken overskrides eller determineres i sport. Køn er allestedsnærværende i sportens rum, men tillægges mangfoldige betydninger både fysisk, psykisk, socialt og kulturelt.
Lone Friis Thing
doaj   +1 more source

Mit dem Puppenwagen in die normative Weiblichkeit. Lili Elbe und die journalistische Inszenierung von Transsexualität in Dänemark [PDF]

, 2010
When the Danish painter Einar Wegener underwent several operations in 1930 in order to subsequently live as Lili Elvenes, the case was of great interest for both the public and the media.
Sabine Meyer
core   +1 more source

A minimal physiologically‐based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti‐LAG‐3 monoclonal antibody

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 460-473, March 2025.
Abstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Robin Michelet, Klas Petersson, Marc C. Huisman, C. Willemien Menke‐van der Houven van Oordt, Iris H. C. Miedema, Andrea Thiele, Ghazal Montaseri, Alejandro Pérez‐Pitarch, David Busse   +8 more
wiley   +1 more source