Results 61 to 70 of about 3,360,153 (260)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Exploring sources of engineering teaching self-efficacy for pre-service elementary teachers

International Journal of STEM Education, 2021
Background The Next Generation Science Standards (2013) put a special emphasis on engineering for K-12 science education. However, a significant number of elementary teachers still feel unprepared to integrate engineering into their science programs.
Ezgi Yesilyurt, Hasan Deniz, Erdogan Kaya   +2 more
doaj   +1 more source

Perceptions and predictions of expertise in advanced musical learners [PDF]

, 2010
The aim of this article was to compare musicians' views on (a) the importance of musical skills and (b) the nature of expertise. Data were obtained from a specially devised web-based questionnaire completed by advanced musicians representing four musical
Creech, Andrea, De Bezenac, Christophe, de Bezenac, Christophe, Duffy, Celia, Haddon, Elizabeth, Himonides, Evangelos, Morton, Frances, Papageorgi, Ioulia, Potter, John, Welch, Graham, Whyton, Tony   +10 more
core   +3 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Do tablets cure the pedagogy headache? [PDF]

, 2016
Tablet devices have made a huge impact in schools and in 2015 they were predicted to outsell personal computers (Gartner, 2014). 70 per cent of UK schools are estimated to be using tablets (BBC, online) and across Europe, “laptops, tablets and net-books ...
Hopkins, Paul
core  

Accounting students' expectations and transition experiences of supervised work experience [PDF]

, 2010
Political and economic discourses position employability as a responsibility of higher education, which utilise mechanisms such as supervised work experience (SWE) to embed employability into the undergraduate curriculum. However, sparse investigation of
Brown M., Easterby-Smith M., Fromm E., Glaser B. J., Gubrium J. F., Harvey L., Hawkins P., Hussey J., Louise Gracia, Marton F., Mason G., Norman D. A., Patton M. Q., Reinharz S., Ryder K. G., Saljo D., Schaafsma H., Wallace R.   +17 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Inquiry-based learning, the nature of science, and computer technology: New possibilities in science education

Canadian Journal of Learning and Technology, 2005
The teaching of science in the K-12 classroom has been less than successful. Students typically do not develop science literacy and do not understand the role and relevance of science in society.
John P Kubieck
doaj   +1 more source

Integrating science and engineering practices: outcomes from a collaborative professional development

International Journal of STEM Education, 2020
Background The Next Generation Science Standards accentuate engineering design along with scientific inquiry, emphasizing the relationship between scientific investigations and engineering design in solving problems and devising new ideas and ...
Brenda R. Brand
doaj   +1 more source

The role of the associate dean in UK universities: distributed leadership in action? [PDF]

, 2017
This paper reports on findings from a Leadership Foundation for Higher Education funded project exploring the role of associate deans in UK universities.
Floyd, Alan, Preston, Diane
core   +2 more sources