Results 51 to 60 of about 3,378,209 (280)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Learning science and technology through cooperative education. [PDF]

, 2007
Cooperative education, a form of experiential or work‐integrated learning is common in tertiary educational institutions worldwide. However, in New Zealand few institutions provide work‐integrated learning programs in science or technology, and the ...
Coll, Richard K., Eames, Chris W.
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Using Interactive Language Development Tools to Enhance Cognitive and Literacy Skills in K-12 Education

J-SHMIC: Journal of English for Academic
The incorporation of interactive language technologies, such as ChatGPT, into K-12 education has sparked interest as a way to improve language acquisition and cognitive development. This qualitative study investigates the perspectives and experiences of
Kurniawan Arif Maspul
doaj   +1 more source

Understanding intrinsic challenges to STEM instructional practices for Chinese teachers based on their beliefs and knowledge base

International Journal of STEM Education, 2020
Background China has great student participation in STEM education. Chinese society has a progressive and positive attitude towards STEM as it is considered to provide more opportunities in life.
Yan Dong, Jing Wang, Yunying Yang, Premnadh M. Kurup   +3 more
doaj   +1 more source

Aesthetics of the beautiful: Ideologic tensions in contemporary assessment [PDF]

, 2011
Pedagogy is an uncertain art. Yet by its very nature, contemporary teaching and learning practice typically suggests that the expert teacher must come to know their student well enough to plan and predict for educational challenges that will expand and ...
White, Elizabeth Jayne
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Children in Nature: lived experiences, knowledge and belonging

Educação & Realidade, 2019
This study is about the lived experiences of children in nature and the repercussions in their biopsychosocial development. From a Spinozean perspective, it is understood that everything is constructed from nature, whereby humans are beings of nature and,
Léa Tiriba, Cristiana Cabicieri Profice
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Learning Materials Utilizing Sustainability Pedagogy in Grade 8 Ecology

SEAQIS Journal of Science Education
Science education in the Philippines is anchored on the United Nations (UN) goals on sustainability education, as provided in K to 12 Science Curriculum, which envisions learners to be environmentally literate, critical problem solvers, and responsible ...
Esmeth Espinola
doaj   +1 more source