Results 41 to 50 of about 8,415,875 (317)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Radar signatures of sea lions at K‐band and W‐band

IET Radar, Sonar & Navigation
The millimetre wave radar signatures of sea lions collected from three animals in the outdoor seal pool available at the Sea Mammal Research Unit in St Andrews in the Autumn of 2021 is reported.
Samiur Rahman, Aleksanteri B. Vattulainen, Duncan A. Robertson, Ryan Milne   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Detection of the bright band with a vertically pointing k-band radar

Meteorologische Zeitschrift, 2014
Quantitative precipitation estimation based on weather radar data suffers from a variety of errors. During stratiform events, a region of enhanced reflectivity, called the bright band, leads to large positive biases in the precipitation estimates when ...
Thomas Pfaff, Alexander Engelbrecht, Jochen Seidel   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A K band deep galaxy survey

The Astrophysical Journal, 1990
The results of a K-band deep-imaging survey, with a 5 sigma limit of K = 21.4 for galaxy detection, are reported. Number counts from K = 16.5 to K = 21.25 are given. Comparison with optical survey data on the field shows objects as red as (I-K) = 5 which most probably correspond to high-redshift (z of about 2) normal galaxies.
L. L. Cowie, J. P. Gardner, S. J. Lilly, I. McLean   +3 more
openaire   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Direct to indirect band gap transition in two-dimensional germanium carbide through Si substitution

Results in Physics, 2019
In this work, the structural, electronic and optical properties of Si substituted single-layer GeC are studied by performing density functional theory calculations. Single-layer GeC possesses a direct band gap of 2.11 eV at the K point.
Somayeh Behzad
doaj   +1 more source

K-band luminosity–density relation at fixed parameters or for different galaxy families

Open Physics, 2020
Using the apparent magnitude-limited Main galaxy sample of the Sloan Digital Sky Survey Data Release 10, we examine the K-band luminosity–density relation at fixed parameters or for different galaxy families.
Deng Xin-Fa, Wen Xiao-Qing, Xin Yong, Qi Xiao-Ping, Ding Ying-Ping   +4 more
doaj   +1 more source